Tremor-specific neuronal oscillation pattern in dorsal subthalamic nucleus of parkinsonian patients
Background: Subthalamic nucleus (STN) deep brain stimulation effectively improves parkinsonian symptoms. It is hypothesized that distinct functional territories with different neurophysiologic activity within the STN relate to different symptoms. Objective: The aim of the study was to identify disti...
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doaj-7e1511da2d6e413d9cc14bdc78a30a332021-03-18T04:35:19ZengElsevierBrain Stimulation1935-861X2012-07-0153305314Tremor-specific neuronal oscillation pattern in dorsal subthalamic nucleus of parkinsonian patientsMaria Fiorella Contarino0Lo J. Bour1Maarten Bot2Pepijn van den Munckhof3Johannes D. Speelman4Peter Richard Schuurman5Rob M. de Bie6Department of Neurology/Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands; Correspondence: Maria Fiorella Contarino, Department of Neurology/Clinical Neurophysiology Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.Department of Neurology/Clinical Neurophysiology, Academic Medical Center, Amsterdam, The NetherlandsDepartment of Neurology/Clinical Neurophysiology, Academic Medical Center, Amsterdam, The NetherlandsDepartment of Neurosurgery, Academic Medical Center, Amsterdam, The NetherlandsDepartment of Neurology/Clinical Neurophysiology, Academic Medical Center, Amsterdam, The NetherlandsDepartment of Neurosurgery, Academic Medical Center, Amsterdam, The NetherlandsDepartment of Neurology/Clinical Neurophysiology, Academic Medical Center, Amsterdam, The NetherlandsBackground: Subthalamic nucleus (STN) deep brain stimulation effectively improves parkinsonian symptoms. It is hypothesized that distinct functional territories with different neurophysiologic activity within the STN relate to different symptoms. Objective: The aim of the study was to identify distinctive characteristics of STN neuronal activity related to tremor by directly comparing tremor sides with no-tremor sides. In addition, we studied the spatial pattern of frequency distributions within the STN in more detail. Methods: We analyzed intraoperative STN single/multiunit recordings from 33 tremor sides and 23 no-tremor sides. STN tracks were normalized to a length of 1 and subdivided into eight successive layers. The power spectral density was split into six frequency bands: theta (3-8 Hz), alpha (9-12 Hz), lower beta (13-20 Hz), upper beta (21-30 Hz), lower gamma (31-59 Hz), and upper gamma (60-100 Hz). Results: Tremor sides presented predominant theta frequency oscillations in the most dorsal layers of the STN, whereas in no-tremor sides beta frequencies predominated. Oscillatory activity was stronger in the dorsal STN than in the ventral, and this pattern was specific for frequencies in the theta, alpha, and beta bands, but not in the gamma bands. Conclusions: Our study supports the hypothesis that the presence of tremor is associated with a distinctive neuronal oscillations pattern. In particular, we demonstrate the specificity of the association of theta frequencies in the dorsal STN with tremor. Identification of symptom-specific characteristics of intraoperative microrecordings in the STN may lead to refinement of targeting for each patient, tailored to the specific clinical presentation.http://www.sciencedirect.com/science/article/pii/S1935861X11000568Parkinson’s diseasedeep brain stimulationtremormicroelectrode recordingsbasal ganglia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Fiorella Contarino Lo J. Bour Maarten Bot Pepijn van den Munckhof Johannes D. Speelman Peter Richard Schuurman Rob M. de Bie |
spellingShingle |
Maria Fiorella Contarino Lo J. Bour Maarten Bot Pepijn van den Munckhof Johannes D. Speelman Peter Richard Schuurman Rob M. de Bie Tremor-specific neuronal oscillation pattern in dorsal subthalamic nucleus of parkinsonian patients Brain Stimulation Parkinson’s disease deep brain stimulation tremor microelectrode recordings basal ganglia |
author_facet |
Maria Fiorella Contarino Lo J. Bour Maarten Bot Pepijn van den Munckhof Johannes D. Speelman Peter Richard Schuurman Rob M. de Bie |
author_sort |
Maria Fiorella Contarino |
title |
Tremor-specific neuronal oscillation pattern in dorsal subthalamic nucleus of parkinsonian patients |
title_short |
Tremor-specific neuronal oscillation pattern in dorsal subthalamic nucleus of parkinsonian patients |
title_full |
Tremor-specific neuronal oscillation pattern in dorsal subthalamic nucleus of parkinsonian patients |
title_fullStr |
Tremor-specific neuronal oscillation pattern in dorsal subthalamic nucleus of parkinsonian patients |
title_full_unstemmed |
Tremor-specific neuronal oscillation pattern in dorsal subthalamic nucleus of parkinsonian patients |
title_sort |
tremor-specific neuronal oscillation pattern in dorsal subthalamic nucleus of parkinsonian patients |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2012-07-01 |
description |
Background: Subthalamic nucleus (STN) deep brain stimulation effectively improves parkinsonian symptoms. It is hypothesized that distinct functional territories with different neurophysiologic activity within the STN relate to different symptoms. Objective: The aim of the study was to identify distinctive characteristics of STN neuronal activity related to tremor by directly comparing tremor sides with no-tremor sides. In addition, we studied the spatial pattern of frequency distributions within the STN in more detail. Methods: We analyzed intraoperative STN single/multiunit recordings from 33 tremor sides and 23 no-tremor sides. STN tracks were normalized to a length of 1 and subdivided into eight successive layers. The power spectral density was split into six frequency bands: theta (3-8 Hz), alpha (9-12 Hz), lower beta (13-20 Hz), upper beta (21-30 Hz), lower gamma (31-59 Hz), and upper gamma (60-100 Hz). Results: Tremor sides presented predominant theta frequency oscillations in the most dorsal layers of the STN, whereas in no-tremor sides beta frequencies predominated. Oscillatory activity was stronger in the dorsal STN than in the ventral, and this pattern was specific for frequencies in the theta, alpha, and beta bands, but not in the gamma bands. Conclusions: Our study supports the hypothesis that the presence of tremor is associated with a distinctive neuronal oscillations pattern. In particular, we demonstrate the specificity of the association of theta frequencies in the dorsal STN with tremor. Identification of symptom-specific characteristics of intraoperative microrecordings in the STN may lead to refinement of targeting for each patient, tailored to the specific clinical presentation. |
topic |
Parkinson’s disease deep brain stimulation tremor microelectrode recordings basal ganglia |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X11000568 |
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