Effect of adjuvant low-molecular-weight heparin therapy on placental hypoxia and cell apoptosis in puerperae with severe preeclampsia
Objective: To study the effect of adjuvant low-molecular-weight heparin therapy on placental hypoxia and cell apoptosis in puerperae with severe preeclampsia. Methods: A total of 94 puerperae with severe preeclampsia who received treatment and safely gave birth in our hospital between May 2014 an...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2017-04-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201708/21.pdf |
Summary: | Objective: To study the effect of adjuvant low-molecular-weight heparin therapy on placental
hypoxia and cell apoptosis in puerperae with severe preeclampsia. Methods: A total of 94
puerperae with severe preeclampsia who received treatment and safely gave birth in our
hospital between May 2014 and May 2016 were selected as the research subjects and randomly
divided into the LMWH group who received low-molecular-weight heparin combined
with conventional symptomatic treatment and the control group who received conventional
symptomatic treatment. Before and after treatment, serum was collected respectively to
determine the levels of placental hypoxia-related cytokines, and after delivery, the placentas
were collected to detect oxidative stress indexes and cell apoptosis indexes. Results: After
treatment, serum PLGF and PAPP-A levels of both groups were significantly higher than
those before treatment while sFlt-1 and sEng levels were significantly lower than those
before treatment, and after treatment, serum PLGF and PAPP-A levels of LMWH group were
significantly higher than those of control group while sFlt-1 and sEng levels were significantly
lower than those of control group; ROS and RNS levels as well as Fas, FasL, caspase-3 and
caspase-8 protein expression in placenta tissue of LMWH group were significantly lower than
those of control group while GPx-1, SOD-1 and Trx levels as well as Survivin, XIAP and
Bcl-2 protein expression were significantly higher than those of control group. Conclusion:
Adjuvant low-molecular-weight heparin therapy can relieve the placental hypoxia, improve
oxidative stress reaction and inhibit cell apoptosis in puerperae with severe preeclampsia. |
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ISSN: | 1007-1237 1007-1237 |