Attenuation Correction Approaches for Serotonin Transporter Quantification With PET/MRI

• Main Authors: Lucas Rischka, Gregor Gryglewski, Neydher Berroterán-Infante, Ivo Rausch, Gregory Miles James, Manfred Klöbl, Helen Sigurdardottir, Markus Hartenbach, Andreas Hahn, Wolfgang Wadsak, Markus Mitterhauser, Thomas Beyer, Siegfried Kasper, Daniela Prayer, Marcus Hacker, Rupert Lanzenberger
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2019-11-01
• Series: Frontiers in Physiology
• Subjects: attenuation correction; PET/MRI; serotonin transporter; [11C]DASB; occupancy; absolute quantification
• Online Access: https://www.frontiersin.org/article/10.3389/fphys.2019.01422/full

BackgroundSeveral MR-based attenuation correction (AC) approaches were developed to conquer the challenging AC in hybrid PET/MR imaging. These AC methods are commonly evaluated on standardized uptake values or tissue concentration. However, in neurotransmitter system studies absolute quantification is more favorable due to its accuracy. Therefore, our aim was to investigate the accuracy of segmentation- and atlas-based MR AC approaches on serotonin transporter (SERT) distribution volumes and occupancy after a drug challenge.Methods18 healthy subjects (7 male) underwent two [11C]DASB PET/MRI measurements in a double-blinded, placebo controlled, cross-over design. After 70 min the selective serotonin reuptake inhibitor (SSRI) citalopram or a placebo was infused. The parameters total and specific volume of distribution (VT, VS = BPP) and occupancy were quantified. All subjects underwent a low-dose CT scan as reference AC method. Besides the standard AC approaches DIXON and UTE, a T1-weighted structural image was recorded to estimate a pseudo-CT based on an MR/CT database (pseudoCT). Another evaluated AC approach superimposed a bone model on AC DIXON. Lastly, an approach optimizing the segmentation of UTE images was analyzed (RESOLUTE). PET emission data were reconstructed with all 6 AC methods. The accuracy of the AC approaches was evaluated on a region of interest-basis for the parameters VT, BPP, and occupancy with respect to the results of AC CT.ResultsVariations for VT and BPP were found with all AC methods with bias ranging from −15 to 17%. The smallest relative errors for all regions were found with AC pseudoCT (<|5%|). Although the bias between BPP SSRI and BPP placebo varied markedly with AC DIXON (<|12%|) and AC UTE (<|9%|), a high correlation to AC CT was obtained (r2∼1). The relative difference of the occupancy for all tested AC methods was small for SERT high binding regions (<|4%|).ConclusionThe high correlation might offer a rescaling from the biased parameters VT and BPP to the true values. Overall, the pseudoCT approach yielded smallest errors and the best agreement with AC CT. For SERT occupancy, all AC methods showed little bias in high binding regions, indicating that errors may cancel out in longitudinal assessments.