Possibility of selection against mtDNA mutations in tumors

<p>Abstract</p> <p>Several studies of tumors have revealed substantial numbers of clonally expanded somatic mutations in mitochondrial DNA (mtDNA), not observed in adjacent intact tissues. These findings were interpreted as indicating the involvement of mtDNA mutations in tumorigen...

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Main Authors:	Reis RJ Shmookler, Khaidakov M
Format:	Article
Language:	English
Published:	BMC 2005-09-01
Series:	Molecular Cancer
Subjects:	tumorigenesis mitochondrial DNA mutations
Online Access:	http://www.molecular-cancer.com/content/4/1/36

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spelling	doaj-7e7e98ce9113477688d7c45aa8d513342020-11-24T20:55:59ZengBMCMolecular Cancer1476-45982005-09-01413610.1186/1476-4598-4-36Possibility of selection against mtDNA mutations in tumorsReis RJ ShmooklerKhaidakov M<p>Abstract</p> <p>Several studies of tumors have revealed substantial numbers of clonally expanded somatic mutations in mitochondrial DNA (mtDNA), not observed in adjacent intact tissues. These findings were interpreted as indicating the involvement of mtDNA mutations in tumorigenesis. Such comparisons, however, ignore an important confounding factor: the monoclonal origin of tumors as opposed to the highly polyclonal nature of normal tissues. Analysis of recently published data on the incidence of somatic mutations in nontumor monoclonal cells suggests that, contrary to the prevailing view, the process of tumorigenesis may be accompanied by active selection against detrimental mtDNA mutations.</p> http://www.molecular-cancer.com/content/4/1/36tumorigenesismitochondrial DNAmutations
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Reis RJ Shmookler Khaidakov M
spellingShingle	Reis RJ Shmookler Khaidakov M Possibility of selection against mtDNA mutations in tumors Molecular Cancer tumorigenesis mitochondrial DNA mutations
author_facet	Reis RJ Shmookler Khaidakov M
author_sort	Reis RJ Shmookler
title	Possibility of selection against mtDNA mutations in tumors
title_short	Possibility of selection against mtDNA mutations in tumors
title_full	Possibility of selection against mtDNA mutations in tumors
title_fullStr	Possibility of selection against mtDNA mutations in tumors
title_full_unstemmed	Possibility of selection against mtDNA mutations in tumors
title_sort	possibility of selection against mtdna mutations in tumors
publisher	BMC
series	Molecular Cancer
issn	1476-4598
publishDate	2005-09-01
description	<p>Abstract</p> <p>Several studies of tumors have revealed substantial numbers of clonally expanded somatic mutations in mitochondrial DNA (mtDNA), not observed in adjacent intact tissues. These findings were interpreted as indicating the involvement of mtDNA mutations in tumorigenesis. Such comparisons, however, ignore an important confounding factor: the monoclonal origin of tumors as opposed to the highly polyclonal nature of normal tissues. Analysis of recently published data on the incidence of somatic mutations in nontumor monoclonal cells suggests that, contrary to the prevailing view, the process of tumorigenesis may be accompanied by active selection against detrimental mtDNA mutations.</p>
topic	tumorigenesis mitochondrial DNA mutations
url	http://www.molecular-cancer.com/content/4/1/36
work_keys_str_mv	AT reisrjshmookler possibilityofselectionagainstmtdnamutationsintumors AT khaidakovm possibilityofselectionagainstmtdnamutationsintumors
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Possibility of selection against mtDNA mutations in tumors

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