Sitagliptin alleviated myocardial remodeling of the left ventricle and improved cardiac diastolic dysfunction in diabetic rats

Sitagliptin alleviated myocardial remodeling of the left ventricle and improved cardiac diastolic dysfunction in diabetic rats

Objective: Sitagliptin, a dipeptidyl peptidase IV (DPP-Ⅳ) inhibitor, has a biological role in improving the serum levels of glucagon-like peptide 1 (GLP-1). Hence, we sought to determine the effect of sitagliptin on myocardial inflammation, collagen metabolism, lipid content and myocardial apoptosis...

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Bibliographic Details
Main Authors: Yu-Sheng Liu, Zhi-Wei Huang, Lin Wang, Xin-Xin Liu, Yong-Mei Wang, Yun Zhang, Mei Zhang
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Journal of Pharmacological Sciences
Subjects:
Diabetes mellitus
Sitagliptin
Myocardial remodeling
Cardiac function
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861314000280

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