New Insights into the Role of Autophagy in Tumor Immune Microenvironment
The tumor microenvironment is a complex system that is affected by various factors, including hypoxia, acidosis, and immune and inflammatory responses, which have significant effects on tumor adhesion, invasion, metastasis, angiogenesis, and autophagy. In this hostile tumor microenvironment, autopha...
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doaj-7e73801cc62c4d94a486dde1cf418fd72020-11-25T02:29:16ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-07-01187156610.3390/ijms18071566ijms18071566New Insights into the Role of Autophagy in Tumor Immune MicroenvironmentChia-Jung Li0Wan-Ting Liao1Meng-Yu Wu2Pei-Yi Chu3Research Assistant Center, Show Chwan Memorial Hospital, Changhua 500, TaiwanChinese Medicine Department, Show Chwan Memorial Hospital, Changhua 500, TaiwanDepartment of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanDepartment of Pathology, Show Chwan Memorial Hospital, Changhua 500, TaiwanThe tumor microenvironment is a complex system that is affected by various factors, including hypoxia, acidosis, and immune and inflammatory responses, which have significant effects on tumor adhesion, invasion, metastasis, angiogenesis, and autophagy. In this hostile tumor microenvironment, autophagy of tumor cells can promote tumor growth and metastasis. As autophagy is a double-edged sword in tumors, treatment of cancer via regulation of autophagy is extremely complicated. Therefore, understanding the relationship between tumor autophagy and the tumor microenvironment is extremely important. As the immune milieu plays an important role in tumor development, immunotherapy has become a promising form of cancer therapy. A multi-pronged treatment approach using immunotherapy and molecular targets may become the major direction for future cancer treatments. This article reviews existing knowledge regarding the immune factors in the tumor microenvironment and the status of tumor autophagy research.https://www.mdpi.com/1422-0067/18/7/1566autophagytumor immunitytumor microenvironmenttumor immunotherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chia-Jung Li Wan-Ting Liao Meng-Yu Wu Pei-Yi Chu |
spellingShingle |
Chia-Jung Li Wan-Ting Liao Meng-Yu Wu Pei-Yi Chu New Insights into the Role of Autophagy in Tumor Immune Microenvironment International Journal of Molecular Sciences autophagy tumor immunity tumor microenvironment tumor immunotherapy |
author_facet |
Chia-Jung Li Wan-Ting Liao Meng-Yu Wu Pei-Yi Chu |
author_sort |
Chia-Jung Li |
title |
New Insights into the Role of Autophagy in Tumor Immune Microenvironment |
title_short |
New Insights into the Role of Autophagy in Tumor Immune Microenvironment |
title_full |
New Insights into the Role of Autophagy in Tumor Immune Microenvironment |
title_fullStr |
New Insights into the Role of Autophagy in Tumor Immune Microenvironment |
title_full_unstemmed |
New Insights into the Role of Autophagy in Tumor Immune Microenvironment |
title_sort |
new insights into the role of autophagy in tumor immune microenvironment |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2017-07-01 |
description |
The tumor microenvironment is a complex system that is affected by various factors, including hypoxia, acidosis, and immune and inflammatory responses, which have significant effects on tumor adhesion, invasion, metastasis, angiogenesis, and autophagy. In this hostile tumor microenvironment, autophagy of tumor cells can promote tumor growth and metastasis. As autophagy is a double-edged sword in tumors, treatment of cancer via regulation of autophagy is extremely complicated. Therefore, understanding the relationship between tumor autophagy and the tumor microenvironment is extremely important. As the immune milieu plays an important role in tumor development, immunotherapy has become a promising form of cancer therapy. A multi-pronged treatment approach using immunotherapy and molecular targets may become the major direction for future cancer treatments. This article reviews existing knowledge regarding the immune factors in the tumor microenvironment and the status of tumor autophagy research. |
topic |
autophagy tumor immunity tumor microenvironment tumor immunotherapy |
url |
https://www.mdpi.com/1422-0067/18/7/1566 |
work_keys_str_mv |
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