Treatment experience of intractable headache in patients with growth hormone ⁃ secreting pituitary adenoma
Background Headache is a common complaint in growth hormone (GH) ⁃ secreting pituitary adenoma and considered to be relieved after tumor removed. However, some headache could be resistant after surgery, which is rare and intractable. This article summarized the clinical characteristics and diagnosis...
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Tianjin Huanhu Hospital
2020-03-01
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doaj-7e82e39c1ada4f65835ef92f9365a7052020-11-25T03:05:54ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312020-03-012031911972057Treatment experience of intractable headache in patients with growth hormone ⁃ secreting pituitary adenomaYi⁃ding FENGKan DENGRen⁃zhi WANGBackground Headache is a common complaint in growth hormone (GH) ⁃ secreting pituitary adenoma and considered to be relieved after tumor removed. However, some headache could be resistant after surgery, which is rare and intractable. This article summarized the clinical characteristics and diagnosis and treatment of intractable headache combined with GH ⁃ secreting pituitary adenoma. Methods and Results Four intractable headache combined with GH ⁃ secreting pituitary adenoma patients hospitalized in Peking Union Medical College Hospital from Febuary 2014 to July 2017 were reviewed. All the 4 patients received transsphenoidal surgery again and took long ⁃ acting somatostatin analogs (SSTAs) to control headache symptoms after admission. The serum GH, insulin ⁃ like growth factor ⁃ 1 (IGF ⁃ 1) and GH in Oral Glucose Tolerance Test (OGTT) before surgery were (5.80 ± 2.86) , (644 ± 249) and (3.12 ± 1.37) μg/L, (3.50 ± 2.91), (362.25 ± 160.11) and (3.28 ± 2.99) μg/L in 7 days after surgery, and (3.10 ± 2.14), (357 ± 165) and (1.54 ± 1.24) μg/L 3 months after surgery. Numeric Rating Scale(NRS) was (7.50 ± 0.58), (1.75 ± 0.50) and (3.75 ± 1.50) score in different timepoints. Conclusions Long ⁃ acting SSTAs can be effective to intractable headache combined with GH⁃secreting pituitary adenoma, further studies are needed. DOI:10.3969/j.issn.1672⁃6731.2020.03.010http://www.cjcnn.org/index.php/cjcnn/article/view/2102pituitary neoplasmsgrowth hormone ⁃ secreting pituitary adenomaacromegalyheadachesomatostatin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yi⁃ding FENG Kan DENG Ren⁃zhi WANG |
spellingShingle |
Yi⁃ding FENG Kan DENG Ren⁃zhi WANG Treatment experience of intractable headache in patients with growth hormone ⁃ secreting pituitary adenoma Chinese Journal of Contemporary Neurology and Neurosurgery pituitary neoplasms growth hormone ⁃ secreting pituitary adenoma acromegaly headache somatostatin |
author_facet |
Yi⁃ding FENG Kan DENG Ren⁃zhi WANG |
author_sort |
Yi⁃ding FENG |
title |
Treatment experience of intractable headache in patients with growth hormone ⁃ secreting pituitary adenoma |
title_short |
Treatment experience of intractable headache in patients with growth hormone ⁃ secreting pituitary adenoma |
title_full |
Treatment experience of intractable headache in patients with growth hormone ⁃ secreting pituitary adenoma |
title_fullStr |
Treatment experience of intractable headache in patients with growth hormone ⁃ secreting pituitary adenoma |
title_full_unstemmed |
Treatment experience of intractable headache in patients with growth hormone ⁃ secreting pituitary adenoma |
title_sort |
treatment experience of intractable headache in patients with growth hormone ⁃ secreting pituitary adenoma |
publisher |
Tianjin Huanhu Hospital |
series |
Chinese Journal of Contemporary Neurology and Neurosurgery |
issn |
1672-6731 |
publishDate |
2020-03-01 |
description |
Background Headache is a common complaint in growth hormone (GH) ⁃ secreting pituitary adenoma and considered to be relieved after tumor removed. However, some headache could be resistant after surgery, which is rare and intractable. This article summarized the clinical characteristics and diagnosis and treatment of intractable headache combined with GH ⁃ secreting pituitary adenoma. Methods and Results Four intractable headache combined with GH ⁃ secreting pituitary adenoma patients hospitalized in Peking Union Medical College Hospital from Febuary 2014 to July 2017 were reviewed. All the 4 patients received transsphenoidal surgery again and took long ⁃ acting somatostatin analogs (SSTAs) to control headache symptoms after admission. The serum GH, insulin ⁃ like growth factor ⁃ 1 (IGF ⁃ 1) and GH in Oral Glucose Tolerance Test (OGTT) before surgery were (5.80 ± 2.86) , (644 ± 249) and (3.12 ± 1.37) μg/L, (3.50 ± 2.91), (362.25 ± 160.11) and (3.28 ± 2.99) μg/L in 7 days after surgery, and (3.10 ± 2.14), (357 ± 165) and (1.54 ± 1.24) μg/L 3 months after surgery. Numeric Rating Scale(NRS) was (7.50 ± 0.58), (1.75 ± 0.50) and (3.75 ± 1.50) score in different timepoints. Conclusions Long ⁃ acting SSTAs can be effective to intractable headache combined with GH⁃secreting pituitary adenoma, further studies are needed.
DOI:10.3969/j.issn.1672⁃6731.2020.03.010 |
topic |
pituitary neoplasms growth hormone ⁃ secreting pituitary adenoma acromegaly headache somatostatin |
url |
http://www.cjcnn.org/index.php/cjcnn/article/view/2102 |
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