Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index
Macroscopic deposition of epicardial adipose tissue (EAT) has been strongly associated with numerous indices of obesity and cardiovascular disease risk. In contrast, the morphology of EAT adipocytes has rarely been investigated. We aimed to determine whether obesity-driven adipocyte hypertrophy, whi...
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doaj-7e3927f9c07f44a4958340c0cb3ce23e2020-11-25T02:12:30ZengTaylor & Francis GroupAdipocyte2162-39452162-397X2019-01-018141242010.1080/21623945.2019.17013871701387Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass indexHamish M. Aitken-Buck0Mohammed Moharram1Aram A Babakr2Robin Reijers3Isabelle Van Hout4Ingrid C. Fomison-Nurse5Ramanen Sugunesegran6Krishna Bhagwat7Phillip J Davis8Richard W. Bunton9Michael J. A. Williams10Martin K. Stiles11Peter P. Jones12Sean Coffey13Regis R. Lamberts14University of OtagoDunedin HospitalUniversity of OtagoUniversity of OtagoUniversity of OtagoUniversity of OtagoDunedin HospitalDunedin HospitalDunedin HospitalDunedin HospitalDunedin HospitalWaikato District Health BoardUniversity of OtagoDunedin HospitalUniversity of OtagoMacroscopic deposition of epicardial adipose tissue (EAT) has been strongly associated with numerous indices of obesity and cardiovascular disease risk. In contrast, the morphology of EAT adipocytes has rarely been investigated. We aimed to determine whether obesity-driven adipocyte hypertrophy, which is characteristic of other visceral fat depots, is found within EAT adipocytes. EAT samples were collected from cardiac surgery patients (n = 49), stained with haematoxylin & eosin, and analysed for mean adipocyte size and non-adipocyte area. EAT thickness was measured using echocardiography. A significant positive relationship was found between EAT thickness and body mass index (BMI). When stratified into standardized BMI categories, EAT thickness was 58.7% greater (p = 0.003) in patients from the obese (7.3 ± 1.8 mm) compared to normal (4.6 ± 0.9 mm) category. BMI as a continuous variable significantly correlated with EAT thickness (r = 0.56, p < 0.0001). Conversely, no correlation was observed between adipocyte size and either BMI or EAT thickness. No difference in the non-adipocyte area was found between BMI groups. Our results suggest that the increased macroscopic EAT deposition associated with obesity is not caused by adipocyte hypertrophy. Rather, alternative remodelling via adipocyte proliferation might be responsible for the observed EAT expansion.http://dx.doi.org/10.1080/21623945.2019.1701387epicardial adipose tissueadipocytesbody mass indexobesityadipocyte remodelling |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hamish M. Aitken-Buck Mohammed Moharram Aram A Babakr Robin Reijers Isabelle Van Hout Ingrid C. Fomison-Nurse Ramanen Sugunesegran Krishna Bhagwat Phillip J Davis Richard W. Bunton Michael J. A. Williams Martin K. Stiles Peter P. Jones Sean Coffey Regis R. Lamberts |
spellingShingle |
Hamish M. Aitken-Buck Mohammed Moharram Aram A Babakr Robin Reijers Isabelle Van Hout Ingrid C. Fomison-Nurse Ramanen Sugunesegran Krishna Bhagwat Phillip J Davis Richard W. Bunton Michael J. A. Williams Martin K. Stiles Peter P. Jones Sean Coffey Regis R. Lamberts Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index Adipocyte epicardial adipose tissue adipocytes body mass index obesity adipocyte remodelling |
author_facet |
Hamish M. Aitken-Buck Mohammed Moharram Aram A Babakr Robin Reijers Isabelle Van Hout Ingrid C. Fomison-Nurse Ramanen Sugunesegran Krishna Bhagwat Phillip J Davis Richard W. Bunton Michael J. A. Williams Martin K. Stiles Peter P. Jones Sean Coffey Regis R. Lamberts |
author_sort |
Hamish M. Aitken-Buck |
title |
Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index |
title_short |
Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index |
title_full |
Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index |
title_fullStr |
Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index |
title_full_unstemmed |
Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index |
title_sort |
relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index |
publisher |
Taylor & Francis Group |
series |
Adipocyte |
issn |
2162-3945 2162-397X |
publishDate |
2019-01-01 |
description |
Macroscopic deposition of epicardial adipose tissue (EAT) has been strongly associated with numerous indices of obesity and cardiovascular disease risk. In contrast, the morphology of EAT adipocytes has rarely been investigated. We aimed to determine whether obesity-driven adipocyte hypertrophy, which is characteristic of other visceral fat depots, is found within EAT adipocytes. EAT samples were collected from cardiac surgery patients (n = 49), stained with haematoxylin & eosin, and analysed for mean adipocyte size and non-adipocyte area. EAT thickness was measured using echocardiography. A significant positive relationship was found between EAT thickness and body mass index (BMI). When stratified into standardized BMI categories, EAT thickness was 58.7% greater (p = 0.003) in patients from the obese (7.3 ± 1.8 mm) compared to normal (4.6 ± 0.9 mm) category. BMI as a continuous variable significantly correlated with EAT thickness (r = 0.56, p < 0.0001). Conversely, no correlation was observed between adipocyte size and either BMI or EAT thickness. No difference in the non-adipocyte area was found between BMI groups. Our results suggest that the increased macroscopic EAT deposition associated with obesity is not caused by adipocyte hypertrophy. Rather, alternative remodelling via adipocyte proliferation might be responsible for the observed EAT expansion. |
topic |
epicardial adipose tissue adipocytes body mass index obesity adipocyte remodelling |
url |
http://dx.doi.org/10.1080/21623945.2019.1701387 |
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