Distribution of lymphadenopathy in patients with Kikuchi disease
Background: Cervical lymphadenopathy is among the cardinal manifestations of Kikuchi disease (KD). The incidences and locations of extra-cervical lymph nodes (LNs) involvement in KD have not been comprehensively reported. Methods: From 2003 to 2016, 60 patients with pathologically confirmed KD and w...
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Format: | Article |
Language: | English |
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Elsevier
2021-04-01
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Series: | Journal of Microbiology, Immunology and Infection |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118219301525 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lung-Chiung Chen Chao-Jan Wang Yu-Chuan Chang Shian-Sen Shie Tzou-Yien Lin Yu-Chia Hsieh Kuan-Ying Arthur Huang Chen-Yen Kuo Cheng-Hsun Chiu Yhu-Chering Huang Chih-Jung Chen |
spellingShingle |
Lung-Chiung Chen Chao-Jan Wang Yu-Chuan Chang Shian-Sen Shie Tzou-Yien Lin Yu-Chia Hsieh Kuan-Ying Arthur Huang Chen-Yen Kuo Cheng-Hsun Chiu Yhu-Chering Huang Chih-Jung Chen Distribution of lymphadenopathy in patients with Kikuchi disease Journal of Microbiology, Immunology and Infection Kikuchi disease Lymphadenopathy Nuclear medicine Computed tomography Taiwan |
author_facet |
Lung-Chiung Chen Chao-Jan Wang Yu-Chuan Chang Shian-Sen Shie Tzou-Yien Lin Yu-Chia Hsieh Kuan-Ying Arthur Huang Chen-Yen Kuo Cheng-Hsun Chiu Yhu-Chering Huang Chih-Jung Chen |
author_sort |
Lung-Chiung Chen |
title |
Distribution of lymphadenopathy in patients with Kikuchi disease |
title_short |
Distribution of lymphadenopathy in patients with Kikuchi disease |
title_full |
Distribution of lymphadenopathy in patients with Kikuchi disease |
title_fullStr |
Distribution of lymphadenopathy in patients with Kikuchi disease |
title_full_unstemmed |
Distribution of lymphadenopathy in patients with Kikuchi disease |
title_sort |
distribution of lymphadenopathy in patients with kikuchi disease |
publisher |
Elsevier |
series |
Journal of Microbiology, Immunology and Infection |
issn |
1684-1182 |
publishDate |
2021-04-01 |
description |
Background: Cervical lymphadenopathy is among the cardinal manifestations of Kikuchi disease (KD). The incidences and locations of extra-cervical lymph nodes (LNs) involvement in KD have not been comprehensively reported. Methods: From 2003 to 2016, 60 patients with pathologically confirmed KD and with computed tomography and/or whole-body inflammation scans at diagnosis were retrospectively identified. The locations, sizes and characteristics of all affected LNs were analyzed by extensive review of the image studies. The clinical and laboratory parameters were abstracted from medical records and the associations with extra-cervical LNs involvement were identified. Results: Female accounted for 35 (58.3%) patients and the median age of all patients was 21.3 years (ranges, 3–64 years). Of 59 patients with evaluable neck images, 42 (71.2%) and 16 (27.1%) patients presented with unilateral and bilateral nodal involvement, respectively, with the most common locations at level II, III and IV by Som's classification. The largest LNs appeared most commonly in level II. The incidences of extra-cervical lymphadenopathy in abdomen, pelvis, inguina, axilla and mediastinum with available images were respectively 52.9% (9/17), 47.1% (8/17), 41.2% (7/17), 30.6% (11/36) and 14.3% (8/56). When compared to cases with solitary cervical lymphadenopathy, the cases with extra-cervical lymphadenopathy had significantly greater incidences of bilateral cervical lymphadenopathy (P = .0379) and leukopenia (P = .0173). Conclusion: Unilateral cervical lymphadenopathy was the most frequent form of LNs involvement of KD. Extra-cervical lymphadenopathy was not uncommon and was associated with the appearance of bilateral distribution of cervical LNs and leukopenia. |
topic |
Kikuchi disease Lymphadenopathy Nuclear medicine Computed tomography Taiwan |
url |
http://www.sciencedirect.com/science/article/pii/S1684118219301525 |
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doaj-7e7454591cd848d3b2667a644bf34cdb2021-04-24T05:56:33ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822021-04-01542299304Distribution of lymphadenopathy in patients with Kikuchi diseaseLung-Chiung Chen0Chao-Jan Wang1Yu-Chuan Chang2Shian-Sen Shie3Tzou-Yien Lin4Yu-Chia Hsieh5Kuan-Ying Arthur Huang6Chen-Yen Kuo7Cheng-Hsun Chiu8Yhu-Chering Huang9Chih-Jung Chen10Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan; Department of Pediatrics, Taoyuan Armed Forces General Hospital, 325 Taoyuan, TaiwanDepartment of Radiology, Chang Gung Memorial Hospital, 333 Taoyuan, TaiwanDepartment of Nuclear Medicine, Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan; Department of Medical Imaging and Radiological Sciences, Chang Gung University, 333 Taoyuan, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan; School of Medicine, College of Medicine, Chang Gung University, 333 Taoyuan, TaiwanDivision of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan; School of Medicine, College of Medicine, Chang Gung University, 333 Taoyuan, TaiwanDivision of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan; School of Medicine, College of Medicine, Chang Gung University, 333 Taoyuan, TaiwanDivision of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan; School of Medicine, College of Medicine, Chang Gung University, 333 Taoyuan, TaiwanDivision of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan; School of Medicine, College of Medicine, Chang Gung University, 333 Taoyuan, TaiwanDivision of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan; School of Medicine, College of Medicine, Chang Gung University, 333 Taoyuan, TaiwanDivision of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan; School of Medicine, College of Medicine, Chang Gung University, 333 Taoyuan, TaiwanDivision of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan; School of Medicine, College of Medicine, Chang Gung University, 333 Taoyuan, Taiwan; Corresponding author. Division of Pediatric Infectious Diseases, Department of Paediatrics, Chang Gung Memorial Hospital, Linkou, No. 5, Fu-Shin Street, Kweishan, 333, Taoyuan, Taiwan. Fax: +886 3 3971827.Background: Cervical lymphadenopathy is among the cardinal manifestations of Kikuchi disease (KD). The incidences and locations of extra-cervical lymph nodes (LNs) involvement in KD have not been comprehensively reported. Methods: From 2003 to 2016, 60 patients with pathologically confirmed KD and with computed tomography and/or whole-body inflammation scans at diagnosis were retrospectively identified. The locations, sizes and characteristics of all affected LNs were analyzed by extensive review of the image studies. The clinical and laboratory parameters were abstracted from medical records and the associations with extra-cervical LNs involvement were identified. Results: Female accounted for 35 (58.3%) patients and the median age of all patients was 21.3 years (ranges, 3–64 years). Of 59 patients with evaluable neck images, 42 (71.2%) and 16 (27.1%) patients presented with unilateral and bilateral nodal involvement, respectively, with the most common locations at level II, III and IV by Som's classification. The largest LNs appeared most commonly in level II. The incidences of extra-cervical lymphadenopathy in abdomen, pelvis, inguina, axilla and mediastinum with available images were respectively 52.9% (9/17), 47.1% (8/17), 41.2% (7/17), 30.6% (11/36) and 14.3% (8/56). When compared to cases with solitary cervical lymphadenopathy, the cases with extra-cervical lymphadenopathy had significantly greater incidences of bilateral cervical lymphadenopathy (P = .0379) and leukopenia (P = .0173). Conclusion: Unilateral cervical lymphadenopathy was the most frequent form of LNs involvement of KD. Extra-cervical lymphadenopathy was not uncommon and was associated with the appearance of bilateral distribution of cervical LNs and leukopenia.http://www.sciencedirect.com/science/article/pii/S1684118219301525Kikuchi diseaseLymphadenopathyNuclear medicineComputed tomographyTaiwan |