Increased Lytic Efficiency of Bovine Macrophages Trained with Killed Mycobacteria.
Innate immunity is evolutionarily conserved in multicellular organisms and was considered to lack memory until very recently. One of its more characteristic mechanisms is phagocytosis, the ability of cells to engulf, process and eventually destroy any injuring agent. We report the results of an ex v...
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doaj-7e437dc3aac9465bb2bffb8cb8ecfe092020-11-25T02:27:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011111e016560710.1371/journal.pone.0165607Increased Lytic Efficiency of Bovine Macrophages Trained with Killed Mycobacteria.Ramon A JusteMarta Alonso-HearnJoseba M GarridoNaiara AbendañoIker A SevillaChristian GortazarJosé de la FuenteLucas DominguezInnate immunity is evolutionarily conserved in multicellular organisms and was considered to lack memory until very recently. One of its more characteristic mechanisms is phagocytosis, the ability of cells to engulf, process and eventually destroy any injuring agent. We report the results of an ex vivo experiment in bovine macrophages in which improved clearance of Mycobacterium bovis (M. bovis) was induced by pre-exposure to a heat killed M. bovis preparation. The effects were independent of humoral and cellular adaptive immune responses and lasted up to six months. Specifically, our results demonstrate the existence of a training effect in the lytic phase of phagocytosis that can be activated by killed mycobacteria, thus suggesting a new mechanism of vaccine protection. These findings are compatible with the recently proposed concept of trained immunity, which was developed to explain the observation that innate immune responses provide unspecific protection against pathogens including other than those that originally triggered the immune response.http://europepmc.org/articles/PMC5098821?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ramon A Juste Marta Alonso-Hearn Joseba M Garrido Naiara Abendaño Iker A Sevilla Christian Gortazar José de la Fuente Lucas Dominguez |
spellingShingle |
Ramon A Juste Marta Alonso-Hearn Joseba M Garrido Naiara Abendaño Iker A Sevilla Christian Gortazar José de la Fuente Lucas Dominguez Increased Lytic Efficiency of Bovine Macrophages Trained with Killed Mycobacteria. PLoS ONE |
author_facet |
Ramon A Juste Marta Alonso-Hearn Joseba M Garrido Naiara Abendaño Iker A Sevilla Christian Gortazar José de la Fuente Lucas Dominguez |
author_sort |
Ramon A Juste |
title |
Increased Lytic Efficiency of Bovine Macrophages Trained with Killed Mycobacteria. |
title_short |
Increased Lytic Efficiency of Bovine Macrophages Trained with Killed Mycobacteria. |
title_full |
Increased Lytic Efficiency of Bovine Macrophages Trained with Killed Mycobacteria. |
title_fullStr |
Increased Lytic Efficiency of Bovine Macrophages Trained with Killed Mycobacteria. |
title_full_unstemmed |
Increased Lytic Efficiency of Bovine Macrophages Trained with Killed Mycobacteria. |
title_sort |
increased lytic efficiency of bovine macrophages trained with killed mycobacteria. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
Innate immunity is evolutionarily conserved in multicellular organisms and was considered to lack memory until very recently. One of its more characteristic mechanisms is phagocytosis, the ability of cells to engulf, process and eventually destroy any injuring agent. We report the results of an ex vivo experiment in bovine macrophages in which improved clearance of Mycobacterium bovis (M. bovis) was induced by pre-exposure to a heat killed M. bovis preparation. The effects were independent of humoral and cellular adaptive immune responses and lasted up to six months. Specifically, our results demonstrate the existence of a training effect in the lytic phase of phagocytosis that can be activated by killed mycobacteria, thus suggesting a new mechanism of vaccine protection. These findings are compatible with the recently proposed concept of trained immunity, which was developed to explain the observation that innate immune responses provide unspecific protection against pathogens including other than those that originally triggered the immune response. |
url |
http://europepmc.org/articles/PMC5098821?pdf=render |
work_keys_str_mv |
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