Fuchs endothelial corneal dystrophy: current perspectives
Gustavo Vedana, Guadalupe Villarreal Jr, Albert S Jun Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA Abstract: Fuchs endothelial corneal dystrophy (FECD) is the most common corneal dystrophy and frequently results in vision loss. Hallmarks of the disease incl...
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doaj-7e92013fd46e432992676b35f0f7a83d2020-11-25T01:30:59ZengDove Medical PressClinical Ophthalmology1177-54832016-02-012016Issue 132133025620Fuchs endothelial corneal dystrophy: current perspectivesVedana GVillarreal Jr GJun ASGustavo Vedana, Guadalupe Villarreal Jr, Albert S Jun Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA Abstract: Fuchs endothelial corneal dystrophy (FECD) is the most common corneal dystrophy and frequently results in vision loss. Hallmarks of the disease include loss of corneal endothelial cells and formation of excrescences of Descemet’s membrane. Later stages involve all layers of the cornea. Impairment of endothelial barrier and pump function and cell death from oxidative and unfolded protein stress contribute to disease progression. The genetic basis of FECD includes numerous genes and chromosomal loci, although alterations in the transcription factor 4 gene are associated with the majority of cases. Definitive treatment of FECD is corneal transplantation. In this paper, we highlight advances that have been made in understanding FECD’s clinical features, pathophysiology, and genetics. We also discuss recent advances in endothelial keratoplasty and potential future treatments. Keywords: Fuchs endothelial corneal dystrophy, corneal endothelial cell, corneal transplantation, Descemet’s stripping automated endothelial keratoplasty, Descemet’s membrane endothelial keratoplasty, endothelial keratoplastyhttps://www.dovepress.com/fuchs-endothelial-corneal-dystrophy-current-perspectives-peer-reviewed-article-OPTHFuchs endothelial corneal dystrophy (FECD)corneal endothelial cellcorneal transplantationDescemet stripping automated endothelial keratoplasty (DSAEK)Descemet membrane endothelial keratoplasty (DMEK)endothelial keratoplasty. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vedana G Villarreal Jr G Jun AS |
spellingShingle |
Vedana G Villarreal Jr G Jun AS Fuchs endothelial corneal dystrophy: current perspectives Clinical Ophthalmology Fuchs endothelial corneal dystrophy (FECD) corneal endothelial cell corneal transplantation Descemet stripping automated endothelial keratoplasty (DSAEK) Descemet membrane endothelial keratoplasty (DMEK) endothelial keratoplasty. |
author_facet |
Vedana G Villarreal Jr G Jun AS |
author_sort |
Vedana G |
title |
Fuchs endothelial corneal dystrophy: current perspectives |
title_short |
Fuchs endothelial corneal dystrophy: current perspectives |
title_full |
Fuchs endothelial corneal dystrophy: current perspectives |
title_fullStr |
Fuchs endothelial corneal dystrophy: current perspectives |
title_full_unstemmed |
Fuchs endothelial corneal dystrophy: current perspectives |
title_sort |
fuchs endothelial corneal dystrophy: current perspectives |
publisher |
Dove Medical Press |
series |
Clinical Ophthalmology |
issn |
1177-5483 |
publishDate |
2016-02-01 |
description |
Gustavo Vedana, Guadalupe Villarreal Jr, Albert S Jun Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA Abstract: Fuchs endothelial corneal dystrophy (FECD) is the most common corneal dystrophy and frequently results in vision loss. Hallmarks of the disease include loss of corneal endothelial cells and formation of excrescences of Descemet’s membrane. Later stages involve all layers of the cornea. Impairment of endothelial barrier and pump function and cell death from oxidative and unfolded protein stress contribute to disease progression. The genetic basis of FECD includes numerous genes and chromosomal loci, although alterations in the transcription factor 4 gene are associated with the majority of cases. Definitive treatment of FECD is corneal transplantation. In this paper, we highlight advances that have been made in understanding FECD’s clinical features, pathophysiology, and genetics. We also discuss recent advances in endothelial keratoplasty and potential future treatments. Keywords: Fuchs endothelial corneal dystrophy, corneal endothelial cell, corneal transplantation, Descemet’s stripping automated endothelial keratoplasty, Descemet’s membrane endothelial keratoplasty, endothelial keratoplasty |
topic |
Fuchs endothelial corneal dystrophy (FECD) corneal endothelial cell corneal transplantation Descemet stripping automated endothelial keratoplasty (DSAEK) Descemet membrane endothelial keratoplasty (DMEK) endothelial keratoplasty. |
url |
https://www.dovepress.com/fuchs-endothelial-corneal-dystrophy-current-perspectives-peer-reviewed-article-OPTH |
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