Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (<i>S</i>)-Cetirizine by Lys191 in Human Histamine H<sub>1</sub> Receptors

Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (<i>S</i>)-Cetirizine by Lys191 in Human Histamine H<sub>1</sub> Receptors

Cetirizine is a zwitterionic second-generation antihistamine containing <i>R</i>- and <i>S</i>-enantiomers, levocetirizine, and (<i>S</i>)-cetirizine. Levocetirizine is known to have a higher affinity for the histamine H<sub>1</sub> receptors than (<...

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Bibliographic Details
Main Authors: Shigeru Hishinuma, Yuri Tamura, Chihiro Kobayashi, Chizuru Akatsu, Masaru Shoji
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
affinity
enthalpy
entropy
histamine H<sub>1</sub> receptor
levocetirizine
(<i>S</i>)-cetirizine
Online Access:https://www.mdpi.com/1422-0067/19/12/4067

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