Novel Mutations in K13 Propeller Gene of Artemisinin-Resistant Plasmodium falciparum

Novel Mutations in K13 Propeller Gene of Artemisinin-Resistant Plasmodium falciparum

We looked for mutations in the Plasmodium falciparum K13 propeller gene of an artemisinin-resistant parasite on islands in Lake Victoria, Kenya, where transmission in 2012–2013 was high. The 4 new types of nonsynonymous, and 5 of synonymous, mutations we detected among 539 samples analyzed provide c...

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Main Authors: Rie Isozumi, Haruki Uemura, Isao Kimata, Yoshio Ichinose, John Logedi, Ahmeddin H. Omar, Akira Kaneko
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2015-03-01
Series:Emerging Infectious Diseases
Subjects:
Plasmodium falciparum
artemisinin
drug resistance
point mutation
parasites
malaria
Online Access:https://wwwnc.cdc.gov/eid/article/21/3/14-0898_article
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spelling doaj-7dacd133fee544c6ad4a8868dcd33c1a2020-11-24T23:08:02ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592015-03-0121349049210.3201/eid2103.140898Novel Mutations in K13 Propeller Gene of Artemisinin-Resistant Plasmodium falciparumRie IsozumiHaruki UemuraIsao KimataYoshio IchinoseJohn LogediAhmeddin H. OmarAkira KanekoWe looked for mutations in the Plasmodium falciparum K13 propeller gene of an artemisinin-resistant parasite on islands in Lake Victoria, Kenya, where transmission in 2012–2013 was high. The 4 new types of nonsynonymous, and 5 of synonymous, mutations we detected among 539 samples analyzed provide clues to understanding artemisinin-resistant parasites.https://wwwnc.cdc.gov/eid/article/21/3/14-0898_articlePlasmodium falciparumartemisinindrug resistancepoint mutationparasitesmalaria
collection DOAJ
language English
format Article
sources DOAJ
author Rie Isozumi
Haruki Uemura
Isao Kimata
Yoshio Ichinose
John Logedi
Ahmeddin H. Omar
Akira Kaneko
spellingShingle Rie Isozumi
Haruki Uemura
Isao Kimata
Yoshio Ichinose
John Logedi
Ahmeddin H. Omar
Akira Kaneko
Novel Mutations in K13 Propeller Gene of Artemisinin-Resistant Plasmodium falciparum
Emerging Infectious Diseases
Plasmodium falciparum
artemisinin
drug resistance
point mutation
parasites
malaria
author_facet Rie Isozumi
Haruki Uemura
Isao Kimata
Yoshio Ichinose
John Logedi
Ahmeddin H. Omar
Akira Kaneko
author_sort Rie Isozumi
title Novel Mutations in K13 Propeller Gene of Artemisinin-Resistant Plasmodium falciparum
title_short Novel Mutations in K13 Propeller Gene of Artemisinin-Resistant Plasmodium falciparum
title_full Novel Mutations in K13 Propeller Gene of Artemisinin-Resistant Plasmodium falciparum
title_fullStr Novel Mutations in K13 Propeller Gene of Artemisinin-Resistant Plasmodium falciparum
title_full_unstemmed Novel Mutations in K13 Propeller Gene of Artemisinin-Resistant Plasmodium falciparum
title_sort novel mutations in k13 propeller gene of artemisinin-resistant plasmodium falciparum
publisher Centers for Disease Control and Prevention
series Emerging Infectious Diseases
issn 1080-6040
1080-6059
publishDate 2015-03-01
description We looked for mutations in the Plasmodium falciparum K13 propeller gene of an artemisinin-resistant parasite on islands in Lake Victoria, Kenya, where transmission in 2012–2013 was high. The 4 new types of nonsynonymous, and 5 of synonymous, mutations we detected among 539 samples analyzed provide clues to understanding artemisinin-resistant parasites.
topic Plasmodium falciparum
artemisinin
drug resistance
point mutation
parasites
malaria
url https://wwwnc.cdc.gov/eid/article/21/3/14-0898_article
work_keys_str_mv AT rieisozumi novelmutationsink13propellergeneofartemisininresistantplasmodiumfalciparum
AT harukiuemura novelmutationsink13propellergeneofartemisininresistantplasmodiumfalciparum
AT isaokimata novelmutationsink13propellergeneofartemisininresistantplasmodiumfalciparum
AT yoshioichinose novelmutationsink13propellergeneofartemisininresistantplasmodiumfalciparum
AT johnlogedi novelmutationsink13propellergeneofartemisininresistantplasmodiumfalciparum
AT ahmeddinhomar novelmutationsink13propellergeneofartemisininresistantplasmodiumfalciparum
AT akirakaneko novelmutationsink13propellergeneofartemisininresistantplasmodiumfalciparum
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