Identifying and Overcoming Mechanisms of PARP Inhibitor Resistance in Homologous Recombination Repair-Deficient and Repair-Proficient High Grade Serous Ovarian Cancer Cells

Identifying and Overcoming Mechanisms of PARP Inhibitor Resistance in Homologous Recombination Repair-Deficient and Repair-Proficient High Grade Serous Ovarian Cancer Cells

High grade serous ovarian cancer (HGSOC) is a major cause of female cancer mortality. The approval of poly (ADP-ribose) polymerase (PARP) inhibitors for clinical use has greatly improved treatment options for patients with homologous recombination repair (HRR)-deficient HGSOC, although the developme...

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Bibliographic Details
Main Authors: Miriam K. Gomez, Giuditta Illuzzi, Carlota Colomer, Michael Churchman, Robert L. Hollis, Mark J. O’Connor, Charlie Gourley, Elisabetta Leo, David W. Melton
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
PARP inhibitor
olaparib
resistance mechanism
DNA repair
WEE1 kinase
ovarian cancer
Online Access:https://www.mdpi.com/2072-6694/12/6/1503

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