The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
Chromosome rearrangements can be a cause of altered oncogene expression in cancer, such as a 3q26 translocation in some acute myeloid leukemias (AML) that leads to overexpression of EVI1. Here the authors engineer this rearrangement in a cell line and show that EVI1 overexpression is a result of ‘en...
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Nature Publishing Group
2021-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25862-3 |
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doaj-7df6196de175464e8b50bb614eba9c972021-10-03T11:50:01ZengNature Publishing GroupNature Communications2041-17232021-09-0112111310.1038/s41467-021-25862-3The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loopsSophie Ottema0Roger Mulet-Lazaro1Claudia Erpelinck-Verschueren2Stanley van Herk3Marije Havermans4Andrea Arricibita Varea5Michael Vermeulen6H. Berna Beverloo7Stefan Gröschel8Torsten Haferlach9Claudia Haferlach10Bas J. Wouters11Eric Bindels12Leonie Smeenk13Ruud Delwel14Department of Hematology, Erasmus MC Cancer InstituteDepartment of Hematology, Erasmus MC Cancer InstituteDepartment of Hematology, Erasmus MC Cancer InstituteDepartment of Hematology, Erasmus MC Cancer InstituteDepartment of Hematology, Erasmus MC Cancer InstituteDepartment of Hematology, Erasmus MC Cancer InstituteDepartment of Hematology, Erasmus MC Cancer InstituteDepartment of Clinical Genetics, Erasmus University Medical CenterA380, German Cancer Research CenterMunich Leukemia LaboratoryMunich Leukemia LaboratoryDepartment of Hematology, Erasmus MC Cancer InstituteDepartment of Hematology, Erasmus MC Cancer InstituteDepartment of Hematology, Erasmus MC Cancer InstituteDepartment of Hematology, Erasmus MC Cancer InstituteChromosome rearrangements can be a cause of altered oncogene expression in cancer, such as a 3q26 translocation in some acute myeloid leukemias (AML) that leads to overexpression of EVI1. Here the authors engineer this rearrangement in a cell line and show that EVI1 overexpression is a result of ‘enhancer hijacking’ of the MYC superenhancer, which is facilitated by CTCF-mediated loops.https://doi.org/10.1038/s41467-021-25862-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sophie Ottema Roger Mulet-Lazaro Claudia Erpelinck-Verschueren Stanley van Herk Marije Havermans Andrea Arricibita Varea Michael Vermeulen H. Berna Beverloo Stefan Gröschel Torsten Haferlach Claudia Haferlach Bas J. Wouters Eric Bindels Leonie Smeenk Ruud Delwel |
| spellingShingle |
Sophie Ottema Roger Mulet-Lazaro Claudia Erpelinck-Verschueren Stanley van Herk Marije Havermans Andrea Arricibita Varea Michael Vermeulen H. Berna Beverloo Stefan Gröschel Torsten Haferlach Claudia Haferlach Bas J. Wouters Eric Bindels Leonie Smeenk Ruud Delwel The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops Nature Communications |
| author_facet |
Sophie Ottema Roger Mulet-Lazaro Claudia Erpelinck-Verschueren Stanley van Herk Marije Havermans Andrea Arricibita Varea Michael Vermeulen H. Berna Beverloo Stefan Gröschel Torsten Haferlach Claudia Haferlach Bas J. Wouters Eric Bindels Leonie Smeenk Ruud Delwel |
| author_sort |
Sophie Ottema |
| title |
The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops |
| title_short |
The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops |
| title_full |
The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops |
| title_fullStr |
The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops |
| title_full_unstemmed |
The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops |
| title_sort |
leukemic oncogene evi1 hijacks a myc super-enhancer by ctcf-facilitated loops |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-09-01 |
| description |
Chromosome rearrangements can be a cause of altered oncogene expression in cancer, such as a 3q26 translocation in some acute myeloid leukemias (AML) that leads to overexpression of EVI1. Here the authors engineer this rearrangement in a cell line and show that EVI1 overexpression is a result of ‘enhancer hijacking’ of the MYC superenhancer, which is facilitated by CTCF-mediated loops. |
| url |
https://doi.org/10.1038/s41467-021-25862-3 |
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