Associations of Estrogen Receptor, Progesterone Receptor, Human Epidemic Growth Factor Receptor-2 and Ki-67 with Ultrasound Signs and Prognosis of Breast Cancer Patients

• Main Authors: Zhao X, Yang X, Fu L, Yu K
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-06-01
• Series: Cancer Management and Research
• Subjects: estrogen receptor; progesterone receptor; human epidemic growth factor receptor-2; ki-67; breast cancer; ultrasound signs; prognosis
• Online Access: https://www.dovepress.com/associations-of-estrogen-receptor-progesterone-receptor-human-epidemic-peer-reviewed-fulltext-article-CMAR

Xingjuan Zhao,1 Xuan Yang,1 Lei Fu,2 Keda Yu3 1Department of Mammary Gland, Shanxi People’s Hospital, Taiyuan City, Shanxi Province, 030000, People’s Republic of China; 2Department of Surgery, Shanxi Provincial General Team Hospital of the Chinese People’s Armed Police Force, Taiyuan City, Shanxi Province, 030000, People’s Republic of China; 3Department of Mammary Gland, Fudan University Cancer Hospital, Taiyuan City, Shanxi Province, 030000, People’s Republic of ChinaCorrespondence: Xingjuan ZhaoDepartment of Mammary Gland, Shanxi People’s Hospital, No. 29 Shuangtasi Street, Taiyuan City, Shanxi Province, 030000, People’s Republic of ChinaEmail [e-mail]: The functions of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki-67 in breast cancer have been explored. This study was carried out to explore ER, PR, HER-2 and Ki-67 expression levels in breast cancer patients and their relationship with ultrasound signs and prognosis.Patients and Methods: A total of 274 female primary breast cancer patients received preoperative ultrasound examination. ER, PR, HER-2 and Ki-67 expression levels in breast cancer tissues were detected by immunohistochemical staining after surgery. The correlations of ER, PR, HER-2 and Ki-67 expression with ultrasound signs and prognosis of breast cancer patients were analyzed.Results: The positive expression rate of ER, PR and HER-2 and Ki-67 high expression in 274 breast cancer patients was 73.36% (201/274), 59.85% (164/274), 24.09% (66/274) and 66.06% (181/274), respectively. ER-positive expression had association with lymph node metastasis (LNM) and blood flow grading; HER-2-positive expression was associated with LNM, while Ki-67-positive expression was related to the tumor diameter, LNM, and blood flow grading. LNM and Ki-67 high expression were risk factors for OS; PR-positive was a protective factor for OS; TNM stage, tumor diameter, LNM and Ki-67 high expression were risk factors for DFS in breast cancer patients.Conclusion: ER, PR, HER-2 and Ki-67 in breast cancer are related to the ultrasound signs and prognosis of breast cancer patients. The joint detection of multiple indicators provides a reference for the individualized treatment of targeted drugs.Keywords: estrogen receptor, progesterone receptor, human epidemic growth factor receptor-2, Ki-67, breast cancer, ultrasound signs, prognosis