Preoperative Gadoxetic Acid-Enhanced MRI Based Nomogram Improves Prediction of Early HCC Recurrence After Ablation Therapy
PurposeThis study aimed to identify preoperative gadoxetic acid-enhanced MRI features and establish a nomogram for predicting early recurrence (≤ 2 years) of hepatocellular carcinoma (HCC) after ablation therapy.MethodsA total of 160 patients who underwent gadoxetic acid-enhanced MRI and ablation HC...
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Frontiers Media S.A.
2021-05-01
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Series: | Frontiers in Oncology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.649682/full |
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doaj-7dc90f6ab4164d79808ec4894ffaa0a2 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chengguang Hu Chengguang Hu Yangda Song Yangda Song Jing Zhang Lin Dai Cuirong Tang Cuirong Tang Meng Li Meng Li Weijia Liao Yuchen Zhou Yikai Xu Yong-Yuan Zhang Yuanping Zhou |
spellingShingle |
Chengguang Hu Chengguang Hu Yangda Song Yangda Song Jing Zhang Lin Dai Cuirong Tang Cuirong Tang Meng Li Meng Li Weijia Liao Yuchen Zhou Yikai Xu Yong-Yuan Zhang Yuanping Zhou Preoperative Gadoxetic Acid-Enhanced MRI Based Nomogram Improves Prediction of Early HCC Recurrence After Ablation Therapy Frontiers in Oncology magnetic resonance imaging hepatocellular carcinoma nomogram prediction early recurrence ablation technique |
author_facet |
Chengguang Hu Chengguang Hu Yangda Song Yangda Song Jing Zhang Lin Dai Cuirong Tang Cuirong Tang Meng Li Meng Li Weijia Liao Yuchen Zhou Yikai Xu Yong-Yuan Zhang Yuanping Zhou |
author_sort |
Chengguang Hu |
title |
Preoperative Gadoxetic Acid-Enhanced MRI Based Nomogram Improves Prediction of Early HCC Recurrence After Ablation Therapy |
title_short |
Preoperative Gadoxetic Acid-Enhanced MRI Based Nomogram Improves Prediction of Early HCC Recurrence After Ablation Therapy |
title_full |
Preoperative Gadoxetic Acid-Enhanced MRI Based Nomogram Improves Prediction of Early HCC Recurrence After Ablation Therapy |
title_fullStr |
Preoperative Gadoxetic Acid-Enhanced MRI Based Nomogram Improves Prediction of Early HCC Recurrence After Ablation Therapy |
title_full_unstemmed |
Preoperative Gadoxetic Acid-Enhanced MRI Based Nomogram Improves Prediction of Early HCC Recurrence After Ablation Therapy |
title_sort |
preoperative gadoxetic acid-enhanced mri based nomogram improves prediction of early hcc recurrence after ablation therapy |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-05-01 |
description |
PurposeThis study aimed to identify preoperative gadoxetic acid-enhanced MRI features and establish a nomogram for predicting early recurrence (≤ 2 years) of hepatocellular carcinoma (HCC) after ablation therapy.MethodsA total of 160 patients who underwent gadoxetic acid-enhanced MRI and ablation HCC therapy from January 2015 to June 2018, were included retrospectively and divided into a training cohort (n = 112) and a validation cohort (n = 48). Independent clinical risk factors and gadoxetic acid-enhanced MRI features associated with early recurrence were identified by univariate and multivariate logistic regression analysis and used for construction of a nomogram. The performance of the nomogram was evaluated by discrimination, calibration, and clinical utility.ResultsAlpha-fetoprotein (AFP) level, tumor number, arterial peritumoral enhancement, satellite nodule and peritumoral hypointensity at hepatobiliary phases in the training cohort were identified as independent risk factors for early recurrence after ablation. A new nomogram that was constructed with these five features showed an area under the curve (AUC) of 0.843 (95%CI 0.771-0.916) and 0.835 (95%CI 0.713-0.956) in the training and validation cohort, respectively. The calibration curve and decision curve analysis (DCA) suggested that the nomogram had good consistency and clinical utility.ConclusionsA new nomogram that was constructed using four preoperative gadoxetic acid-enhanced MRI features and serum AFP level can predict the risk of early HCC recurrence after ablation therapy with AUC up to 0.843. The strong performance of this nomogram may help hepatologists to categorize patients’ recurrent risk to guide selecting treatment options and improve postoperative management. |
topic |
magnetic resonance imaging hepatocellular carcinoma nomogram prediction early recurrence ablation technique |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.649682/full |
work_keys_str_mv |
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doaj-7dc90f6ab4164d79808ec4894ffaa0a22021-05-21T13:41:55ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-05-011110.3389/fonc.2021.649682649682Preoperative Gadoxetic Acid-Enhanced MRI Based Nomogram Improves Prediction of Early HCC Recurrence After Ablation TherapyChengguang Hu0Chengguang Hu1Yangda Song2Yangda Song3Jing Zhang4Lin Dai5Cuirong Tang6Cuirong Tang7Meng Li8Meng Li9Weijia Liao10Yuchen Zhou11Yikai Xu12Yong-Yuan Zhang13Yuanping Zhou14Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaLaboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Guilin, ChinaDepartment of General Surgery, Hospital of Integrated TCM and Western Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaHBVtech, Germantown, MD, United StatesGuangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaPurposeThis study aimed to identify preoperative gadoxetic acid-enhanced MRI features and establish a nomogram for predicting early recurrence (≤ 2 years) of hepatocellular carcinoma (HCC) after ablation therapy.MethodsA total of 160 patients who underwent gadoxetic acid-enhanced MRI and ablation HCC therapy from January 2015 to June 2018, were included retrospectively and divided into a training cohort (n = 112) and a validation cohort (n = 48). Independent clinical risk factors and gadoxetic acid-enhanced MRI features associated with early recurrence were identified by univariate and multivariate logistic regression analysis and used for construction of a nomogram. The performance of the nomogram was evaluated by discrimination, calibration, and clinical utility.ResultsAlpha-fetoprotein (AFP) level, tumor number, arterial peritumoral enhancement, satellite nodule and peritumoral hypointensity at hepatobiliary phases in the training cohort were identified as independent risk factors for early recurrence after ablation. A new nomogram that was constructed with these five features showed an area under the curve (AUC) of 0.843 (95%CI 0.771-0.916) and 0.835 (95%CI 0.713-0.956) in the training and validation cohort, respectively. The calibration curve and decision curve analysis (DCA) suggested that the nomogram had good consistency and clinical utility.ConclusionsA new nomogram that was constructed using four preoperative gadoxetic acid-enhanced MRI features and serum AFP level can predict the risk of early HCC recurrence after ablation therapy with AUC up to 0.843. The strong performance of this nomogram may help hepatologists to categorize patients’ recurrent risk to guide selecting treatment options and improve postoperative management.https://www.frontiersin.org/articles/10.3389/fonc.2021.649682/fullmagnetic resonance imaginghepatocellular carcinomanomogrampredictionearly recurrenceablation technique |