Liposomal extended-release bupivacaine for postsurgical analgesia
Mark Lambrechts,1,2 Michael J O’Brien,2 Felix H Savoie,2 Zongbing You1–31Department of Structural and Cellular Biology, 2Department of Orthopaedic Surgery and Tulane Institute of Sports Medicine, 3Tulane Cancer Center, Louisiana Cancer Research Consortium, Tulane Center for Aging...
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2013-09-01
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doaj-7e6a965d81f44d938a854fa683bf26652020-11-25T01:18:10ZengDove Medical PressPatient Preference and Adherence1177-889X2013-09-012013default885890Liposomal extended-release bupivacaine for postsurgical analgesiaLambrechts MO’Brien MJSavoie FHYou ZMark Lambrechts,1,2 Michael J O’Brien,2 Felix H Savoie,2 Zongbing You1–31Department of Structural and Cellular Biology, 2Department of Orthopaedic Surgery and Tulane Institute of Sports Medicine, 3Tulane Cancer Center, Louisiana Cancer Research Consortium, Tulane Center for Aging, Tulane Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USAAbstract: When physicians consider which analgesia to use postsurgery, the primary goal is to relieve pain with minimal adverse side effects. Bupivacaine, a commonly used analgesic, has been formulated into an aqueous suspension of multivesicular liposomes that provide long-lasting analgesia for up to 72 hours, while avoiding the adverse side effects of opioids. The increased efficacy of liposomal extended-release bupivacaine, compared to bupivacaine hydrochloride, has promoted its usage in a variety of surgeries including hemorrhoidectomy, bunionectomy, inguinal hernia repair, total knee arthroplasty, and augmentation mammoplasty. However, like other bupivacaine formulations, the liposomal extended-release bupivacaine does have some side effects. In this brief review, we provide an update of the current knowledge in the use of bupivacaine for postsurgical analgesia. Keywords: bupivacaine, liposome, analgesia, side effects, efficacy, patient satisfactionhttp://www.dovepress.com/liposomal-extended-release-bupivacaine-for-postsurgical-analgesia-a14283 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lambrechts M O’Brien MJ Savoie FH You Z |
spellingShingle |
Lambrechts M O’Brien MJ Savoie FH You Z Liposomal extended-release bupivacaine for postsurgical analgesia Patient Preference and Adherence |
author_facet |
Lambrechts M O’Brien MJ Savoie FH You Z |
author_sort |
Lambrechts M |
title |
Liposomal extended-release bupivacaine for postsurgical analgesia |
title_short |
Liposomal extended-release bupivacaine for postsurgical analgesia |
title_full |
Liposomal extended-release bupivacaine for postsurgical analgesia |
title_fullStr |
Liposomal extended-release bupivacaine for postsurgical analgesia |
title_full_unstemmed |
Liposomal extended-release bupivacaine for postsurgical analgesia |
title_sort |
liposomal extended-release bupivacaine for postsurgical analgesia |
publisher |
Dove Medical Press |
series |
Patient Preference and Adherence |
issn |
1177-889X |
publishDate |
2013-09-01 |
description |
Mark Lambrechts,1,2 Michael J O’Brien,2 Felix H Savoie,2 Zongbing You1–31Department of Structural and Cellular Biology, 2Department of Orthopaedic Surgery and Tulane Institute of Sports Medicine, 3Tulane Cancer Center, Louisiana Cancer Research Consortium, Tulane Center for Aging, Tulane Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USAAbstract: When physicians consider which analgesia to use postsurgery, the primary goal is to relieve pain with minimal adverse side effects. Bupivacaine, a commonly used analgesic, has been formulated into an aqueous suspension of multivesicular liposomes that provide long-lasting analgesia for up to 72 hours, while avoiding the adverse side effects of opioids. The increased efficacy of liposomal extended-release bupivacaine, compared to bupivacaine hydrochloride, has promoted its usage in a variety of surgeries including hemorrhoidectomy, bunionectomy, inguinal hernia repair, total knee arthroplasty, and augmentation mammoplasty. However, like other bupivacaine formulations, the liposomal extended-release bupivacaine does have some side effects. In this brief review, we provide an update of the current knowledge in the use of bupivacaine for postsurgical analgesia. Keywords: bupivacaine, liposome, analgesia, side effects, efficacy, patient satisfaction |
url |
http://www.dovepress.com/liposomal-extended-release-bupivacaine-for-postsurgical-analgesia-a14283 |
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