The predictive value of factor V Leiden, prothrombin G20210A and MTHFR C677T Gene mutations on the location of venous thromboembolism
Objective: In the present study, we aimed to consider the relation between the manifestations of venous thromboembolism (VTE) and gene mutations including factor V Leiden (FVL), prothrombin G20210A and MTHFR C677T. Methods: One hundred and forty four patients with idiopathic VTE were enrolled in t...
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doaj-7dd8034aec4c42cab24c29d439a2c2342020-11-25T01:05:57ZengDicle University Medical SchoolDicle Medical Journal 1300-29451308-98892015-12-0142446747110.5798/diclemedj.0921.2015.04.0610The predictive value of factor V Leiden, prothrombin G20210A and MTHFR C677T Gene mutations on the location of venous thromboembolismMuammer Bilici 0İbrahim İlker Öz 1Sevil Uygun İlikhan2Müzeyyen Arslaner 3Elif Kahraman4Beyza Kılavuz5Zeynep Özdamar 6Şehmus Ertop 7İç Hastalıkları Anabilim Dalı, Bülent Ecevit Üniversitesi, Zonguldak, TürkiyeRadyoloji Anabilim Dalı, Bülent Ecevit Üniversitesi, Zonguldak, Türkiyeİç Hastalıkları Anabilim Dalı, Bülent Ecevit Üniversitesi, Zonguldak, TürkiyeHematoloji Bilim Dalı, Bülent Ecevit Üniversitesi, Zonguldak, Türkiyeİç Hastalıkları Anabilim Dalı, Bülent Ecevit Üniversitesi, Zonguldak, Türkiyeİç Hastalıkları Anabilim Dalı, Bülent Ecevit Üniversitesi, Zonguldak, Türkiyeİç Hastalıkları Anabilim Dalı, Bülent Ecevit Üniversitesi, Zonguldak, TürkiyeHematoloji Bilim Dalı, Bülent Ecevit Üniversitesi, Zonguldak, Türkiye Objective: In the present study, we aimed to consider the relation between the manifestations of venous thromboembolism (VTE) and gene mutations including factor V Leiden (FVL), prothrombin G20210A and MTHFR C677T. Methods: One hundred and forty four patients with idiopathic VTE were enrolled in this study. The data of patients were obtained from the medical records in hospital information system. The patients were grouped according to the location of VTE. In all subjects FVL, prothrombin G20210A, and MTHFR C677T were analyzed by specific polymerase chain reactions and restriction enzymes. Univariate and multivariate analysis were used to evaluate the relation between the groups and the gene mutations including factor V Leiden (FVL), prothrombin G20210A and MTHFR C677T. Results: The mean age of patients was 41.16 ± 13.23 years and the male / female ratio was 1.18. Among the patients with VTE, 44 (30.6%) had only DVT, 41 (28.5%) had only PE, 26 (18.1%) had both DVT and PE, 23 (16%) had cerebral veins thrombosis (CVT) and 10 (6.9%) had abdominal vein thrombosis The prevalence was found to be 46.5% for FVL, 13.2% for prothrombin G20210A and 45.1% for MTHFR C677T gene mutation among patients. There was no statistically difference between the manifestations of VTE regarding the gene mutations (p>0,05). Conclusion: The findings of this study suggest that gene mutations including factor V Leiden (FVL), prothrombin G20210A and MTHFR C677T are not sufficient to determine the location of VTE.http://www.diclemedj.org/upload/sayi/58/Dicle%20Med%20J-02578.pdfVenous thromboembolism; factor V Leiden; prothrombin G20210A; MTHFR C677T |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Muammer Bilici İbrahim İlker Öz Sevil Uygun İlikhan Müzeyyen Arslaner Elif Kahraman Beyza Kılavuz Zeynep Özdamar Şehmus Ertop |
spellingShingle |
Muammer Bilici İbrahim İlker Öz Sevil Uygun İlikhan Müzeyyen Arslaner Elif Kahraman Beyza Kılavuz Zeynep Özdamar Şehmus Ertop The predictive value of factor V Leiden, prothrombin G20210A and MTHFR C677T Gene mutations on the location of venous thromboembolism Dicle Medical Journal Venous thromboembolism; factor V Leiden; prothrombin G20210A; MTHFR C677T |
author_facet |
Muammer Bilici İbrahim İlker Öz Sevil Uygun İlikhan Müzeyyen Arslaner Elif Kahraman Beyza Kılavuz Zeynep Özdamar Şehmus Ertop |
author_sort |
Muammer Bilici |
title |
The predictive value of factor V Leiden, prothrombin G20210A and MTHFR C677T Gene mutations on the location of venous thromboembolism |
title_short |
The predictive value of factor V Leiden, prothrombin G20210A and MTHFR C677T Gene mutations on the location of venous thromboembolism |
title_full |
The predictive value of factor V Leiden, prothrombin G20210A and MTHFR C677T Gene mutations on the location of venous thromboembolism |
title_fullStr |
The predictive value of factor V Leiden, prothrombin G20210A and MTHFR C677T Gene mutations on the location of venous thromboembolism |
title_full_unstemmed |
The predictive value of factor V Leiden, prothrombin G20210A and MTHFR C677T Gene mutations on the location of venous thromboembolism |
title_sort |
predictive value of factor v leiden, prothrombin g20210a and mthfr c677t gene mutations on the location of venous thromboembolism |
publisher |
Dicle University Medical School |
series |
Dicle Medical Journal |
issn |
1300-2945 1308-9889 |
publishDate |
2015-12-01 |
description |
Objective: In the present study, we aimed to consider the relation between the manifestations of venous thromboembolism (VTE) and gene mutations including factor V Leiden (FVL), prothrombin G20210A and MTHFR C677T.
Methods: One hundred and forty four patients with idiopathic VTE were enrolled in this study. The data of patients were obtained from the medical records in hospital information system. The patients were grouped according to the location of VTE. In all subjects FVL, prothrombin G20210A, and MTHFR C677T were analyzed by specific polymerase chain reactions and restriction enzymes. Univariate and multivariate analysis were used to evaluate the relation between the groups and the gene mutations including factor V Leiden (FVL), prothrombin G20210A and MTHFR C677T.
Results: The mean age of patients was 41.16 ± 13.23 years and the male / female ratio was 1.18. Among the patients with VTE, 44 (30.6%) had only DVT, 41 (28.5%) had only PE, 26 (18.1%) had both DVT and PE, 23 (16%) had cerebral veins thrombosis (CVT) and 10 (6.9%) had abdominal vein thrombosis The prevalence was found to be 46.5% for FVL, 13.2% for prothrombin G20210A and 45.1% for MTHFR C677T gene mutation among patients. There was no statistically difference between the manifestations of VTE regarding the gene mutations (p>0,05).
Conclusion: The findings of this study suggest that gene mutations including factor V Leiden (FVL), prothrombin G20210A and MTHFR C677T are not sufficient to determine the location of VTE. |
topic |
Venous thromboembolism; factor V Leiden; prothrombin G20210A; MTHFR C677T |
url |
http://www.diclemedj.org/upload/sayi/58/Dicle%20Med%20J-02578.pdf |
work_keys_str_mv |
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