Estrogen Regulation of mTOR Signaling and Mitochondrial Function in Invasive Lobular Carcinoma Cell Lines Requires WNT4

Estrogen Regulation of mTOR Signaling and Mitochondrial Function in Invasive Lobular Carcinoma Cell Lines Requires WNT4

Invasive lobular carcinoma of the breast (ILC) is strongly estrogen-driven and represents a unique context for estrogen receptor (ER) signaling. In ILC, ER controls the expression of the Wnt ligand WNT4, which is critical for endocrine response and anti-estrogen resistance. However, signaling mediat...

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Bibliographic Details
Main Authors: Madeleine T. Shackleford, Deviyani M. Rao, Evelyn K. Bordeaux, Hannah M. Hicks, Christina G. Towers, Joseph L. Sottnik, Steffi Oesterreich, Matthew J. Sikora
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
WNT4
Wnt signaling
estrogen
estrogen receptor
breast cancer
lobular carcinoma
Online Access:https://www.mdpi.com/2072-6694/12/10/2931

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