Naturally Abundance Vanillin as Starting Material to Synthesizing 4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one

Naturally Abundance Vanillin as Starting Material to Synthesizing 4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one

Indonesia is the second biggest producer of natural vanillin. Traditionally it was isolated from the bean of vanilla (Vanilla planifolia Andrews). This paper reports on applying vanillin as starting material for synthesizing a biologically important chemical structure 3,4-dihydropyrimidinone. The re...

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Bibliographic Details
Main Authors: Masruri MASRURI, Yuga Adi Pranata
Format: Article
Language:English
Published: University of Brawijaya 2015-12-01
Series:Journal of Pure and Applied Chemistry Research
Subjects:
vanillin
Vanilla planifonia
Biginelli
secondary metabolite
dihydropyrimidinone
Online Access:http://jpacr.ub.ac.id/index.php/jpacr/article/view/216/pdf_2
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spelling doaj-7df1d8bef3da4b3fadbff5266f7d5a802020-11-24T23:12:54ZengUniversity of BrawijayaJournal of Pure and Applied Chemistry Research2302-46902015-12-01438893Naturally Abundance Vanillin as Starting Material to Synthesizing 4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-oneMasruri MASRURI0Yuga Adi Pranata1Brawijaya UniversityBrawijaya UniversityIndonesia is the second biggest producer of natural vanillin. Traditionally it was isolated from the bean of vanilla (Vanilla planifolia Andrews). This paper reports on applying vanillin as starting material for synthesizing a biologically important chemical structure 3,4-dihydropyrimidinone. The reaction was undertaken in one step following multi component reaction (MCR). Products determination was undergone using FTIR and UV-Vis spectrophotometry, and also liquid chromatography-mass spectrometry (LCMS). After purification under flash column chromatography in ethyl acetate-hexane, it was found a white solid of 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one in 67% yield with a few amount of an unreacted vanillin.http://jpacr.ub.ac.id/index.php/jpacr/article/view/216/pdf_2vanillinVanilla planifoniaBiginellisecondary metabolitedihydropyrimidinone
collection DOAJ
language English
format Article
sources DOAJ
author Masruri MASRURI
Yuga Adi Pranata
spellingShingle Masruri MASRURI
Yuga Adi Pranata
Naturally Abundance Vanillin as Starting Material to Synthesizing 4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one
Journal of Pure and Applied Chemistry Research
vanillin
Vanilla planifonia
Biginelli
secondary metabolite
dihydropyrimidinone
author_facet Masruri MASRURI
Yuga Adi Pranata
author_sort Masruri MASRURI
title Naturally Abundance Vanillin as Starting Material to Synthesizing 4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one
title_short Naturally Abundance Vanillin as Starting Material to Synthesizing 4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one
title_full Naturally Abundance Vanillin as Starting Material to Synthesizing 4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one
title_fullStr Naturally Abundance Vanillin as Starting Material to Synthesizing 4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one
title_full_unstemmed Naturally Abundance Vanillin as Starting Material to Synthesizing 4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one
title_sort naturally abundance vanillin as starting material to synthesizing 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1h)-one
publisher University of Brawijaya
series Journal of Pure and Applied Chemistry Research
issn 2302-4690
publishDate 2015-12-01
description Indonesia is the second biggest producer of natural vanillin. Traditionally it was isolated from the bean of vanilla (Vanilla planifolia Andrews). This paper reports on applying vanillin as starting material for synthesizing a biologically important chemical structure 3,4-dihydropyrimidinone. The reaction was undertaken in one step following multi component reaction (MCR). Products determination was undergone using FTIR and UV-Vis spectrophotometry, and also liquid chromatography-mass spectrometry (LCMS). After purification under flash column chromatography in ethyl acetate-hexane, it was found a white solid of 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one in 67% yield with a few amount of an unreacted vanillin.
topic vanillin
Vanilla planifonia
Biginelli
secondary metabolite
dihydropyrimidinone
url http://jpacr.ub.ac.id/index.php/jpacr/article/view/216/pdf_2
work_keys_str_mv AT masrurimasruri naturallyabundancevanillinasstartingmaterialtosynthesizing44hydroxy3methoxyphenyl6methyl34dihydropyrimidin21hone
AT yugaadipranata naturallyabundancevanillinasstartingmaterialtosynthesizing44hydroxy3methoxyphenyl6methyl34dihydropyrimidin21hone
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