Associative Memory Extinction Is Accompanied by Decayed Plasticity at Motor Cortical Neurons and Persistent Plasticity at Sensory Cortical Neurons
Associative memory is essential for cognition, in which associative memory cells and their plasticity presumably play important roles. The mechanism underlying associative memory extinction vs. maintenance remains unclear, which we have studied in a mouse model of cross-modal associative learning. P...
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doaj-7ddfd05033284473921bd8db889869042020-11-25T00:06:22ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022017-06-011110.3389/fncel.2017.00168268768Associative Memory Extinction Is Accompanied by Decayed Plasticity at Motor Cortical Neurons and Persistent Plasticity at Sensory Cortical NeuronsRui Guo0Rongjing Ge1Shidi Zhao2Yulong Liu3Xin Zhao4Li Huang5Sodong Guan6Wei Lu7Shan Cui8Shirlene Wang9Jin-Hui Wang10Jin-Hui Wang11Jin-Hui Wang12Jin-Hui Wang13Department of Pathophysiology, Bengbu Medical CollegeAnhui, ChinaDepartment of Pathophysiology, Bengbu Medical CollegeAnhui, ChinaDepartment of Pathophysiology, Bengbu Medical CollegeAnhui, ChinaDepartment of Pathophysiology, Bengbu Medical CollegeAnhui, ChinaDepartment of Pathophysiology, Bengbu Medical CollegeAnhui, ChinaDepartment of Pathophysiology, Bengbu Medical CollegeAnhui, ChinaDepartment of Pathophysiology, Bengbu Medical CollegeAnhui, ChinaSchool of Pharmacy, Qingdao UniversityQingdao, ChinaBrain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of SciencesBeijing, ChinaDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern UniversityChicago, IL, United StatesDepartment of Pathophysiology, Bengbu Medical CollegeAnhui, ChinaSchool of Pharmacy, Qingdao UniversityQingdao, ChinaBrain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of SciencesBeijing, ChinaDepartment of Biology, University of Chinese Academy of SciencesBeijing, ChinaAssociative memory is essential for cognition, in which associative memory cells and their plasticity presumably play important roles. The mechanism underlying associative memory extinction vs. maintenance remains unclear, which we have studied in a mouse model of cross-modal associative learning. Paired whisker and olfaction stimulations lead to a full establishment of odorant-induced whisker motion in training day 10, which almost disappears if paired stimulations are not given in a week, and then recovers after paired stimulation for an additional day. In mice that show associative memory, extinction and recovery, we have analyzed the dynamical plasticity of glutamatergic neurons in layers II–III of the barrel cortex and layers IV–V of the motor cortex. Compared with control mice, the rate of evoked spikes as well as the amplitude and frequency of excitatory postsynaptic currents increase, whereas the amplitude and frequency of inhibitory postsynaptic currents (IPSC) decrease at training day 10 in associative memory mice. Without paired training for a week, these plastic changes are persistent in the barrel cortex and decayed in the motor cortex. If paired training is given for an additional day to revoke associative memory, neuronal plasticity recovers in the motor cortex. Our study indicates persistent neuronal plasticity in the barrel cortex for cross-modal memory maintenance as well as the dynamical change of neuronal plasticity in the motor cortex for memory retrieval and extinction. In other words, the sensory cortices are essential for long-term memory while the behavior-related cortices with the inability of memory retrieval are correlated to memory extinction.http://journal.frontiersin.org/article/10.3389/fncel.2017.00168/fulllearningmemoryglutamateGABAneuronsynapse |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rui Guo Rongjing Ge Shidi Zhao Yulong Liu Xin Zhao Li Huang Sodong Guan Wei Lu Shan Cui Shirlene Wang Jin-Hui Wang Jin-Hui Wang Jin-Hui Wang Jin-Hui Wang |
spellingShingle |
Rui Guo Rongjing Ge Shidi Zhao Yulong Liu Xin Zhao Li Huang Sodong Guan Wei Lu Shan Cui Shirlene Wang Jin-Hui Wang Jin-Hui Wang Jin-Hui Wang Jin-Hui Wang Associative Memory Extinction Is Accompanied by Decayed Plasticity at Motor Cortical Neurons and Persistent Plasticity at Sensory Cortical Neurons Frontiers in Cellular Neuroscience learning memory glutamate GABA neuron synapse |
author_facet |
Rui Guo Rongjing Ge Shidi Zhao Yulong Liu Xin Zhao Li Huang Sodong Guan Wei Lu Shan Cui Shirlene Wang Jin-Hui Wang Jin-Hui Wang Jin-Hui Wang Jin-Hui Wang |
author_sort |
Rui Guo |
title |
Associative Memory Extinction Is Accompanied by Decayed Plasticity at Motor Cortical Neurons and Persistent Plasticity at Sensory Cortical Neurons |
title_short |
Associative Memory Extinction Is Accompanied by Decayed Plasticity at Motor Cortical Neurons and Persistent Plasticity at Sensory Cortical Neurons |
title_full |
Associative Memory Extinction Is Accompanied by Decayed Plasticity at Motor Cortical Neurons and Persistent Plasticity at Sensory Cortical Neurons |
title_fullStr |
Associative Memory Extinction Is Accompanied by Decayed Plasticity at Motor Cortical Neurons and Persistent Plasticity at Sensory Cortical Neurons |
title_full_unstemmed |
Associative Memory Extinction Is Accompanied by Decayed Plasticity at Motor Cortical Neurons and Persistent Plasticity at Sensory Cortical Neurons |
title_sort |
associative memory extinction is accompanied by decayed plasticity at motor cortical neurons and persistent plasticity at sensory cortical neurons |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular Neuroscience |
issn |
1662-5102 |
publishDate |
2017-06-01 |
description |
Associative memory is essential for cognition, in which associative memory cells and their plasticity presumably play important roles. The mechanism underlying associative memory extinction vs. maintenance remains unclear, which we have studied in a mouse model of cross-modal associative learning. Paired whisker and olfaction stimulations lead to a full establishment of odorant-induced whisker motion in training day 10, which almost disappears if paired stimulations are not given in a week, and then recovers after paired stimulation for an additional day. In mice that show associative memory, extinction and recovery, we have analyzed the dynamical plasticity of glutamatergic neurons in layers II–III of the barrel cortex and layers IV–V of the motor cortex. Compared with control mice, the rate of evoked spikes as well as the amplitude and frequency of excitatory postsynaptic currents increase, whereas the amplitude and frequency of inhibitory postsynaptic currents (IPSC) decrease at training day 10 in associative memory mice. Without paired training for a week, these plastic changes are persistent in the barrel cortex and decayed in the motor cortex. If paired training is given for an additional day to revoke associative memory, neuronal plasticity recovers in the motor cortex. Our study indicates persistent neuronal plasticity in the barrel cortex for cross-modal memory maintenance as well as the dynamical change of neuronal plasticity in the motor cortex for memory retrieval and extinction. In other words, the sensory cortices are essential for long-term memory while the behavior-related cortices with the inability of memory retrieval are correlated to memory extinction. |
topic |
learning memory glutamate GABA neuron synapse |
url |
http://journal.frontiersin.org/article/10.3389/fncel.2017.00168/full |
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