Factors Regulating microRNA Expression and Function in Multiple Myeloma
Intensive research has been undertaken during the last decade to identify the implication of microRNAs (miRNAs) in the pathogenesis of multiple myeloma (MM). The expression profiling of miRNAs in MM has provided relevant information, demonstrating different patterns of miRNA expression depending on...
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doaj-7e65c981bf8644f98c10351d268b6eaf2020-11-25T02:15:23ZengMDPI AGNon-Coding RNA2311-553X2019-01-0151910.3390/ncrna5010009ncrna5010009Factors Regulating microRNA Expression and Function in Multiple MyelomaIrena Misiewicz-Krzeminska0Patryk Krzeminski1Luis A. Corchete2Dalia Quwaider3Elizabeta A. Rojas4Ana Belén Herrero5Norma C. Gutiérrez6The Institute for Biomedical Research (IBSAL), 37007 Salamanca, SpainThe Institute for Biomedical Research (IBSAL), 37007 Salamanca, SpainThe Institute for Biomedical Research (IBSAL), 37007 Salamanca, SpainThe Institute for Biomedical Research (IBSAL), 37007 Salamanca, SpainThe Institute for Biomedical Research (IBSAL), 37007 Salamanca, SpainThe Institute for Biomedical Research (IBSAL), 37007 Salamanca, SpainThe Institute for Biomedical Research (IBSAL), 37007 Salamanca, SpainIntensive research has been undertaken during the last decade to identify the implication of microRNAs (miRNAs) in the pathogenesis of multiple myeloma (MM). The expression profiling of miRNAs in MM has provided relevant information, demonstrating different patterns of miRNA expression depending on the genetic abnormalities of MM and a key role of some miRNAs regulating critical genes associated with MM pathogenesis. However, the underlying causes of abnormal expression of miRNAs in myeloma cells remain mainly elusive. The final expression of the mature miRNAs is subject to multiple regulation mechanisms, such as copy number alterations, CpG methylation or transcription factors, together with impairment in miRNA biogenesis and differences in availability of the mRNA target sequence. In this review, we summarize the available knowledge about the factors involved in the regulation of miRNA expression and functionality in MM.http://www.mdpi.com/2311-553X/5/1/9miRNAmyeloma multiplemiRNA regulationmethylation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Irena Misiewicz-Krzeminska Patryk Krzeminski Luis A. Corchete Dalia Quwaider Elizabeta A. Rojas Ana Belén Herrero Norma C. Gutiérrez |
spellingShingle |
Irena Misiewicz-Krzeminska Patryk Krzeminski Luis A. Corchete Dalia Quwaider Elizabeta A. Rojas Ana Belén Herrero Norma C. Gutiérrez Factors Regulating microRNA Expression and Function in Multiple Myeloma Non-Coding RNA miRNA myeloma multiple miRNA regulation methylation |
author_facet |
Irena Misiewicz-Krzeminska Patryk Krzeminski Luis A. Corchete Dalia Quwaider Elizabeta A. Rojas Ana Belén Herrero Norma C. Gutiérrez |
author_sort |
Irena Misiewicz-Krzeminska |
title |
Factors Regulating microRNA Expression and Function in Multiple Myeloma |
title_short |
Factors Regulating microRNA Expression and Function in Multiple Myeloma |
title_full |
Factors Regulating microRNA Expression and Function in Multiple Myeloma |
title_fullStr |
Factors Regulating microRNA Expression and Function in Multiple Myeloma |
title_full_unstemmed |
Factors Regulating microRNA Expression and Function in Multiple Myeloma |
title_sort |
factors regulating microrna expression and function in multiple myeloma |
publisher |
MDPI AG |
series |
Non-Coding RNA |
issn |
2311-553X |
publishDate |
2019-01-01 |
description |
Intensive research has been undertaken during the last decade to identify the implication of microRNAs (miRNAs) in the pathogenesis of multiple myeloma (MM). The expression profiling of miRNAs in MM has provided relevant information, demonstrating different patterns of miRNA expression depending on the genetic abnormalities of MM and a key role of some miRNAs regulating critical genes associated with MM pathogenesis. However, the underlying causes of abnormal expression of miRNAs in myeloma cells remain mainly elusive. The final expression of the mature miRNAs is subject to multiple regulation mechanisms, such as copy number alterations, CpG methylation or transcription factors, together with impairment in miRNA biogenesis and differences in availability of the mRNA target sequence. In this review, we summarize the available knowledge about the factors involved in the regulation of miRNA expression and functionality in MM. |
topic |
miRNA myeloma multiple miRNA regulation methylation |
url |
http://www.mdpi.com/2311-553X/5/1/9 |
work_keys_str_mv |
AT irenamisiewiczkrzeminska factorsregulatingmicrornaexpressionandfunctioninmultiplemyeloma AT patrykkrzeminski factorsregulatingmicrornaexpressionandfunctioninmultiplemyeloma AT luisacorchete factorsregulatingmicrornaexpressionandfunctioninmultiplemyeloma AT daliaquwaider factorsregulatingmicrornaexpressionandfunctioninmultiplemyeloma AT elizabetaarojas factorsregulatingmicrornaexpressionandfunctioninmultiplemyeloma AT anabelenherrero factorsregulatingmicrornaexpressionandfunctioninmultiplemyeloma AT normacgutierrez factorsregulatingmicrornaexpressionandfunctioninmultiplemyeloma |
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1724896868613226496 |