Aptamer-Functionalized Natural Protein-Based Polymers as Innovative Biomaterials
Biomaterials science is one of the most rapidly evolving fields in biomedicine. However, although novel biomaterials have achieved well-defined goals, such as the production of devices with improved biocompatibility and mechanical properties, their development could be more ambitious. Indeed, the in...
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doaj-7de034ebb08549e38aa43bb8550266c62020-11-25T04:06:19ZengMDPI AGPharmaceutics1999-49232020-11-01121115111510.3390/pharmaceutics12111115Aptamer-Functionalized Natural Protein-Based Polymers as Innovative BiomaterialsAlessandra Girotti0Sara Escalera-Anzola1Irene Alonso-Sampedro2Juan González-Valdivieso3F. Javier Arias4BIOFORGE Research Group (Group for Advanced Materials and Nanobiotechnology), CIBER-BBN, University of Valladolid, LUCIA Building, 47011 Valladolid, SpainRecombinant Biomaterials Research Group, University of Valladolid, LUCIA Building, 47011 Valladolid, SpainRecombinant Biomaterials Research Group, University of Valladolid, LUCIA Building, 47011 Valladolid, SpainRecombinant Biomaterials Research Group, University of Valladolid, LUCIA Building, 47011 Valladolid, SpainRecombinant Biomaterials Research Group, University of Valladolid, LUCIA Building, 47011 Valladolid, SpainBiomaterials science is one of the most rapidly evolving fields in biomedicine. However, although novel biomaterials have achieved well-defined goals, such as the production of devices with improved biocompatibility and mechanical properties, their development could be more ambitious. Indeed, the integration of active targeting strategies has been shown to allow spatiotemporal control of cell–material interactions, thus leading to more specific and better-performing devices. This manuscript reviews recent advances that have led to enhanced biomaterials resulting from the use of natural structural macromolecules. In this regard, several structural macromolecules have been adapted or modified using biohybrid approaches for use in both regenerative medicine and therapeutic delivery. The integration of structural and functional features and aptamer targeting, although still incipient, has already shown its ability and wide-reaching potential. In this review, we discuss aptamer-functionalized hybrid protein-based or polymeric biomaterials derived from structural macromolecules, with a focus on bioresponsive/bioactive systems.https://www.mdpi.com/1999-4923/12/11/1115biomaterialsaptamerstargetingnatural polymersbiomedicinebio-targeting |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alessandra Girotti Sara Escalera-Anzola Irene Alonso-Sampedro Juan González-Valdivieso F. Javier Arias |
spellingShingle |
Alessandra Girotti Sara Escalera-Anzola Irene Alonso-Sampedro Juan González-Valdivieso F. Javier Arias Aptamer-Functionalized Natural Protein-Based Polymers as Innovative Biomaterials Pharmaceutics biomaterials aptamers targeting natural polymers biomedicine bio-targeting |
author_facet |
Alessandra Girotti Sara Escalera-Anzola Irene Alonso-Sampedro Juan González-Valdivieso F. Javier Arias |
author_sort |
Alessandra Girotti |
title |
Aptamer-Functionalized Natural Protein-Based Polymers as Innovative Biomaterials |
title_short |
Aptamer-Functionalized Natural Protein-Based Polymers as Innovative Biomaterials |
title_full |
Aptamer-Functionalized Natural Protein-Based Polymers as Innovative Biomaterials |
title_fullStr |
Aptamer-Functionalized Natural Protein-Based Polymers as Innovative Biomaterials |
title_full_unstemmed |
Aptamer-Functionalized Natural Protein-Based Polymers as Innovative Biomaterials |
title_sort |
aptamer-functionalized natural protein-based polymers as innovative biomaterials |
publisher |
MDPI AG |
series |
Pharmaceutics |
issn |
1999-4923 |
publishDate |
2020-11-01 |
description |
Biomaterials science is one of the most rapidly evolving fields in biomedicine. However, although novel biomaterials have achieved well-defined goals, such as the production of devices with improved biocompatibility and mechanical properties, their development could be more ambitious. Indeed, the integration of active targeting strategies has been shown to allow spatiotemporal control of cell–material interactions, thus leading to more specific and better-performing devices. This manuscript reviews recent advances that have led to enhanced biomaterials resulting from the use of natural structural macromolecules. In this regard, several structural macromolecules have been adapted or modified using biohybrid approaches for use in both regenerative medicine and therapeutic delivery. The integration of structural and functional features and aptamer targeting, although still incipient, has already shown its ability and wide-reaching potential. In this review, we discuss aptamer-functionalized hybrid protein-based or polymeric biomaterials derived from structural macromolecules, with a focus on bioresponsive/bioactive systems. |
topic |
biomaterials aptamers targeting natural polymers biomedicine bio-targeting |
url |
https://www.mdpi.com/1999-4923/12/11/1115 |
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