Serum interleukin-6 and tumor necrosis factor-α are associated with early graft regeneration after living donor liver transplantation.
Liver graft regeneration is orchestrated by specific and sequential stimuli, including hepatocyte growth factors, cytokines, and catecholamines. We evaluated the association between preoperative serum cytokines and early liver graft regeneration in human living donor liver transplantation (LDLT).We...
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doaj-7dd96e4258f34202aae5c6c31e31970a2020-11-25T01:46:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01134e019526210.1371/journal.pone.0195262Serum interleukin-6 and tumor necrosis factor-α are associated with early graft regeneration after living donor liver transplantation.Min Suk ChaeKwang Uck MoonHyun Sik ChungChul Soo ParkJaemin LeeJong Ho ChoiSang Hyun HongLiver graft regeneration is orchestrated by specific and sequential stimuli, including hepatocyte growth factors, cytokines, and catecholamines. We evaluated the association between preoperative serum cytokines and early liver graft regeneration in human living donor liver transplantation (LDLT).We retrospectively reviewed the data of adult patients who underwent LDLT from January 2010 to December 2014. Serum cytokines, including interleukin (IL)-2, 6, 10, 12, 17, interferon (IFN)-γ and tumor necrosis factor (TNF)-α were measured in the recipients 1 day before surgery and on postoperative day (POD) 7. Liver graft volume was estimated using abdominal computed tomography images of the donors and recipients.In total, 226 patients were analyzed in this study. Median preoperative levels of serum cytokines were as follows: IL-2, 0.1 (0.1-1.6) pg/mL; IL-6, 7.3 (0.1-30.2) pg/mL; IL-10, 0.5 (0.1-11.0) pg/mL; IL-12, 0.1 (0.1-0.1) pg/mL; IL-17, 2.0 (0.1-16.4) pg/mL; IFN-γ, 3.2 (0.1-16.0) pg/mL; and TNF-α, 9.8 (5.4-17.9) pg/mL. Higher preoperative serum levels of IL-6, IL-10, and TNF-α, dichotomized at the median, were associated with increased relative liver volumes by POD 7. Multivariate analysis revealed that higher levels of serum IL-6 and TNF-α were independently associated with increased graft volume during the first 1 week after LDLT, based on the lower levels of those cytokines.IL-6 and TNF-α were important mediators of the success of early graft regeneration in patients who underwent LDLT.http://europepmc.org/articles/PMC5896938?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Min Suk Chae Kwang Uck Moon Hyun Sik Chung Chul Soo Park Jaemin Lee Jong Ho Choi Sang Hyun Hong |
spellingShingle |
Min Suk Chae Kwang Uck Moon Hyun Sik Chung Chul Soo Park Jaemin Lee Jong Ho Choi Sang Hyun Hong Serum interleukin-6 and tumor necrosis factor-α are associated with early graft regeneration after living donor liver transplantation. PLoS ONE |
author_facet |
Min Suk Chae Kwang Uck Moon Hyun Sik Chung Chul Soo Park Jaemin Lee Jong Ho Choi Sang Hyun Hong |
author_sort |
Min Suk Chae |
title |
Serum interleukin-6 and tumor necrosis factor-α are associated with early graft regeneration after living donor liver transplantation. |
title_short |
Serum interleukin-6 and tumor necrosis factor-α are associated with early graft regeneration after living donor liver transplantation. |
title_full |
Serum interleukin-6 and tumor necrosis factor-α are associated with early graft regeneration after living donor liver transplantation. |
title_fullStr |
Serum interleukin-6 and tumor necrosis factor-α are associated with early graft regeneration after living donor liver transplantation. |
title_full_unstemmed |
Serum interleukin-6 and tumor necrosis factor-α are associated with early graft regeneration after living donor liver transplantation. |
title_sort |
serum interleukin-6 and tumor necrosis factor-α are associated with early graft regeneration after living donor liver transplantation. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2018-01-01 |
description |
Liver graft regeneration is orchestrated by specific and sequential stimuli, including hepatocyte growth factors, cytokines, and catecholamines. We evaluated the association between preoperative serum cytokines and early liver graft regeneration in human living donor liver transplantation (LDLT).We retrospectively reviewed the data of adult patients who underwent LDLT from January 2010 to December 2014. Serum cytokines, including interleukin (IL)-2, 6, 10, 12, 17, interferon (IFN)-γ and tumor necrosis factor (TNF)-α were measured in the recipients 1 day before surgery and on postoperative day (POD) 7. Liver graft volume was estimated using abdominal computed tomography images of the donors and recipients.In total, 226 patients were analyzed in this study. Median preoperative levels of serum cytokines were as follows: IL-2, 0.1 (0.1-1.6) pg/mL; IL-6, 7.3 (0.1-30.2) pg/mL; IL-10, 0.5 (0.1-11.0) pg/mL; IL-12, 0.1 (0.1-0.1) pg/mL; IL-17, 2.0 (0.1-16.4) pg/mL; IFN-γ, 3.2 (0.1-16.0) pg/mL; and TNF-α, 9.8 (5.4-17.9) pg/mL. Higher preoperative serum levels of IL-6, IL-10, and TNF-α, dichotomized at the median, were associated with increased relative liver volumes by POD 7. Multivariate analysis revealed that higher levels of serum IL-6 and TNF-α were independently associated with increased graft volume during the first 1 week after LDLT, based on the lower levels of those cytokines.IL-6 and TNF-α were important mediators of the success of early graft regeneration in patients who underwent LDLT. |
url |
http://europepmc.org/articles/PMC5896938?pdf=render |
work_keys_str_mv |
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