The Use of Testicular Sperm for Intracytoplasmic Sperm Injection in Patients with High Sperm DNA Damage: A Systematic Review

The Use of Testicular Sperm for Intracytoplasmic Sperm Injection in Patients with High Sperm DNA Damage: A Systematic Review

The advent of intracytoplasmic sperm injection (ICSI) has changed the human reproduction landscape by overcoming several limitations related to both male and female infertility factors. However, despite the development of new technologies, the live-birth rate with ICSI has not exceeded 30%. In order...

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Bibliographic Details
Main Authors: Rafael F. Ambar, Ashok Agarwal, Ahmad Majzoub, Sarah Vij, Nicholas N. Tadros, Chak-Lam Cho, Neel Parekh, Edson Borges Jr., Sidney Glina
Format: Article
Language:English
Published: Korean Society for Sexual Medicine and Andrology 2021-07-01
Series:The World Journal of Men's Health
Subjects:
dna damage
dna fragmentation
infertility
male
sperm retrieval
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spelling doaj-7e16733376674bfea81bf5105fb7fd932021-06-21T01:09:10ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902021-07-0139339139810.5534/wjmh.200084The Use of Testicular Sperm for Intracytoplasmic Sperm Injection in Patients with High Sperm DNA Damage: A Systematic ReviewRafael F. Ambar0https://orcid.org/0000-0002-3496-2895Ashok Agarwal1https://orcid.org/0000-0003-0585-1026Ahmad Majzoub2https://orcid.org/0000-0001-7423-6241Sarah Vij3https://orcid.org/0000-0001-8282-2339Nicholas N. Tadros4https://orcid.org/0000-0002-2272-235XChak-Lam Cho5https://orcid.org/0000-0003-2520-6833Neel Parekh6https://orcid.org/0000-0002-6218-9254Edson Borges Jr.7https://orcid.org/0000-0002-4971-1925Sidney Glina8https://orcid.org/0000-0002-9053-5046Cleveland Clinic, Cleveland, OH, USACleveland Clinic, Cleveland, OH, USACleveland Clinic, Cleveland, OH, USACleveland Clinic, Cleveland, OH, USASouthern Illinois University, Springfield, IL, USAUnion Hospital, Hong KongCleveland Clinic, Cleveland, OH, USASapientiae Institute, São PauloCentro Universitario em Saude do ABC, Santo André, BrazilThe advent of intracytoplasmic sperm injection (ICSI) has changed the human reproduction landscape by overcoming several limitations related to both male and female infertility factors. However, despite the development of new technologies, the live-birth rate with ICSI has not exceeded 30%. In order to improve assisted reproductive technology outcomes, advanced sperm function analysis have gained increased attention and the effects of sperm DNA fragmentation (SDF) on assisted repro-duction success are being extensively studied. Utilizing ejaculated sperm with an elevated SDF has been found to result in poor ICSI outcomes. Furthermore, studies have reported that testicular sperm has lower SDF level, when compared to ejacu-lated sperm. This has led a number of clinicians world-wide to offer testicular sperm retrieval for ICSI in non-azoospermic males with high SDF. This practice has remained controversial due to lack of high quality evidence.dna damagedna fragmentationinfertilitymalesperm retrieval
collection DOAJ
language English
format Article
sources DOAJ
author Rafael F. Ambar
Ashok Agarwal
Ahmad Majzoub
Sarah Vij
Nicholas N. Tadros
Chak-Lam Cho
Neel Parekh
Edson Borges Jr.
Sidney Glina
spellingShingle Rafael F. Ambar
Ashok Agarwal
Ahmad Majzoub
Sarah Vij
Nicholas N. Tadros
Chak-Lam Cho
Neel Parekh
Edson Borges Jr.
Sidney Glina
The Use of Testicular Sperm for Intracytoplasmic Sperm Injection in Patients with High Sperm DNA Damage: A Systematic Review
The World Journal of Men's Health
dna damage
dna fragmentation
infertility
male
sperm retrieval
author_facet Rafael F. Ambar
Ashok Agarwal
Ahmad Majzoub
Sarah Vij
Nicholas N. Tadros
Chak-Lam Cho
Neel Parekh
Edson Borges Jr.
Sidney Glina
author_sort Rafael F. Ambar
title The Use of Testicular Sperm for Intracytoplasmic Sperm Injection in Patients with High Sperm DNA Damage: A Systematic Review
title_short The Use of Testicular Sperm for Intracytoplasmic Sperm Injection in Patients with High Sperm DNA Damage: A Systematic Review
title_full The Use of Testicular Sperm for Intracytoplasmic Sperm Injection in Patients with High Sperm DNA Damage: A Systematic Review
title_fullStr The Use of Testicular Sperm for Intracytoplasmic Sperm Injection in Patients with High Sperm DNA Damage: A Systematic Review
title_full_unstemmed The Use of Testicular Sperm for Intracytoplasmic Sperm Injection in Patients with High Sperm DNA Damage: A Systematic Review
title_sort use of testicular sperm for intracytoplasmic sperm injection in patients with high sperm dna damage: a systematic review
publisher Korean Society for Sexual Medicine and Andrology
series The World Journal of Men's Health
issn 2287-4208
2287-4690
publishDate 2021-07-01
description The advent of intracytoplasmic sperm injection (ICSI) has changed the human reproduction landscape by overcoming several limitations related to both male and female infertility factors. However, despite the development of new technologies, the live-birth rate with ICSI has not exceeded 30%. In order to improve assisted reproductive technology outcomes, advanced sperm function analysis have gained increased attention and the effects of sperm DNA fragmentation (SDF) on assisted repro-duction success are being extensively studied. Utilizing ejaculated sperm with an elevated SDF has been found to result in poor ICSI outcomes. Furthermore, studies have reported that testicular sperm has lower SDF level, when compared to ejacu-lated sperm. This has led a number of clinicians world-wide to offer testicular sperm retrieval for ICSI in non-azoospermic males with high SDF. This practice has remained controversial due to lack of high quality evidence.
topic dna damage
dna fragmentation
infertility
male
sperm retrieval
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