Potassium Dichromate Impact on Male Reproductive Integrity Biomarker in Rat. Two Generation Study
The aim of this study was the evaluation of Cr VI cumulative and differentiate exposure on integrity biomarker of male reproductive system. The objective was evaluation of potassium dichromate intake on genital organs and sexual accessory glands architecture in male rats from two generation. Males a...
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Agroprint Timisoara
2010-05-01
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doaj-7e2ea9de12f442d3aa1615261bd27fb32020-11-25T03:59:43ZengAgroprint TimisoaraScientific Papers Animal Science and Biotechnologies1841-93642344-45762010-05-01431224229687Potassium Dichromate Impact on Male Reproductive Integrity Biomarker in Rat. Two Generation StudyJelena Rankov0Alexandra Trif1Diana Brezovan2Florin Muselin3Faculty of Veterinary Medicine,TimisoaraFaculty of Veterinary Medicine,TimisoaraFaculty of Veterinary Medicine,TimisoaraFaculty of Veterinary Medicine,TimisoaraThe aim of this study was the evaluation of Cr VI cumulative and differentiate exposure on integrity biomarker of male reproductive system. The objective was evaluation of potassium dichromate intake on genital organs and sexual accessory glands architecture in male rats from two generation. Males and females from F0 generation were exposed to potassium dichromate three months before mating. F1 generation was represented by male pups, resulted from F0 generation, exposed to potassium dichromate in utero, during suckling (via milk and water) period and until sexual maturity. All the animals were divided in one control and three experimental groups, exposed to Cr VI trough drinking water, as followed E1: 25 ppm (LOAEL); E2: 50 ppm: E3: 75 ppm; control group received tap water without chromium content. The experiment was carried out with respecting legislation regarding ethics in animal experiments. The study revealed the presence of congestive and degenerative lesions in genital organs and sexual accessory glands of exposed individuals from F0 and F1 generation such as: interstitial edema, epithelial necrosis and atrophy, membrane exfoliation and necrosis. The lesions frequency and intensity were directly correlated to exposure level, the most affected being E3 group and generation, more pronounced in F1 generation.http://spasb.ro/index.php/spasb/article/view/764chromium vihistoarchitecturemalerattoxicity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jelena Rankov Alexandra Trif Diana Brezovan Florin Muselin |
spellingShingle |
Jelena Rankov Alexandra Trif Diana Brezovan Florin Muselin Potassium Dichromate Impact on Male Reproductive Integrity Biomarker in Rat. Two Generation Study Scientific Papers Animal Science and Biotechnologies chromium vi histoarchitecture male rat toxicity |
author_facet |
Jelena Rankov Alexandra Trif Diana Brezovan Florin Muselin |
author_sort |
Jelena Rankov |
title |
Potassium Dichromate Impact on Male Reproductive Integrity Biomarker in Rat. Two Generation Study |
title_short |
Potassium Dichromate Impact on Male Reproductive Integrity Biomarker in Rat. Two Generation Study |
title_full |
Potassium Dichromate Impact on Male Reproductive Integrity Biomarker in Rat. Two Generation Study |
title_fullStr |
Potassium Dichromate Impact on Male Reproductive Integrity Biomarker in Rat. Two Generation Study |
title_full_unstemmed |
Potassium Dichromate Impact on Male Reproductive Integrity Biomarker in Rat. Two Generation Study |
title_sort |
potassium dichromate impact on male reproductive integrity biomarker in rat. two generation study |
publisher |
Agroprint Timisoara |
series |
Scientific Papers Animal Science and Biotechnologies |
issn |
1841-9364 2344-4576 |
publishDate |
2010-05-01 |
description |
The aim of this study was the evaluation of Cr VI cumulative and differentiate exposure on integrity biomarker of male reproductive system. The objective was evaluation of potassium dichromate intake on genital organs and sexual accessory glands architecture in male rats from two generation. Males and females from F0 generation were exposed to potassium dichromate three months before mating. F1 generation was represented by male pups, resulted from F0 generation, exposed to potassium dichromate in utero, during suckling (via milk and water) period and until sexual maturity. All the animals were divided in one control and three experimental groups, exposed to Cr VI trough drinking water, as followed E1: 25 ppm (LOAEL); E2: 50 ppm: E3: 75 ppm; control group received tap water without chromium content. The experiment was carried out with respecting legislation regarding ethics in animal experiments. The study revealed the presence of congestive and degenerative lesions in genital organs and sexual accessory glands of exposed individuals from F0 and F1 generation such as: interstitial edema, epithelial necrosis and atrophy, membrane exfoliation and necrosis. The lesions frequency and intensity were directly correlated to exposure level, the most affected being E3 group and generation, more pronounced in F1 generation. |
topic |
chromium vi histoarchitecture male rat toxicity |
url |
http://spasb.ro/index.php/spasb/article/view/764 |
work_keys_str_mv |
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