Analysis of aortic wall stress and morphology in patients with type B aortic dissection
Risk assessment is critical in preventing aortic dissection (AD). This study aims to evaluate the wall stress (WS) distribution, especially at the locations of proximal tears in patient-specific type-B aortic dissection (TBAD) to explore the pathogenesis of dissection. In addition, the shape of the...
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doaj-7d9041b47c614821bfff03982fea1d842021-08-30T04:14:08ZengElsevierMedicine in Novel Technology and Devices2590-09352021-09-0111100081Analysis of aortic wall stress and morphology in patients with type B aortic dissectionHongrui Hu0Zhan Liu1Guoxin Chen2Ding Yuan3Tinghui Zheng4Department of Applied Mechanics, Sichuan University, Chengdu, 610065, ChinaDepartment of Applied Mechanics, Sichuan University, Chengdu, 610065, ChinaDepartment Vascular Surgery of West China Hospital, Sichuan University, Chengdu, 610041, ChinaDepartment Vascular Surgery of West China Hospital, Sichuan University, Chengdu, 610041, China; Corresponding author. Department Vascular Surgery of West China Hospital, Sichuan University, Chengdu, 610041, China.Department of Applied Mechanics, Sichuan University, Chengdu, 610065, China; Corresponding author. Department of Applied Mechanics, Sichuan University, No. 24 South Section 1, Chengdu, 610065, China.Risk assessment is critical in preventing aortic dissection (AD). This study aims to evaluate the wall stress (WS) distribution, especially at the locations of proximal tears in patient-specific type-B aortic dissection (TBAD) to explore the pathogenesis of dissection. In addition, the shape of the aortas were assessed and associated with TBAD risk. In this paper, 30 three-dimensional models were reconstructed based on patient-specific CT angiography images, and finite element analysis (FEA) was used to analyze the admission blood pressure. In addition, the anatomic variables including the head vessel angles, the aorta diameters, curvatures and torturosity ware measured. Tears occurred at either local high WS or low WS region, and these acute TBAD patients can be classified into three groups based on the location of initial intimal tears. In addition, the WS values at tear sites of each group showed significant difference (P<0.001). Moreover, the angles of the left subclavian and brachiocephalic arteries were statistical different among three groups. Increased wall stress or decreased wall strength both contribute to the pathogenesis of aortic dissections. In addition, abnormal head vessel angles may be monitored as an important risk factor for aortic dissection, and its specific features may further help to determine the potential tear location.http://www.sciencedirect.com/science/article/pii/S2590093521000254Aortic dissectionFinite element analysisTear localizationAortic morphology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hongrui Hu Zhan Liu Guoxin Chen Ding Yuan Tinghui Zheng |
spellingShingle |
Hongrui Hu Zhan Liu Guoxin Chen Ding Yuan Tinghui Zheng Analysis of aortic wall stress and morphology in patients with type B aortic dissection Medicine in Novel Technology and Devices Aortic dissection Finite element analysis Tear localization Aortic morphology |
author_facet |
Hongrui Hu Zhan Liu Guoxin Chen Ding Yuan Tinghui Zheng |
author_sort |
Hongrui Hu |
title |
Analysis of aortic wall stress and morphology in patients with type B aortic dissection |
title_short |
Analysis of aortic wall stress and morphology in patients with type B aortic dissection |
title_full |
Analysis of aortic wall stress and morphology in patients with type B aortic dissection |
title_fullStr |
Analysis of aortic wall stress and morphology in patients with type B aortic dissection |
title_full_unstemmed |
Analysis of aortic wall stress and morphology in patients with type B aortic dissection |
title_sort |
analysis of aortic wall stress and morphology in patients with type b aortic dissection |
publisher |
Elsevier |
series |
Medicine in Novel Technology and Devices |
issn |
2590-0935 |
publishDate |
2021-09-01 |
description |
Risk assessment is critical in preventing aortic dissection (AD). This study aims to evaluate the wall stress (WS) distribution, especially at the locations of proximal tears in patient-specific type-B aortic dissection (TBAD) to explore the pathogenesis of dissection. In addition, the shape of the aortas were assessed and associated with TBAD risk. In this paper, 30 three-dimensional models were reconstructed based on patient-specific CT angiography images, and finite element analysis (FEA) was used to analyze the admission blood pressure. In addition, the anatomic variables including the head vessel angles, the aorta diameters, curvatures and torturosity ware measured. Tears occurred at either local high WS or low WS region, and these acute TBAD patients can be classified into three groups based on the location of initial intimal tears. In addition, the WS values at tear sites of each group showed significant difference (P<0.001). Moreover, the angles of the left subclavian and brachiocephalic arteries were statistical different among three groups. Increased wall stress or decreased wall strength both contribute to the pathogenesis of aortic dissections. In addition, abnormal head vessel angles may be monitored as an important risk factor for aortic dissection, and its specific features may further help to determine the potential tear location. |
topic |
Aortic dissection Finite element analysis Tear localization Aortic morphology |
url |
http://www.sciencedirect.com/science/article/pii/S2590093521000254 |
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