Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate

Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate

A simple route for synthesis of ethyl 2-(3-methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate is developed. The present work involves condensation of 2-(2-nitrobenzamido)propanoic acid with ethyl anthranillate followed by the H2/Pd/C reduction to give the amino ester which upon hea...

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Main Authors: Naim H. Al-Said, Ayat M. Al-Sghair
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Molbank
Subjects:
benzo[e][1,4]diazepine
ferric chloride
cyclization
Online Access:http://www.mdpi.com/1422-8599/2013/4/M811
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spelling doaj-7db806df7e2f488bbea4971e25ab3d2b2020-11-24T20:40:35ZengMDPI AGMolbank1422-85992013-12-0120134M81110.3390/M811M811Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoateNaim H. Al-Said0Ayat M. Al-Sghair1Department of Chemistry, Jordan University of Science and Technology, Irbid 22110, JordanDepartment of Chemistry, Jordan University of Science and Technology, Irbid 22110, JordanA simple route for synthesis of ethyl 2-(3-methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate is developed. The present work involves condensation of 2-(2-nitrobenzamido)propanoic acid with ethyl anthranillate followed by the H2/Pd/C reduction to give the amino ester which upon heating in DMF in the presence of FeCl3 affords the title compound. The structure of the title compound was established on the basis of 1H-NMR, 13C-NMR and mass spectral data.http://www.mdpi.com/1422-8599/2013/4/M811benzo[e][1,4]diazepineferric chloridecyclization
collection DOAJ
language English
format Article
sources DOAJ
author Naim H. Al-Said
Ayat M. Al-Sghair
spellingShingle Naim H. Al-Said
Ayat M. Al-Sghair
Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate
Molbank
benzo[e][1,4]diazepine
ferric chloride
cyclization
author_facet Naim H. Al-Said
Ayat M. Al-Sghair
author_sort Naim H. Al-Said
title Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate
title_short Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate
title_full Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate
title_fullStr Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate
title_full_unstemmed Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate
title_sort ethyl 2-(3-methyl-5-oxo-4,5-dihydro-3h-benzo[e][1,4]diazepin-2-ylamino)benzoate
publisher MDPI AG
series Molbank
issn 1422-8599
publishDate 2013-12-01
description A simple route for synthesis of ethyl 2-(3-methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate is developed. The present work involves condensation of 2-(2-nitrobenzamido)propanoic acid with ethyl anthranillate followed by the H2/Pd/C reduction to give the amino ester which upon heating in DMF in the presence of FeCl3 affords the title compound. The structure of the title compound was established on the basis of 1H-NMR, 13C-NMR and mass spectral data.
topic benzo[e][1,4]diazepine
ferric chloride
cyclization
url http://www.mdpi.com/1422-8599/2013/4/M811
work_keys_str_mv AT naimhalsaid ethyl23methyl5oxo45dihydro3hbenzoe14diazepin2ylaminobenzoate
AT ayatmalsghair ethyl23methyl5oxo45dihydro3hbenzoe14diazepin2ylaminobenzoate
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