Membrane transporter data to support kinetically-informed chemical risk assessment using non-animal methods: Scientific and regulatory perspectives
Humans are continuously exposed to low levels of thousands of industrial chemicals, most of which are poorly characterised in terms of their potential toxicity. The new paradigm in chemical risk assessment (CRA) aims to rely on animal-free testing, with kinetics being a key determinant of toxicity w...
Main Authors: | Laure-Alix Clerbaux, Alicia Paini, Annie Lumen, Hanan Osman-Ponchet, Andrew P. Worth, Olivier Fardel |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2019-05-01
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Series: | Environment International |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412018324930 |
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