A partially demineralized allogeneic bone graft: in vitro osteogenic potential and preclinical evaluation in two different intramembranous bone healing models
Abstract In skeletal surgical procedures, bone regeneration in irregular and hard-to-reach areas may present clinical challenges. In order to overcome the limitations of traditional autologous bone grafts and bone substitutes, an extrudable and easy-to-handle innovative partially demineralized allog...
Main Authors: | , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-03-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-021-84039-6 |
id |
doaj-7e57b958d5f045e599b25244a0048b33 |
---|---|
record_format |
Article |
spelling |
doaj-7e57b958d5f045e599b25244a0048b332021-03-11T12:11:02ZengNature Publishing GroupScientific Reports2045-23222021-03-0111111310.1038/s41598-021-84039-6A partially demineralized allogeneic bone graft: in vitro osteogenic potential and preclinical evaluation in two different intramembranous bone healing modelsPierre Tournier0Jérôme Guicheux1Arnaud Paré2Aymeric Maltezeanu3Thibaut Blondy4Joëlle Veziers5Caroline Vignes6Manon André7Julie Lesoeur8Ana Barbeito9Raphaël Bardonnet10Christophe Blanquart11Pierre Corre12Valérie Geoffroy13Pierre Weiss14Alexis Gaudin15INSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Université de Nantes, OnirisINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, CHU Nantes, Université de Nantes, OnirisINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Université de Nantes, OnirisINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Université de Nantes, OnirisUniversité de Nantes, Univ Angers, INSERM, CNRS, CRCINAINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, CHU Nantes, Université de Nantes, OnirisINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Université de Nantes, OnirisINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Université de Nantes, OnirisINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Université de Nantes, OnirisBIOBank SASBIOBank SASUniversité de Nantes, Univ Angers, INSERM, CNRS, CRCINAINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, CHU Nantes, Université de Nantes, OnirisINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Université de Nantes, OnirisINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, CHU Nantes, Université de Nantes, OnirisINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, CHU Nantes, Université de Nantes, OnirisAbstract In skeletal surgical procedures, bone regeneration in irregular and hard-to-reach areas may present clinical challenges. In order to overcome the limitations of traditional autologous bone grafts and bone substitutes, an extrudable and easy-to-handle innovative partially demineralized allogenic bone graft in the form of a paste has been developed. In this study, the regenerative potential of this paste was assessed and compared to its clinically used precursor form allogenic bone particles. Compared to the particular bone graft, the bone paste allowed better attachment of human mesenchymal stromal cells and their commitment towards the osteoblastic lineage, and it induced a pro-regenerative phenotype of human monocytes/macrophages. The bone paste also supported bone healing in vivo in a guide bone regeneration model and, more interestingly, exhibited a substantial bone-forming ability when implanted in a critical-size defect model in rat calvaria. Thus, these findings indicate that this novel partially demineralized allogeneic bone paste that combines substantial bone healing properties and rapid and ease-of-use may be a promising alternative to allogeneic bone grafts for bone regeneration in several clinical contexts of oral and maxillofacial bone grafting.https://doi.org/10.1038/s41598-021-84039-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pierre Tournier Jérôme Guicheux Arnaud Paré Aymeric Maltezeanu Thibaut Blondy Joëlle Veziers Caroline Vignes Manon André Julie Lesoeur Ana Barbeito Raphaël Bardonnet Christophe Blanquart Pierre Corre Valérie Geoffroy Pierre Weiss Alexis Gaudin |
spellingShingle |
Pierre Tournier Jérôme Guicheux Arnaud Paré Aymeric Maltezeanu Thibaut Blondy Joëlle Veziers Caroline Vignes Manon André Julie Lesoeur Ana Barbeito Raphaël Bardonnet Christophe Blanquart Pierre Corre Valérie Geoffroy Pierre Weiss Alexis Gaudin A partially demineralized allogeneic bone graft: in vitro osteogenic potential and preclinical evaluation in two different intramembranous bone healing models Scientific Reports |
author_facet |
Pierre Tournier Jérôme Guicheux Arnaud Paré Aymeric Maltezeanu Thibaut Blondy Joëlle Veziers Caroline Vignes Manon André Julie Lesoeur Ana Barbeito Raphaël Bardonnet Christophe Blanquart Pierre Corre Valérie Geoffroy Pierre Weiss Alexis Gaudin |
author_sort |
Pierre Tournier |
title |
A partially demineralized allogeneic bone graft: in vitro osteogenic potential and preclinical evaluation in two different intramembranous bone healing models |
title_short |
A partially demineralized allogeneic bone graft: in vitro osteogenic potential and preclinical evaluation in two different intramembranous bone healing models |
title_full |
A partially demineralized allogeneic bone graft: in vitro osteogenic potential and preclinical evaluation in two different intramembranous bone healing models |
title_fullStr |
A partially demineralized allogeneic bone graft: in vitro osteogenic potential and preclinical evaluation in two different intramembranous bone healing models |
title_full_unstemmed |
A partially demineralized allogeneic bone graft: in vitro osteogenic potential and preclinical evaluation in two different intramembranous bone healing models |
title_sort |
partially demineralized allogeneic bone graft: in vitro osteogenic potential and preclinical evaluation in two different intramembranous bone healing models |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-03-01 |
description |
Abstract In skeletal surgical procedures, bone regeneration in irregular and hard-to-reach areas may present clinical challenges. In order to overcome the limitations of traditional autologous bone grafts and bone substitutes, an extrudable and easy-to-handle innovative partially demineralized allogenic bone graft in the form of a paste has been developed. In this study, the regenerative potential of this paste was assessed and compared to its clinically used precursor form allogenic bone particles. Compared to the particular bone graft, the bone paste allowed better attachment of human mesenchymal stromal cells and their commitment towards the osteoblastic lineage, and it induced a pro-regenerative phenotype of human monocytes/macrophages. The bone paste also supported bone healing in vivo in a guide bone regeneration model and, more interestingly, exhibited a substantial bone-forming ability when implanted in a critical-size defect model in rat calvaria. Thus, these findings indicate that this novel partially demineralized allogeneic bone paste that combines substantial bone healing properties and rapid and ease-of-use may be a promising alternative to allogeneic bone grafts for bone regeneration in several clinical contexts of oral and maxillofacial bone grafting. |
url |
https://doi.org/10.1038/s41598-021-84039-6 |
work_keys_str_mv |
AT pierretournier apartiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT jeromeguicheux apartiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT arnaudpare apartiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT aymericmaltezeanu apartiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT thibautblondy apartiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT joelleveziers apartiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT carolinevignes apartiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT manonandre apartiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT julielesoeur apartiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT anabarbeito apartiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT raphaelbardonnet apartiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT christopheblanquart apartiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT pierrecorre apartiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT valeriegeoffroy apartiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT pierreweiss apartiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT alexisgaudin apartiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT pierretournier partiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT jeromeguicheux partiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT arnaudpare partiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT aymericmaltezeanu partiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT thibautblondy partiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT joelleveziers partiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT carolinevignes partiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT manonandre partiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT julielesoeur partiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT anabarbeito partiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT raphaelbardonnet partiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT christopheblanquart partiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT pierrecorre partiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT valeriegeoffroy partiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT pierreweiss partiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels AT alexisgaudin partiallydemineralizedallogeneicbonegraftinvitroosteogenicpotentialandpreclinicalevaluationintwodifferentintramembranousbonehealingmodels |
_version_ |
1724224698022100992 |