Amnion signals are essential for mesoderm formation in primates
Human and murine embryonic development has disparities, highlighting the need for primate systems. Here, the authors construct a post-implantation transcriptional atlas from non-human primate embryos and show ISL1 controls a gene regulatory network in the amnion required for mesoderm formation.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25186-2 |
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doaj-7dccdc1bc5d94178bbec12844860f1f92021-08-29T11:38:04ZengNature Publishing GroupNature Communications2041-17232021-08-0112111410.1038/s41467-021-25186-2Amnion signals are essential for mesoderm formation in primatesRan Yang0Alexander Goedel1Yu Kang2Chenyang Si3Chu Chu4Yi Zheng5Zhenzhen Chen6Peter J. Gruber7Yao Xiao8Chikai Zhou9Nevin Witman10Elif Eroglu11Chuen-Yan Leung12Yongchang Chen13Jianping Fu14Weizhi Ji15Fredrik Lanner16Yuyu Niu17Kenneth R. Chien18Department of Cell and Molecular Biology, Karolinska InstitutetDepartment of Cell and Molecular Biology, Karolinska InstitutetYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and TechnologyYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and TechnologyYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and TechnologyDepartment of Mechanical Engineering, University of MichiganYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and TechnologyDepartment of Cell and Molecular Biology, Karolinska InstitutetDepartment of Cell and Molecular Biology, Karolinska InstitutetDepartment of Cell and Molecular Biology, Karolinska InstitutetDepartment of Cell and Molecular Biology, Karolinska InstitutetDepartment of Cell and Molecular Biology, Karolinska InstitutetDepartment of Cell and Molecular Biology, Karolinska InstitutetYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and TechnologyDepartment of Mechanical Engineering, University of MichiganYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and TechnologyDepartment of Clinical Sciences, Intervention and Technology, Karolinska InstitutetYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and TechnologyDepartment of Cell and Molecular Biology, Karolinska InstitutetHuman and murine embryonic development has disparities, highlighting the need for primate systems. Here, the authors construct a post-implantation transcriptional atlas from non-human primate embryos and show ISL1 controls a gene regulatory network in the amnion required for mesoderm formation.https://doi.org/10.1038/s41467-021-25186-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ran Yang Alexander Goedel Yu Kang Chenyang Si Chu Chu Yi Zheng Zhenzhen Chen Peter J. Gruber Yao Xiao Chikai Zhou Nevin Witman Elif Eroglu Chuen-Yan Leung Yongchang Chen Jianping Fu Weizhi Ji Fredrik Lanner Yuyu Niu Kenneth R. Chien |
| spellingShingle |
Ran Yang Alexander Goedel Yu Kang Chenyang Si Chu Chu Yi Zheng Zhenzhen Chen Peter J. Gruber Yao Xiao Chikai Zhou Nevin Witman Elif Eroglu Chuen-Yan Leung Yongchang Chen Jianping Fu Weizhi Ji Fredrik Lanner Yuyu Niu Kenneth R. Chien Amnion signals are essential for mesoderm formation in primates Nature Communications |
| author_facet |
Ran Yang Alexander Goedel Yu Kang Chenyang Si Chu Chu Yi Zheng Zhenzhen Chen Peter J. Gruber Yao Xiao Chikai Zhou Nevin Witman Elif Eroglu Chuen-Yan Leung Yongchang Chen Jianping Fu Weizhi Ji Fredrik Lanner Yuyu Niu Kenneth R. Chien |
| author_sort |
Ran Yang |
| title |
Amnion signals are essential for mesoderm formation in primates |
| title_short |
Amnion signals are essential for mesoderm formation in primates |
| title_full |
Amnion signals are essential for mesoderm formation in primates |
| title_fullStr |
Amnion signals are essential for mesoderm formation in primates |
| title_full_unstemmed |
Amnion signals are essential for mesoderm formation in primates |
| title_sort |
amnion signals are essential for mesoderm formation in primates |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-08-01 |
| description |
Human and murine embryonic development has disparities, highlighting the need for primate systems. Here, the authors construct a post-implantation transcriptional atlas from non-human primate embryos and show ISL1 controls a gene regulatory network in the amnion required for mesoderm formation. |
| url |
https://doi.org/10.1038/s41467-021-25186-2 |
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