CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir

CD32 has been previously shown to be expressed preferentially by CD4 T cells latently harbouring HIV-1. Here the authors show that CD32 expression in CD4 T cells is associated with T cell activation, is up-regulated by HIV-1 infection and importantly does not appear to represent an enriched cellular...

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Main Authors:	Roger Badia, Ester Ballana, Marc Castellví, Edurne García-Vidal, Maria Pujantell, Bonaventura Clotet, Julia G. Prado, Jordi Puig, Miguel A. Martínez, Eva Riveira-Muñoz, José A. Esté
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-05157-w

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spelling	doaj-7e50053306594d9bbbe279cb0c8a79022021-05-11T09:34:20ZengNature Publishing GroupNature Communications2041-17232018-07-019111010.1038/s41467-018-05157-wCD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoirRoger Badia0Ester Ballana1Marc Castellví2Edurne García-Vidal3Maria Pujantell4Bonaventura Clotet5Julia G. Prado6Jordi Puig7Miguel A. Martínez8Eva Riveira-Muñoz9José A. Esté10AIDS Research Institute-IrsiCaixa and Health Research Institute Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de BarcelonaAIDS Research Institute-IrsiCaixa and Health Research Institute Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de BarcelonaAIDS Research Institute-IrsiCaixa and Health Research Institute Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de BarcelonaAIDS Research Institute-IrsiCaixa and Health Research Institute Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de BarcelonaAIDS Research Institute-IrsiCaixa and Health Research Institute Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de BarcelonaAIDS Research Institute-IrsiCaixa and Health Research Institute Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de BarcelonaAIDS Research Institute-IrsiCaixa and Health Research Institute Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de BarcelonaAIDS Research Institute-IrsiCaixa and Health Research Institute Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de BarcelonaAIDS Research Institute-IrsiCaixa and Health Research Institute Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de BarcelonaAIDS Research Institute-IrsiCaixa and Health Research Institute Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de BarcelonaAIDS Research Institute-IrsiCaixa and Health Research Institute Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de BarcelonaCD32 has been previously shown to be expressed preferentially by CD4 T cells latently harbouring HIV-1. Here the authors show that CD32 expression in CD4 T cells is associated with T cell activation, is up-regulated by HIV-1 infection and importantly does not appear to represent an enriched cellular niche for latent HIV-1.https://doi.org/10.1038/s41467-018-05157-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Roger Badia Ester Ballana Marc Castellví Edurne García-Vidal Maria Pujantell Bonaventura Clotet Julia G. Prado Jordi Puig Miguel A. Martínez Eva Riveira-Muñoz José A. Esté
spellingShingle	Roger Badia Ester Ballana Marc Castellví Edurne García-Vidal Maria Pujantell Bonaventura Clotet Julia G. Prado Jordi Puig Miguel A. Martínez Eva Riveira-Muñoz José A. Esté CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir Nature Communications
author_facet	Roger Badia Ester Ballana Marc Castellví Edurne García-Vidal Maria Pujantell Bonaventura Clotet Julia G. Prado Jordi Puig Miguel A. Martínez Eva Riveira-Muñoz José A. Esté
author_sort	Roger Badia
title	CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir
title_short	CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir
title_full	CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir
title_fullStr	CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir
title_full_unstemmed	CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir
title_sort	cd32 expression is associated to t-cell activation and is not a marker of the hiv-1 reservoir
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-07-01
description	CD32 has been previously shown to be expressed preferentially by CD4 T cells latently harbouring HIV-1. Here the authors show that CD32 expression in CD4 T cells is associated with T cell activation, is up-regulated by HIV-1 infection and importantly does not appear to represent an enriched cellular niche for latent HIV-1.
url	https://doi.org/10.1038/s41467-018-05157-w
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CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir

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