Complexity Measures of Heart-Rate Variability in Amyotrophic Lateral Sclerosis with Alternative Pulmonary Capacities
Objective: the complexity of heart-rate variability (HRV) in amyotrophic lateral sclerosis (ALS) patients with different pulmonary capacities was evaluated. Methods: We set these according to their pulmonary capacity, and specifically forced vital capacity (FVC). We split the groups according to FVC...
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doaj-7dccd87881d246b4ac75b8597f8a21222021-01-29T00:05:04ZengMDPI AGEntropy1099-43002021-01-012315915910.3390/e23020159Complexity Measures of Heart-Rate Variability in Amyotrophic Lateral Sclerosis with Alternative Pulmonary CapacitiesRenata M. M. Pimentel0Celso Ferreira1Vitor Valenti2David M. Garner3Hugo Macedo4Acary S. Bulle Oliveira5Francisco Naildo Cardoso Leitão6Luiz Carlos de Abreu7Departament of Medicine, Federal University of Santo Paulo (UNIFESP), São Paulo 04024-002, BrazilDepartament of Medicine, Federal University of Santo Paulo (UNIFESP), São Paulo 04024-002, BrazilAutonomic Nervous System Center (CESNA) Sao Paulo State University, Marília 17525-900, BrazilCardiorespiratory Research Group, Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Headington, Oxford OX3 0BP, UKLaboratório de Delineamento de Estudo e Escrita Científica, Centro Universitário FMABC, Santo André 09060-650, BrazilDepartment of Neuromuscular Diseases, UNIFESP, São Paulo 04022-002, BrazilLaboratório de Delineamento de Estudo e Escrita Científica, Centro Universitário FMABC, Santo André 09060-650, BrazilDepartment of Integrated Health Education, Federal University of Espírito Santo (UFES), Vitória 29040-090, BrazilObjective: the complexity of heart-rate variability (HRV) in amyotrophic lateral sclerosis (ALS) patients with different pulmonary capacities was evaluated. Methods: We set these according to their pulmonary capacity, and specifically forced vital capacity (FVC). We split the groups according to FVC (FVC > 50% (<i>n</i> = 29) and FVC < 50% (<i>n</i> = 28)). In ALS, the presence of an FVC below 50% is indicative of noninvasive ventilation with two pressure levels and with the absence of other respiratory symptoms. As the number of subjects per group was different, we applied the unbalanced one-way analysis of variance (uANOVA1) test after three tests of normality, and effect size by Cohen’s <i>d</i> to assess parameter significance. Results: with regard to chaotic global analysis, CFP4 (<i>p</i> < 0.001; <i>d</i> = 0.91), CFP5 (<i>p</i> = 0.0022; <i>d</i> = 0.85), and CFP6 (<i>p</i> = 0.0009; <i>d</i> = 0.92) were enlarged. All entropies significantly increased. Shannon (<i>p</i> = 0.0005; <i>d</i> = 0.98), Renyi (<i>p</i> = 0.0002; <i>d</i> = 1.02), Tsallis (<i>p</i> = 0.0004; <i>d</i> = 0.99), approximate (<i>p</i> = 0.0005; <i>d</i> = 0.97), and sample (<i>p</i> < 0.0001; <i>d</i> = 1.22). Detrended fluctuation analysis (DFA) (<i>p</i> = 0.0358) and Higuchi fractal dimension (HFD) (<i>p</i> = 0.15) were statistically inconsequential between the two groups. Conclusions: HRV complexity in ALS subjects with different pulmonary capacities increased via chaotic global analysis, especially CFP5 and 3 out of 5 entropies.https://www.mdpi.com/1099-4300/23/2/159amyotrophic lateral sclerosisautonomic nervous systemcardiovascular physiologymotor neuron diseasenonlinear dynamics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Renata M. M. Pimentel Celso Ferreira Vitor Valenti David M. Garner Hugo Macedo Acary S. Bulle Oliveira Francisco Naildo Cardoso Leitão Luiz Carlos de Abreu |
spellingShingle |
Renata M. M. Pimentel Celso Ferreira Vitor Valenti David M. Garner Hugo Macedo Acary S. Bulle Oliveira Francisco Naildo Cardoso Leitão Luiz Carlos de Abreu Complexity Measures of Heart-Rate Variability in Amyotrophic Lateral Sclerosis with Alternative Pulmonary Capacities Entropy amyotrophic lateral sclerosis autonomic nervous system cardiovascular physiology motor neuron disease nonlinear dynamics |
author_facet |
Renata M. M. Pimentel Celso Ferreira Vitor Valenti David M. Garner Hugo Macedo Acary S. Bulle Oliveira Francisco Naildo Cardoso Leitão Luiz Carlos de Abreu |
author_sort |
Renata M. M. Pimentel |
title |
Complexity Measures of Heart-Rate Variability in Amyotrophic Lateral Sclerosis with Alternative Pulmonary Capacities |
title_short |
Complexity Measures of Heart-Rate Variability in Amyotrophic Lateral Sclerosis with Alternative Pulmonary Capacities |
title_full |
Complexity Measures of Heart-Rate Variability in Amyotrophic Lateral Sclerosis with Alternative Pulmonary Capacities |
title_fullStr |
Complexity Measures of Heart-Rate Variability in Amyotrophic Lateral Sclerosis with Alternative Pulmonary Capacities |
title_full_unstemmed |
Complexity Measures of Heart-Rate Variability in Amyotrophic Lateral Sclerosis with Alternative Pulmonary Capacities |
title_sort |
complexity measures of heart-rate variability in amyotrophic lateral sclerosis with alternative pulmonary capacities |
publisher |
MDPI AG |
series |
Entropy |
issn |
1099-4300 |
publishDate |
2021-01-01 |
description |
Objective: the complexity of heart-rate variability (HRV) in amyotrophic lateral sclerosis (ALS) patients with different pulmonary capacities was evaluated. Methods: We set these according to their pulmonary capacity, and specifically forced vital capacity (FVC). We split the groups according to FVC (FVC > 50% (<i>n</i> = 29) and FVC < 50% (<i>n</i> = 28)). In ALS, the presence of an FVC below 50% is indicative of noninvasive ventilation with two pressure levels and with the absence of other respiratory symptoms. As the number of subjects per group was different, we applied the unbalanced one-way analysis of variance (uANOVA1) test after three tests of normality, and effect size by Cohen’s <i>d</i> to assess parameter significance. Results: with regard to chaotic global analysis, CFP4 (<i>p</i> < 0.001; <i>d</i> = 0.91), CFP5 (<i>p</i> = 0.0022; <i>d</i> = 0.85), and CFP6 (<i>p</i> = 0.0009; <i>d</i> = 0.92) were enlarged. All entropies significantly increased. Shannon (<i>p</i> = 0.0005; <i>d</i> = 0.98), Renyi (<i>p</i> = 0.0002; <i>d</i> = 1.02), Tsallis (<i>p</i> = 0.0004; <i>d</i> = 0.99), approximate (<i>p</i> = 0.0005; <i>d</i> = 0.97), and sample (<i>p</i> < 0.0001; <i>d</i> = 1.22). Detrended fluctuation analysis (DFA) (<i>p</i> = 0.0358) and Higuchi fractal dimension (HFD) (<i>p</i> = 0.15) were statistically inconsequential between the two groups. Conclusions: HRV complexity in ALS subjects with different pulmonary capacities increased via chaotic global analysis, especially CFP5 and 3 out of 5 entropies. |
topic |
amyotrophic lateral sclerosis autonomic nervous system cardiovascular physiology motor neuron disease nonlinear dynamics |
url |
https://www.mdpi.com/1099-4300/23/2/159 |
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