A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis.
Approximately 9% of cancer-related deaths are caused by colorectal cancer. Liver metastasis is a major factor for the high colorectal cancer mortality rate. However, the molecular mechanism underlying colorectal cancer liver metastasis remains unclear. Using a global and multidimensional integration...
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doaj-7e294e402357470d8d50962c09f0e4ed2020-11-24T21:48:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01126e017876010.1371/journal.pone.0178760A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis.Bo GaoTian YuDongbo XueBoshi SunQin ShaoHani ChoudhryVictoria MarcusJiannis RagoussisYuguo ZhangWeihui ZhangZu-Hua GaoApproximately 9% of cancer-related deaths are caused by colorectal cancer. Liver metastasis is a major factor for the high colorectal cancer mortality rate. However, the molecular mechanism underlying colorectal cancer liver metastasis remains unclear. Using a global and multidimensional integration approach, we studied sequencing data, protein-protein interactions, and regulation of transcription factor and non-coding RNAs in primary tumor samples and liver metastasis samples to unveil the potential bridging molecules and the regulators that functionally link different stages of colorectal cancer liver metastasis. Primary tumor samples and liver metastasis samples had modules with significant overlap and crosstalk from which we identified several bridging genes (e.g. KNG1 and COX5B), transcription factors (e.g. E2F4 and CDX2), microRNAs (e.g. miR-590-3p and miR-203) and lncRNAs (e.g. lincIRX5 and lincFOXF1) that may play an important role in the process of colorectal cancer liver metastasis. This study enhances our understanding of the genetic alterations and transcriptional regulation that drive the metastatic process, but also provides the methodology to guide the studies on other metastatic cancers.http://europepmc.org/articles/PMC5476238?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bo Gao Tian Yu Dongbo Xue Boshi Sun Qin Shao Hani Choudhry Victoria Marcus Jiannis Ragoussis Yuguo Zhang Weihui Zhang Zu-Hua Gao |
spellingShingle |
Bo Gao Tian Yu Dongbo Xue Boshi Sun Qin Shao Hani Choudhry Victoria Marcus Jiannis Ragoussis Yuguo Zhang Weihui Zhang Zu-Hua Gao A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis. PLoS ONE |
author_facet |
Bo Gao Tian Yu Dongbo Xue Boshi Sun Qin Shao Hani Choudhry Victoria Marcus Jiannis Ragoussis Yuguo Zhang Weihui Zhang Zu-Hua Gao |
author_sort |
Bo Gao |
title |
A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis. |
title_short |
A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis. |
title_full |
A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis. |
title_fullStr |
A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis. |
title_full_unstemmed |
A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis. |
title_sort |
multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
Approximately 9% of cancer-related deaths are caused by colorectal cancer. Liver metastasis is a major factor for the high colorectal cancer mortality rate. However, the molecular mechanism underlying colorectal cancer liver metastasis remains unclear. Using a global and multidimensional integration approach, we studied sequencing data, protein-protein interactions, and regulation of transcription factor and non-coding RNAs in primary tumor samples and liver metastasis samples to unveil the potential bridging molecules and the regulators that functionally link different stages of colorectal cancer liver metastasis. Primary tumor samples and liver metastasis samples had modules with significant overlap and crosstalk from which we identified several bridging genes (e.g. KNG1 and COX5B), transcription factors (e.g. E2F4 and CDX2), microRNAs (e.g. miR-590-3p and miR-203) and lncRNAs (e.g. lincIRX5 and lincFOXF1) that may play an important role in the process of colorectal cancer liver metastasis. This study enhances our understanding of the genetic alterations and transcriptional regulation that drive the metastatic process, but also provides the methodology to guide the studies on other metastatic cancers. |
url |
http://europepmc.org/articles/PMC5476238?pdf=render |
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