Serum carnitine concentration is decreased in patients with Lyme borreliosis
Background: Lyme borreliosis (LB) is a serious infectious disease. Carnitine plays a crucial role in metabolism and inflammatory responses. Carnitine may be important in improving neuronal dysfunction and loss of neurons.Aim: To evaluate serum carnitine concentration in adult patients with various c...
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doaj-7da0345c150e4ad1a998608a8adba8de2020-11-24T22:59:14ZengIndex Copernicus International S.A.Postępy Higieny i Medycyny Doświadczalnej0032-54491732-26932016-03-017018018510.5604/01.3001.0009.679701.3001.0009.6797Serum carnitine concentration is decreased in patients with Lyme borreliosisAlina Kępka0Sławomir A. Pancewicz1Roman M. Janas2Renata Świerzbińska3Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children’s Memorial Health Institute, Warsaw, PolandDepartment of Infectious Diseases and Neuroinfections, Medical University of Białystok, Białystok, PolandDepartment of Biochemistry, Radioimmunology and Experimental Medicine, The Children’s Memorial Health Institute, Warsaw, PolandDepartment of Infectious Diseases and Neuroinfections, Medical University of Białystok, Białystok, PolandBackground: Lyme borreliosis (LB) is a serious infectious disease. Carnitine plays a crucial role in metabolism and inflammatory responses. Carnitine may be important in improving neuronal dysfunction and loss of neurons.Aim: To evaluate serum carnitine concentration in adult patients with various clinical types of LB.Material/Methods: Groups: 1) patients with erythema migrans (EM, n=16), 2) neuroborreliosis (NB, n=10), 3) post-Lyme disease (PLD, n=22) and healthy controls (HC, n=32). Total (TC) and free (FC) carnitine were determined with the spectrophotometric method.Results: TC levels (44.9±10.4, 28.0±8.4, 35.9±15.6 μmol/L) in the EM, NB and PLD patients were lower than in HC (54.0±11.4 μmol/L), p < 0.001. FC levels (32.7±7.7, 23.6±6.8, 26.3±11.2 μmol/L) in the EM, NB and PLD patients were lower than in HC (40.5±7.6 μmol/L), p < 0.001. AC levels (12.2±5.2, 4.4±2.6, 9.6±7.4 μmol/L) in the EM, NB and PLD patients were lower in the NB and PLD patients than in HC (13.5±8.40 μmol/L), p <0.001. AC/FC ratio was 0.31±0.14, 0.18±0.09, 0.39±0.33 in the EM, NB and PLD patients.Conclusions: LB patients exhibit a significant decrease of their serum carnitine concentrations. The largest changes were in the NB and PLD patients. To prevent late complications of the disease a possibility of early supplementation with carnitine should be considered. Further studies are required to explain the pathophysiological significance of our findings. http://phmd.pl/gicid/01.3001.0009.6797Lyme borreliosiserythema migransneuroborreliosispost-Lyme diseasecarnitine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alina Kępka Sławomir A. Pancewicz Roman M. Janas Renata Świerzbińska |
spellingShingle |
Alina Kępka Sławomir A. Pancewicz Roman M. Janas Renata Świerzbińska Serum carnitine concentration is decreased in patients with Lyme borreliosis Postępy Higieny i Medycyny Doświadczalnej Lyme borreliosis erythema migrans neuroborreliosis post-Lyme disease carnitine |
author_facet |
Alina Kępka Sławomir A. Pancewicz Roman M. Janas Renata Świerzbińska |
author_sort |
Alina Kępka |
title |
Serum carnitine concentration is decreased in patients with Lyme borreliosis |
title_short |
Serum carnitine concentration is decreased in patients with Lyme borreliosis |
title_full |
Serum carnitine concentration is decreased in patients with Lyme borreliosis |
title_fullStr |
Serum carnitine concentration is decreased in patients with Lyme borreliosis |
title_full_unstemmed |
Serum carnitine concentration is decreased in patients with Lyme borreliosis |
title_sort |
serum carnitine concentration is decreased in patients with lyme borreliosis |
publisher |
Index Copernicus International S.A. |
series |
Postępy Higieny i Medycyny Doświadczalnej |
issn |
0032-5449 1732-2693 |
publishDate |
2016-03-01 |
description |
Background: Lyme borreliosis (LB) is a serious infectious disease. Carnitine plays a crucial role in metabolism and inflammatory responses. Carnitine may be important in improving neuronal dysfunction and loss of neurons.Aim: To evaluate serum carnitine concentration in adult patients with various clinical types of LB.Material/Methods: Groups: 1) patients with erythema migrans (EM, n=16), 2) neuroborreliosis (NB, n=10), 3) post-Lyme disease (PLD, n=22) and healthy controls (HC, n=32). Total (TC) and free (FC) carnitine were determined with the spectrophotometric method.Results: TC levels (44.9±10.4, 28.0±8.4, 35.9±15.6 μmol/L) in the EM, NB and PLD patients were lower than in HC (54.0±11.4 μmol/L), p < 0.001. FC levels (32.7±7.7, 23.6±6.8, 26.3±11.2 μmol/L) in the EM, NB and PLD patients were lower than in HC (40.5±7.6 μmol/L), p < 0.001. AC levels (12.2±5.2, 4.4±2.6, 9.6±7.4 μmol/L) in the EM, NB and PLD patients were lower in the NB and PLD patients than in HC (13.5±8.40 μmol/L), p <0.001. AC/FC ratio was 0.31±0.14, 0.18±0.09, 0.39±0.33 in the EM, NB and PLD patients.Conclusions: LB patients exhibit a significant decrease of their serum carnitine concentrations. The largest changes were in the NB and PLD patients. To prevent late complications of the disease a possibility of early supplementation with carnitine should be considered. Further studies are required to explain the pathophysiological significance of our findings.
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topic |
Lyme borreliosis erythema migrans neuroborreliosis post-Lyme disease carnitine |
url |
http://phmd.pl/gicid/01.3001.0009.6797 |
work_keys_str_mv |
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