Tracking the early depleting transmission dynamics of COVID-19 with a time-varying SIR model
Abstract The susceptible-infectious-removed (SIR) model offers the simplest framework to study transmission dynamics of COVID-19, however, it does not factor in its early depleting trend observed during a lockdown. We modified the SIR model to specifically simulate the early depleting transmission d...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-12-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-78739-8 |
id |
doaj-7e4b66cf9c174a618a17437128f93686 |
---|---|
record_format |
Article |
spelling |
doaj-7e4b66cf9c174a618a17437128f936862020-12-13T12:33:20ZengNature Publishing GroupScientific Reports2045-23222020-12-0110111110.1038/s41598-020-78739-8Tracking the early depleting transmission dynamics of COVID-19 with a time-varying SIR modelKian Boon Law0Kalaiarasu M. Peariasamy1Balvinder Singh Gill2Sarbhan Singh3Bala Murali Sundram4Kamesh Rajendran5Sarat Chandra Dass6Yi Lin Lee7Pik Pin Goh8Hishamshah Ibrahim9Noor Hisham Abdullah10Institute for Clinical Research, Ministry of Health MalaysiaInstitute for Clinical Research, Ministry of Health MalaysiaInstitute for Medical Research, Ministry of Health MalaysiaInstitute for Medical Research, Ministry of Health MalaysiaInstitute for Medical Research, Ministry of Health MalaysiaInstitute for Medical Research, Ministry of Health MalaysiaHeriot-Watt University MalaysiaInstitute for Clinical Research, Ministry of Health MalaysiaInstitute for Clinical Research, Ministry of Health MalaysiaMinistry of Health MalaysiaMinistry of Health MalaysiaAbstract The susceptible-infectious-removed (SIR) model offers the simplest framework to study transmission dynamics of COVID-19, however, it does not factor in its early depleting trend observed during a lockdown. We modified the SIR model to specifically simulate the early depleting transmission dynamics of COVID-19 to better predict its temporal trend in Malaysia. The classical SIR model was fitted to observed total (I total), active (I) and removed (R) cases of COVID-19 before lockdown to estimate the basic reproduction number. Next, the model was modified with a partial time-varying force of infection, given by a proportionally depleting transmission coefficient, $$\beta_{t}$$ β t and a fractional term, z. The modified SIR model was then fitted to observed data over 6 weeks during the lockdown. Model fitting and projection were validated using the mean absolute percent error (MAPE). The transmission dynamics of COVID-19 was interrupted immediately by the lockdown. The modified SIR model projected the depleting temporal trends with lowest MAPE for I total, followed by I, I daily and R. During lockdown, the dynamics of COVID-19 depleted at a rate of 4.7% each day with a decreased capacity of 40%. For 7-day and 14-day projections, the modified SIR model accurately predicted I total, I and R. The depleting transmission dynamics for COVID-19 during lockdown can be accurately captured by time-varying SIR model. Projection generated based on observed data is useful for future planning and control of COVID-19.https://doi.org/10.1038/s41598-020-78739-8 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kian Boon Law Kalaiarasu M. Peariasamy Balvinder Singh Gill Sarbhan Singh Bala Murali Sundram Kamesh Rajendran Sarat Chandra Dass Yi Lin Lee Pik Pin Goh Hishamshah Ibrahim Noor Hisham Abdullah |
spellingShingle |
Kian Boon Law Kalaiarasu M. Peariasamy Balvinder Singh Gill Sarbhan Singh Bala Murali Sundram Kamesh Rajendran Sarat Chandra Dass Yi Lin Lee Pik Pin Goh Hishamshah Ibrahim Noor Hisham Abdullah Tracking the early depleting transmission dynamics of COVID-19 with a time-varying SIR model Scientific Reports |
author_facet |
Kian Boon Law Kalaiarasu M. Peariasamy Balvinder Singh Gill Sarbhan Singh Bala Murali Sundram Kamesh Rajendran Sarat Chandra Dass Yi Lin Lee Pik Pin Goh Hishamshah Ibrahim Noor Hisham Abdullah |
author_sort |
Kian Boon Law |
title |
Tracking the early depleting transmission dynamics of COVID-19 with a time-varying SIR model |
title_short |
Tracking the early depleting transmission dynamics of COVID-19 with a time-varying SIR model |
title_full |
Tracking the early depleting transmission dynamics of COVID-19 with a time-varying SIR model |
title_fullStr |
Tracking the early depleting transmission dynamics of COVID-19 with a time-varying SIR model |
title_full_unstemmed |
Tracking the early depleting transmission dynamics of COVID-19 with a time-varying SIR model |
title_sort |
tracking the early depleting transmission dynamics of covid-19 with a time-varying sir model |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2020-12-01 |
description |
Abstract The susceptible-infectious-removed (SIR) model offers the simplest framework to study transmission dynamics of COVID-19, however, it does not factor in its early depleting trend observed during a lockdown. We modified the SIR model to specifically simulate the early depleting transmission dynamics of COVID-19 to better predict its temporal trend in Malaysia. The classical SIR model was fitted to observed total (I total), active (I) and removed (R) cases of COVID-19 before lockdown to estimate the basic reproduction number. Next, the model was modified with a partial time-varying force of infection, given by a proportionally depleting transmission coefficient, $$\beta_{t}$$ β t and a fractional term, z. The modified SIR model was then fitted to observed data over 6 weeks during the lockdown. Model fitting and projection were validated using the mean absolute percent error (MAPE). The transmission dynamics of COVID-19 was interrupted immediately by the lockdown. The modified SIR model projected the depleting temporal trends with lowest MAPE for I total, followed by I, I daily and R. During lockdown, the dynamics of COVID-19 depleted at a rate of 4.7% each day with a decreased capacity of 40%. For 7-day and 14-day projections, the modified SIR model accurately predicted I total, I and R. The depleting transmission dynamics for COVID-19 during lockdown can be accurately captured by time-varying SIR model. Projection generated based on observed data is useful for future planning and control of COVID-19. |
url |
https://doi.org/10.1038/s41598-020-78739-8 |
work_keys_str_mv |
AT kianboonlaw trackingtheearlydepletingtransmissiondynamicsofcovid19withatimevaryingsirmodel AT kalaiarasumpeariasamy trackingtheearlydepletingtransmissiondynamicsofcovid19withatimevaryingsirmodel AT balvindersinghgill trackingtheearlydepletingtransmissiondynamicsofcovid19withatimevaryingsirmodel AT sarbhansingh trackingtheearlydepletingtransmissiondynamicsofcovid19withatimevaryingsirmodel AT balamuralisundram trackingtheearlydepletingtransmissiondynamicsofcovid19withatimevaryingsirmodel AT kameshrajendran trackingtheearlydepletingtransmissiondynamicsofcovid19withatimevaryingsirmodel AT saratchandradass trackingtheearlydepletingtransmissiondynamicsofcovid19withatimevaryingsirmodel AT yilinlee trackingtheearlydepletingtransmissiondynamicsofcovid19withatimevaryingsirmodel AT pikpingoh trackingtheearlydepletingtransmissiondynamicsofcovid19withatimevaryingsirmodel AT hishamshahibrahim trackingtheearlydepletingtransmissiondynamicsofcovid19withatimevaryingsirmodel AT noorhishamabdullah trackingtheearlydepletingtransmissiondynamicsofcovid19withatimevaryingsirmodel |
_version_ |
1724384665102450688 |