Single molecule mechanics resolves the earliest events in force generation by cardiac myosin
Key steps of cardiac mechanochemistry, including the force-generating working stroke and the release of phosphate (Pi), occur rapidly after myosin-actin attachment. An ultra-high-speed optical trap enabled direct observation of the timing and amplitude of the working stroke, which can occur within &...
Main Authors: | Michael S Woody, Donald A Winkelmann, Marco Capitanio, E Michael Ostap, Yale E Goldman |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-09-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/49266 |
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