The Enigma of the Adrenarche: Identifying the Early Life Mechanisms and Possible Role in Postnatal Brain Development

The Enigma of the Adrenarche: Identifying the Early Life Mechanisms and Possible Role in Postnatal Brain Development

Dehydroepiandrosterone (DHEA) and its sulfated metabolite (DHEAS) are dynamically regulated before birth and the onset of puberty. Yet, the origins and purpose of increasing DHEA[S] in postnatal development remain elusive. Here, we draw attention to this pre-pubertal surge from the adrenal gland—the...

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Bibliographic Details
Main Authors: Angela L. Cumberland, Jonathan J. Hirst, Emilio Badoer, Stefan A. Wudy, Ronda F. Greaves, Margaret Zacharin, David W. Walker
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
adrenarche
DHEA/DHEAS
adrenal androgens
neurosteroids
brain development
Online Access:https://www.mdpi.com/1422-0067/22/9/4296

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