CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury

Carboxyl terminus of Hsc70-interacting protein (CHIP) is proteostasis regulator. Here the authors show that CHIP-mediated protein turnover is enhanced by PKG-mediated phosphorylation, which results in attenuated cardiac ischemic proteotoxicity.

Bibliographic Details
Main Authors:	Mark J. Ranek, Christian Oeing, Rebekah Sanchez-Hodge, Kristen M. Kokkonen-Simon, Danielle Dillard, M. Imran Aslam, Peter P. Rainer, Sumita Mishra, Brittany Dunkerly-Eyring, Ronald J. Holewinski, Cornelia Virus, Huaqun Zhang, Matthew M. Mannion, Vineet Agrawal, Virginia Hahn, Dong I. Lee, Masayuki Sasaki, Jennifer E. Van Eyk, Monte S. Willis, Richard C. Page, Jonathan C. Schisler, David A. Kass
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18980-x

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spelling	doaj-7e6f8490744a4cef9d24e2c03e23c4992021-05-11T09:18:15ZengNature Publishing GroupNature Communications2041-17232020-10-0111111210.1038/s41467-020-18980-xCHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injuryMark J. Ranek0Christian Oeing1Rebekah Sanchez-Hodge2Kristen M. Kokkonen-Simon3Danielle Dillard4M. Imran Aslam5Peter P. Rainer6Sumita Mishra7Brittany Dunkerly-Eyring8Ronald J. Holewinski9Cornelia Virus10Huaqun Zhang11Matthew M. Mannion12Vineet Agrawal13Virginia Hahn14Dong I. Lee15Masayuki Sasaki16Jennifer E. Van Eyk17Monte S. Willis18Richard C. Page19Jonathan C. Schisler20David A. Kass21Division of Cardiology, Department of Medicine, Johns Hopkins Medical InstitutionsDivision of Cardiology, Department of Medicine, Johns Hopkins Medical InstitutionsDivision of Cardiology, McAllister Heart Institute, The University of North Carolina at Chapel HillDivision of Cardiology, Department of Medicine, Johns Hopkins Medical InstitutionsDivision of Cardiology, Department of Medicine, Johns Hopkins Medical InstitutionsDivision of Cardiology, Department of Medicine, Johns Hopkins Medical InstitutionsDivision of Cardiology, Department of Medicine, Johns Hopkins Medical InstitutionsDivision of Cardiology, Department of Medicine, Johns Hopkins Medical InstitutionsDivision of Cardiology, Department of Medicine, Johns Hopkins Medical InstitutionsCedar Sinai Medical Center, Advanced Clinical Biosystems Research Institute, The Smidt Heart InstituteDivision of Cardiology, McAllister Heart Institute, The University of North Carolina at Chapel HillDepartment of Chemistry and Biochemistry, Miami UniversityDepartment of Chemistry and Biochemistry, Miami UniversityDivision of Cardiology, Department of Medicine, Johns Hopkins Medical InstitutionsDivision of Cardiology, Department of Medicine, Johns Hopkins Medical InstitutionsDivision of Cardiology, Department of Medicine, Johns Hopkins Medical InstitutionsDivision of Cardiology, Department of Medicine, Johns Hopkins Medical InstitutionsCedar Sinai Medical Center, Advanced Clinical Biosystems Research Institute, The Smidt Heart InstituteDivision of Cardiology, McAllister Heart Institute, The University of North Carolina at Chapel HillDepartment of Chemistry and Biochemistry, Miami UniversityDivision of Cardiology, McAllister Heart Institute, The University of North Carolina at Chapel HillDivision of Cardiology, Department of Medicine, Johns Hopkins Medical InstitutionsCarboxyl terminus of Hsc70-interacting protein (CHIP) is proteostasis regulator. Here the authors show that CHIP-mediated protein turnover is enhanced by PKG-mediated phosphorylation, which results in attenuated cardiac ischemic proteotoxicity.https://doi.org/10.1038/s41467-020-18980-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mark J. Ranek Christian Oeing Rebekah Sanchez-Hodge Kristen M. Kokkonen-Simon Danielle Dillard M. Imran Aslam Peter P. Rainer Sumita Mishra Brittany Dunkerly-Eyring Ronald J. Holewinski Cornelia Virus Huaqun Zhang Matthew M. Mannion Vineet Agrawal Virginia Hahn Dong I. Lee Masayuki Sasaki Jennifer E. Van Eyk Monte S. Willis Richard C. Page Jonathan C. Schisler David A. Kass
spellingShingle	Mark J. Ranek Christian Oeing Rebekah Sanchez-Hodge Kristen M. Kokkonen-Simon Danielle Dillard M. Imran Aslam Peter P. Rainer Sumita Mishra Brittany Dunkerly-Eyring Ronald J. Holewinski Cornelia Virus Huaqun Zhang Matthew M. Mannion Vineet Agrawal Virginia Hahn Dong I. Lee Masayuki Sasaki Jennifer E. Van Eyk Monte S. Willis Richard C. Page Jonathan C. Schisler David A. Kass CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury Nature Communications
author_facet	Mark J. Ranek Christian Oeing Rebekah Sanchez-Hodge Kristen M. Kokkonen-Simon Danielle Dillard M. Imran Aslam Peter P. Rainer Sumita Mishra Brittany Dunkerly-Eyring Ronald J. Holewinski Cornelia Virus Huaqun Zhang Matthew M. Mannion Vineet Agrawal Virginia Hahn Dong I. Lee Masayuki Sasaki Jennifer E. Van Eyk Monte S. Willis Richard C. Page Jonathan C. Schisler David A. Kass
author_sort	Mark J. Ranek
title	CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury
title_short	CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury
title_full	CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury
title_fullStr	CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury
title_full_unstemmed	CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury
title_sort	chip phosphorylation by protein kinase g enhances protein quality control and attenuates cardiac ischemic injury
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-10-01
description	Carboxyl terminus of Hsc70-interacting protein (CHIP) is proteostasis regulator. Here the authors show that CHIP-mediated protein turnover is enhanced by PKG-mediated phosphorylation, which results in attenuated cardiac ischemic proteotoxicity.
url	https://doi.org/10.1038/s41467-020-18980-x
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CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury

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