Repetitive Transcranial Magnetic Stimulation (rTMS) Improves Facial Affect Recognition in Schizophrenia
Objective: Facial affect recognition, a basic building block of social cognition, is often impaired in schizophrenia. Poor facial affect recognition is closely related to poor functional outcome; however, neither social cognitive impairments nor functional outcome are sufficiently improved by antips...
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doaj-7de8e4cabeba49bb9d22c59ddcd76d1c2021-03-18T04:37:50ZengElsevierBrain Stimulation1935-861X2014-07-0174559563Repetitive Transcranial Magnetic Stimulation (rTMS) Improves Facial Affect Recognition in SchizophreniaWolfgang Wölwer0Agnes Lowe1Jürgen Brinkmeyer2Marcus Streit3Mareke Habakuck4Marcus W. Agelink5Arian Mobascher6Wolfgang Gaebel7Joachim Cordes8Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University Düsseldorf, Bergische Landstrasse 2, 40629 Düsseldorf, Germany; Corresponding author. Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University Düsseldorf, LVR-Klinikum Düsseldorf, Bergische Landstrasse 2, 40629 Düsseldorf, Germany. Tel.: +49 211 9222002; fax: +49 211 9222020.Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University Düsseldorf, Bergische Landstrasse 2, 40629 Düsseldorf, GermanyDepartment of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University Düsseldorf, Bergische Landstrasse 2, 40629 Düsseldorf, GermanyDepartment of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University Düsseldorf, Bergische Landstrasse 2, 40629 Düsseldorf, GermanyDepartment of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University Düsseldorf, Bergische Landstrasse 2, 40629 Düsseldorf, GermanyDepartment of Psychiatry, Psychotherapy and Preventive Medicine, Ruhr-University Bochum, Alexandrinenstr. 1-3, 44791 Bochum, GermanyDepartment of Psychiatry and Psychotherapy, Johannes Gutenberg-University Mainz, Untere Zahlbacher Str. 8, 55131 Mainz, GermanyDepartment of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University Düsseldorf, Bergische Landstrasse 2, 40629 Düsseldorf, GermanyDepartment of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University Düsseldorf, Bergische Landstrasse 2, 40629 Düsseldorf, GermanyObjective: Facial affect recognition, a basic building block of social cognition, is often impaired in schizophrenia. Poor facial affect recognition is closely related to poor functional outcome; however, neither social cognitive impairments nor functional outcome are sufficiently improved by antipsychotic drug treatment alone. Adjunctive repetitive transcranial magnetic stimulation (rTMS) has been shown to enhance cognitive functioning in both healthy individuals and in people with neuropsychiatric disorders and to ameliorate clinical symptoms in psychiatric disorders, but its effects on social cognitive impairments in schizophrenia have not yet been studied. Therefore, we evaluated the effects of sham-controlled rTMS on facial affect recognition in patients with chronic schizophrenia. Method: Inpatients (N = 36) on stable antipsychotic treatment were randomly assigned to double-blind high-frequency (10 Hz) rTMS or sham stimulation for a total of ten sessions over two weeks. In the verum group, each session consisted of 10 000 stimuli (20 trains of 5 s) applied over the left dorsolateral prefrontal cortex at 110% of motor threshold. Facial affect recognition was assessed before (T0) and after (T1) the ten sessions. Results: Facial affect recognition improved significantly more after rTMS (accuracy change: mean = 8.9%, SD = 6.0%) than after sham stimulation (mean = 1.6%, SD = 3.5; Cohen's d = 1.45). There was no correlation with clinical improvement. Conclusion: Our results indicate that prefrontal 10 Hz rTMS stimulation may help to ameliorate impaired facial affect recognition in schizophrenia.http://www.sciencedirect.com/science/article/pii/S1935861X14001703SchizophreniaFacial affect recognitionRepetitive transcranial magnetic stimulation (rTMS) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wolfgang Wölwer Agnes Lowe Jürgen Brinkmeyer Marcus Streit Mareke Habakuck Marcus W. Agelink Arian Mobascher Wolfgang Gaebel Joachim Cordes |
spellingShingle |
Wolfgang Wölwer Agnes Lowe Jürgen Brinkmeyer Marcus Streit Mareke Habakuck Marcus W. Agelink Arian Mobascher Wolfgang Gaebel Joachim Cordes Repetitive Transcranial Magnetic Stimulation (rTMS) Improves Facial Affect Recognition in Schizophrenia Brain Stimulation Schizophrenia Facial affect recognition Repetitive transcranial magnetic stimulation (rTMS) |
author_facet |
Wolfgang Wölwer Agnes Lowe Jürgen Brinkmeyer Marcus Streit Mareke Habakuck Marcus W. Agelink Arian Mobascher Wolfgang Gaebel Joachim Cordes |
author_sort |
Wolfgang Wölwer |
title |
Repetitive Transcranial Magnetic Stimulation (rTMS) Improves Facial Affect Recognition in Schizophrenia |
title_short |
Repetitive Transcranial Magnetic Stimulation (rTMS) Improves Facial Affect Recognition in Schizophrenia |
title_full |
Repetitive Transcranial Magnetic Stimulation (rTMS) Improves Facial Affect Recognition in Schizophrenia |
title_fullStr |
Repetitive Transcranial Magnetic Stimulation (rTMS) Improves Facial Affect Recognition in Schizophrenia |
title_full_unstemmed |
Repetitive Transcranial Magnetic Stimulation (rTMS) Improves Facial Affect Recognition in Schizophrenia |
title_sort |
repetitive transcranial magnetic stimulation (rtms) improves facial affect recognition in schizophrenia |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2014-07-01 |
description |
Objective: Facial affect recognition, a basic building block of social cognition, is often impaired in schizophrenia. Poor facial affect recognition is closely related to poor functional outcome; however, neither social cognitive impairments nor functional outcome are sufficiently improved by antipsychotic drug treatment alone. Adjunctive repetitive transcranial magnetic stimulation (rTMS) has been shown to enhance cognitive functioning in both healthy individuals and in people with neuropsychiatric disorders and to ameliorate clinical symptoms in psychiatric disorders, but its effects on social cognitive impairments in schizophrenia have not yet been studied. Therefore, we evaluated the effects of sham-controlled rTMS on facial affect recognition in patients with chronic schizophrenia. Method: Inpatients (N = 36) on stable antipsychotic treatment were randomly assigned to double-blind high-frequency (10 Hz) rTMS or sham stimulation for a total of ten sessions over two weeks. In the verum group, each session consisted of 10 000 stimuli (20 trains of 5 s) applied over the left dorsolateral prefrontal cortex at 110% of motor threshold. Facial affect recognition was assessed before (T0) and after (T1) the ten sessions. Results: Facial affect recognition improved significantly more after rTMS (accuracy change: mean = 8.9%, SD = 6.0%) than after sham stimulation (mean = 1.6%, SD = 3.5; Cohen's d = 1.45). There was no correlation with clinical improvement. Conclusion: Our results indicate that prefrontal 10 Hz rTMS stimulation may help to ameliorate impaired facial affect recognition in schizophrenia. |
topic |
Schizophrenia Facial affect recognition Repetitive transcranial magnetic stimulation (rTMS) |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X14001703 |
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