Pancreaticoduodenectomy versus limited resection for duodenal gastrointestinal stromal tumors: a systematic review and meta-analysis
Abstract Background By comparing the long-term prognostic outcomes after pancreaticoduodenectomy (PD) and limited resection (LR), this study aimed to investigate the optimal surgical modality for duodenal gastrointestinal stromal tumors (GISTs). Methods Two authors independently searched PubMed, Web...
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doaj-7da935669d3d4929b71f37571f6b51332020-11-25T03:01:11ZengBMCBMC Surgery1471-24822019-08-011911910.1186/s12893-019-0587-4Pancreaticoduodenectomy versus limited resection for duodenal gastrointestinal stromal tumors: a systematic review and meta-analysisZefeng Shen0Ping Chen1Nannan Du2Parishit A. Khadaroo3Danyi Mao4Lihu Gu5The Second Clinical Medical College, Zhejiang Chinese Medical UniversityDepartment of General Surgery, HwaMei Hospital, University of Chinese Academy of SciencesThe Second Clinical Medical College, Zhejiang Chinese Medical UniversityMonash University School of Public Health and Preventive MedicineBasic Medical College, Zhejiang Chinese Medical UniversityDepartment of General Surgery, HwaMei Hospital, University of Chinese Academy of SciencesAbstract Background By comparing the long-term prognostic outcomes after pancreaticoduodenectomy (PD) and limited resection (LR), this study aimed to investigate the optimal surgical modality for duodenal gastrointestinal stromal tumors (GISTs). Methods Two authors independently searched PubMed, Web of Science, Embase, and the Cochrane Library for published articles comparing the long-term prognostic and clinicopathological factors of duodenal GIST patients undergoing PD versus LR. Relevant information was extracted and analyzed. Results After screening, 10 items comprising 623 cases were eventually included. This meta-analysis explicitly indicated that PD treatment was associated with worse long-term prognosis (hazard ratio = 1.93; 95% confidence interval [CI], 1.39–2.69; p < 0.001; I2 = 0) and more complications (odds ratio [OR] = 2.90; 95% CI, 1.90–4.42; p < 0.001; I2 = 10%) than LR treatment. Nevertheless, for duodenal GISTs, PD was related to the following clinicopathological features: invasion of the second part of the duodenum (OR = 3.39; 95% CI, 1.69–6.79; p < 0.001; I2 = 50%), high-degree tumor mitosis (> 5/50 high-power fields; OR = 2.24; 95% CI, 1.42–3.52; p < 0.001; I2 = 0), and high-risk classification (OR = 3.17; 95% CI; 2.13–4.71; p < 0.001; I2 = 0). Conclusions Since PD is associated with worse long-term prognosis and more complications, its safety and efficacy should be ascertained. Our findings recommend the use of LR to obtain negative incision margins when conditions permit it.http://link.springer.com/article/10.1186/s12893-019-0587-4Duodenal gastrointestinal stromal tumorsPancreaticoduodenectomyLimited resectionPrognosisMeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zefeng Shen Ping Chen Nannan Du Parishit A. Khadaroo Danyi Mao Lihu Gu |
spellingShingle |
Zefeng Shen Ping Chen Nannan Du Parishit A. Khadaroo Danyi Mao Lihu Gu Pancreaticoduodenectomy versus limited resection for duodenal gastrointestinal stromal tumors: a systematic review and meta-analysis BMC Surgery Duodenal gastrointestinal stromal tumors Pancreaticoduodenectomy Limited resection Prognosis Meta-analysis |
author_facet |
Zefeng Shen Ping Chen Nannan Du Parishit A. Khadaroo Danyi Mao Lihu Gu |
author_sort |
Zefeng Shen |
title |
Pancreaticoduodenectomy versus limited resection for duodenal gastrointestinal stromal tumors: a systematic review and meta-analysis |
title_short |
Pancreaticoduodenectomy versus limited resection for duodenal gastrointestinal stromal tumors: a systematic review and meta-analysis |
title_full |
Pancreaticoduodenectomy versus limited resection for duodenal gastrointestinal stromal tumors: a systematic review and meta-analysis |
title_fullStr |
Pancreaticoduodenectomy versus limited resection for duodenal gastrointestinal stromal tumors: a systematic review and meta-analysis |
title_full_unstemmed |
Pancreaticoduodenectomy versus limited resection for duodenal gastrointestinal stromal tumors: a systematic review and meta-analysis |
title_sort |
pancreaticoduodenectomy versus limited resection for duodenal gastrointestinal stromal tumors: a systematic review and meta-analysis |
publisher |
BMC |
series |
BMC Surgery |
issn |
1471-2482 |
publishDate |
2019-08-01 |
description |
Abstract Background By comparing the long-term prognostic outcomes after pancreaticoduodenectomy (PD) and limited resection (LR), this study aimed to investigate the optimal surgical modality for duodenal gastrointestinal stromal tumors (GISTs). Methods Two authors independently searched PubMed, Web of Science, Embase, and the Cochrane Library for published articles comparing the long-term prognostic and clinicopathological factors of duodenal GIST patients undergoing PD versus LR. Relevant information was extracted and analyzed. Results After screening, 10 items comprising 623 cases were eventually included. This meta-analysis explicitly indicated that PD treatment was associated with worse long-term prognosis (hazard ratio = 1.93; 95% confidence interval [CI], 1.39–2.69; p < 0.001; I2 = 0) and more complications (odds ratio [OR] = 2.90; 95% CI, 1.90–4.42; p < 0.001; I2 = 10%) than LR treatment. Nevertheless, for duodenal GISTs, PD was related to the following clinicopathological features: invasion of the second part of the duodenum (OR = 3.39; 95% CI, 1.69–6.79; p < 0.001; I2 = 50%), high-degree tumor mitosis (> 5/50 high-power fields; OR = 2.24; 95% CI, 1.42–3.52; p < 0.001; I2 = 0), and high-risk classification (OR = 3.17; 95% CI; 2.13–4.71; p < 0.001; I2 = 0). Conclusions Since PD is associated with worse long-term prognosis and more complications, its safety and efficacy should be ascertained. Our findings recommend the use of LR to obtain negative incision margins when conditions permit it. |
topic |
Duodenal gastrointestinal stromal tumors Pancreaticoduodenectomy Limited resection Prognosis Meta-analysis |
url |
http://link.springer.com/article/10.1186/s12893-019-0587-4 |
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