Attenuation Correction Approaches for Serotonin Transporter Quantification With PET/MRI
BackgroundSeveral MR-based attenuation correction (AC) approaches were developed to conquer the challenging AC in hybrid PET/MR imaging. These AC methods are commonly evaluated on standardized uptake values or tissue concentration. However, in neurotransmitter system studies absolute quantification...
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Frontiers Media S.A.
2019-11-01
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Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2019.01422/full |
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doaj-7e5d790830304197bdc088e565bce28f |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lucas Rischka Gregor Gryglewski Neydher Berroterán-Infante Ivo Rausch Gregory Miles James Manfred Klöbl Helen Sigurdardottir Markus Hartenbach Andreas Hahn Wolfgang Wadsak Wolfgang Wadsak Markus Mitterhauser Markus Mitterhauser Thomas Beyer Siegfried Kasper Daniela Prayer Marcus Hacker Rupert Lanzenberger |
spellingShingle |
Lucas Rischka Gregor Gryglewski Neydher Berroterán-Infante Ivo Rausch Gregory Miles James Manfred Klöbl Helen Sigurdardottir Markus Hartenbach Andreas Hahn Wolfgang Wadsak Wolfgang Wadsak Markus Mitterhauser Markus Mitterhauser Thomas Beyer Siegfried Kasper Daniela Prayer Marcus Hacker Rupert Lanzenberger Attenuation Correction Approaches for Serotonin Transporter Quantification With PET/MRI Frontiers in Physiology attenuation correction PET/MRI serotonin transporter [11C]DASB occupancy absolute quantification |
author_facet |
Lucas Rischka Gregor Gryglewski Neydher Berroterán-Infante Ivo Rausch Gregory Miles James Manfred Klöbl Helen Sigurdardottir Markus Hartenbach Andreas Hahn Wolfgang Wadsak Wolfgang Wadsak Markus Mitterhauser Markus Mitterhauser Thomas Beyer Siegfried Kasper Daniela Prayer Marcus Hacker Rupert Lanzenberger |
author_sort |
Lucas Rischka |
title |
Attenuation Correction Approaches for Serotonin Transporter Quantification With PET/MRI |
title_short |
Attenuation Correction Approaches for Serotonin Transporter Quantification With PET/MRI |
title_full |
Attenuation Correction Approaches for Serotonin Transporter Quantification With PET/MRI |
title_fullStr |
Attenuation Correction Approaches for Serotonin Transporter Quantification With PET/MRI |
title_full_unstemmed |
Attenuation Correction Approaches for Serotonin Transporter Quantification With PET/MRI |
title_sort |
attenuation correction approaches for serotonin transporter quantification with pet/mri |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2019-11-01 |
description |
BackgroundSeveral MR-based attenuation correction (AC) approaches were developed to conquer the challenging AC in hybrid PET/MR imaging. These AC methods are commonly evaluated on standardized uptake values or tissue concentration. However, in neurotransmitter system studies absolute quantification is more favorable due to its accuracy. Therefore, our aim was to investigate the accuracy of segmentation- and atlas-based MR AC approaches on serotonin transporter (SERT) distribution volumes and occupancy after a drug challenge.Methods18 healthy subjects (7 male) underwent two [11C]DASB PET/MRI measurements in a double-blinded, placebo controlled, cross-over design. After 70 min the selective serotonin reuptake inhibitor (SSRI) citalopram or a placebo was infused. The parameters total and specific volume of distribution (VT, VS = BPP) and occupancy were quantified. All subjects underwent a low-dose CT scan as reference AC method. Besides the standard AC approaches DIXON and UTE, a T1-weighted structural image was recorded to estimate a pseudo-CT based on an MR/CT database (pseudoCT). Another evaluated AC approach superimposed a bone model on AC DIXON. Lastly, an approach optimizing the segmentation of UTE images was analyzed (RESOLUTE). PET emission data were reconstructed with all 6 AC methods. The accuracy of the AC approaches was evaluated on a region of interest-basis for the parameters VT, BPP, and occupancy with respect to the results of AC CT.ResultsVariations for VT and BPP were found with all AC methods with bias ranging from −15 to 17%. The smallest relative errors for all regions were found with AC pseudoCT (<|5%|). Although the bias between BPP SSRI and BPP placebo varied markedly with AC DIXON (<|12%|) and AC UTE (<|9%|), a high correlation to AC CT was obtained (r2∼1). The relative difference of the occupancy for all tested AC methods was small for SERT high binding regions (<|4%|).ConclusionThe high correlation might offer a rescaling from the biased parameters VT and BPP to the true values. Overall, the pseudoCT approach yielded smallest errors and the best agreement with AC CT. For SERT occupancy, all AC methods showed little bias in high binding regions, indicating that errors may cancel out in longitudinal assessments. |
topic |
attenuation correction PET/MRI serotonin transporter [11C]DASB occupancy absolute quantification |
url |
https://www.frontiersin.org/article/10.3389/fphys.2019.01422/full |
work_keys_str_mv |
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doaj-7e5d790830304197bdc088e565bce28f2020-11-25T01:12:34ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-11-011010.3389/fphys.2019.01422469884Attenuation Correction Approaches for Serotonin Transporter Quantification With PET/MRILucas Rischka0Gregor Gryglewski1Neydher Berroterán-Infante2Ivo Rausch3Gregory Miles James4Manfred Klöbl5Helen Sigurdardottir6Markus Hartenbach7Andreas Hahn8Wolfgang Wadsak9Wolfgang Wadsak10Markus Mitterhauser11Markus Mitterhauser12Thomas Beyer13Siegfried Kasper14Daniela Prayer15Marcus Hacker16Rupert Lanzenberger17Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, AustriaDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, AustriaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, AustriaQIMP Group, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, AustriaDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, AustriaDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, AustriaDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, AustriaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, AustriaDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, AustriaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, AustriaCBmed, Graz, AustriaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, AustriaLudwig Boltzmann Institute Applied Diagnostics, Vienna, AustriaQIMP Group, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, AustriaDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, AustriaDivision of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, AustriaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, AustriaDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, AustriaBackgroundSeveral MR-based attenuation correction (AC) approaches were developed to conquer the challenging AC in hybrid PET/MR imaging. These AC methods are commonly evaluated on standardized uptake values or tissue concentration. However, in neurotransmitter system studies absolute quantification is more favorable due to its accuracy. Therefore, our aim was to investigate the accuracy of segmentation- and atlas-based MR AC approaches on serotonin transporter (SERT) distribution volumes and occupancy after a drug challenge.Methods18 healthy subjects (7 male) underwent two [11C]DASB PET/MRI measurements in a double-blinded, placebo controlled, cross-over design. After 70 min the selective serotonin reuptake inhibitor (SSRI) citalopram or a placebo was infused. The parameters total and specific volume of distribution (VT, VS = BPP) and occupancy were quantified. All subjects underwent a low-dose CT scan as reference AC method. Besides the standard AC approaches DIXON and UTE, a T1-weighted structural image was recorded to estimate a pseudo-CT based on an MR/CT database (pseudoCT). Another evaluated AC approach superimposed a bone model on AC DIXON. Lastly, an approach optimizing the segmentation of UTE images was analyzed (RESOLUTE). PET emission data were reconstructed with all 6 AC methods. The accuracy of the AC approaches was evaluated on a region of interest-basis for the parameters VT, BPP, and occupancy with respect to the results of AC CT.ResultsVariations for VT and BPP were found with all AC methods with bias ranging from −15 to 17%. The smallest relative errors for all regions were found with AC pseudoCT (<|5%|). Although the bias between BPP SSRI and BPP placebo varied markedly with AC DIXON (<|12%|) and AC UTE (<|9%|), a high correlation to AC CT was obtained (r2∼1). The relative difference of the occupancy for all tested AC methods was small for SERT high binding regions (<|4%|).ConclusionThe high correlation might offer a rescaling from the biased parameters VT and BPP to the true values. Overall, the pseudoCT approach yielded smallest errors and the best agreement with AC CT. For SERT occupancy, all AC methods showed little bias in high binding regions, indicating that errors may cancel out in longitudinal assessments.https://www.frontiersin.org/article/10.3389/fphys.2019.01422/fullattenuation correctionPET/MRIserotonin transporter[11C]DASBoccupancyabsolute quantification |