“Semantic variant primary progressive aphasia” due to comorbidity of Lewy body disease and a previous cerebral venous infarction in the left anterior temporal lobe: A case report
Primary progressive aphasia (PPA) is a neurological syndrome characterized by progressive language impairment. Various neurodegenerative disorders cause PPA. Dementia with Lewy bodies (DLB) is one known cause of PPA, and little is known about this association. Almost all published cases of PPA assoc...
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doaj-7e58c8b34bde4aa8a0b631fef0b3f4fb2021-02-21T04:34:39ZengElseviereNeurologicalSci2405-65022021-03-0122100318“Semantic variant primary progressive aphasia” due to comorbidity of Lewy body disease and a previous cerebral venous infarction in the left anterior temporal lobe: A case reportKazuo Kakinuma0Wataru Narita1Toru Baba2Osamu Iizuka3Yoshiyuki Nishio4Kyoko Suzuki5Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan; Corresponding authors at: Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Sendai 980-8575, Japan.Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Neurology, National Hospital Organization Sendai-Nishitaga Hospital, Sendai, JapanDepartment of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Psychiatry & Neurology, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, JapanDepartment of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan; Corresponding authors at: Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Sendai 980-8575, Japan.Primary progressive aphasia (PPA) is a neurological syndrome characterized by progressive language impairment. Various neurodegenerative disorders cause PPA. Dementia with Lewy bodies (DLB) is one known cause of PPA, and little is known about this association. Almost all published cases of PPA associated with DLB are the logopenic variant of PPA. Here, we describe the novel case of a patient with DLB presenting clinical features of the semantic variant PPA (svPPA). A 75-year-old woman was referred to our hospital with a 2-year history of progressive anomia and amnesia. Two months before admission, she had been experiencing visual hallucinations, and at the age of 60 years, she had venous infarction in the left temporal lobe, which she recovered from without any residual symptoms. Upon admission to our hospital, she displayed anomia, impaired single-word comprehension, and surface dyslexia with preserved repetition and speech production. These symptoms met the criteria for the diagnosis of svPPA. 123I-ioflupane single-photon emission computed tomography and 123I-meta-iodobenzylguanidine myocardial scintigraphy indicated DLB. Thus, she was administered donepezil, and this dramatically improved her symptoms. We hypothesize that the combination of DLB with the previous asymptomatic venous thrombosis in the left temporal lobe may have contributed to the “svPPA” in this patient. In conclusion, we show that PPA associated with DLB could be treated with donepezil, and we suggest that donepezil should be pursued as a treatment option for PPA.http://www.sciencedirect.com/science/article/pii/S2405650221000101Dementia with Lewy bodiesPrimary progressive aphasiaStrokeSemantic dementiaTreatmentDonepezil |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kazuo Kakinuma Wataru Narita Toru Baba Osamu Iizuka Yoshiyuki Nishio Kyoko Suzuki |
spellingShingle |
Kazuo Kakinuma Wataru Narita Toru Baba Osamu Iizuka Yoshiyuki Nishio Kyoko Suzuki “Semantic variant primary progressive aphasia” due to comorbidity of Lewy body disease and a previous cerebral venous infarction in the left anterior temporal lobe: A case report eNeurologicalSci Dementia with Lewy bodies Primary progressive aphasia Stroke Semantic dementia Treatment Donepezil |
author_facet |
Kazuo Kakinuma Wataru Narita Toru Baba Osamu Iizuka Yoshiyuki Nishio Kyoko Suzuki |
author_sort |
Kazuo Kakinuma |
title |
“Semantic variant primary progressive aphasia” due to comorbidity of Lewy body disease and a previous cerebral venous infarction in the left anterior temporal lobe: A case report |
title_short |
“Semantic variant primary progressive aphasia” due to comorbidity of Lewy body disease and a previous cerebral venous infarction in the left anterior temporal lobe: A case report |
title_full |
“Semantic variant primary progressive aphasia” due to comorbidity of Lewy body disease and a previous cerebral venous infarction in the left anterior temporal lobe: A case report |
title_fullStr |
“Semantic variant primary progressive aphasia” due to comorbidity of Lewy body disease and a previous cerebral venous infarction in the left anterior temporal lobe: A case report |
title_full_unstemmed |
“Semantic variant primary progressive aphasia” due to comorbidity of Lewy body disease and a previous cerebral venous infarction in the left anterior temporal lobe: A case report |
title_sort |
“semantic variant primary progressive aphasia” due to comorbidity of lewy body disease and a previous cerebral venous infarction in the left anterior temporal lobe: a case report |
publisher |
Elsevier |
series |
eNeurologicalSci |
issn |
2405-6502 |
publishDate |
2021-03-01 |
description |
Primary progressive aphasia (PPA) is a neurological syndrome characterized by progressive language impairment. Various neurodegenerative disorders cause PPA. Dementia with Lewy bodies (DLB) is one known cause of PPA, and little is known about this association. Almost all published cases of PPA associated with DLB are the logopenic variant of PPA. Here, we describe the novel case of a patient with DLB presenting clinical features of the semantic variant PPA (svPPA). A 75-year-old woman was referred to our hospital with a 2-year history of progressive anomia and amnesia. Two months before admission, she had been experiencing visual hallucinations, and at the age of 60 years, she had venous infarction in the left temporal lobe, which she recovered from without any residual symptoms. Upon admission to our hospital, she displayed anomia, impaired single-word comprehension, and surface dyslexia with preserved repetition and speech production. These symptoms met the criteria for the diagnosis of svPPA. 123I-ioflupane single-photon emission computed tomography and 123I-meta-iodobenzylguanidine myocardial scintigraphy indicated DLB. Thus, she was administered donepezil, and this dramatically improved her symptoms. We hypothesize that the combination of DLB with the previous asymptomatic venous thrombosis in the left temporal lobe may have contributed to the “svPPA” in this patient. In conclusion, we show that PPA associated with DLB could be treated with donepezil, and we suggest that donepezil should be pursued as a treatment option for PPA. |
topic |
Dementia with Lewy bodies Primary progressive aphasia Stroke Semantic dementia Treatment Donepezil |
url |
http://www.sciencedirect.com/science/article/pii/S2405650221000101 |
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