Bone Morphogenetic Proteins and Diabetic Retinopathy
Bone morphogenetic proteins (BMPs) play an important role in bone formation and repair. Recent studies underscored their essential role in the normal development of several organs and vascular homeostasis in health and diseases. Elevated levels of BMPs have been linked to the development of cardiova...
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doaj-7e9270f7a00d4dbdad6271d52e62323a2021-04-18T23:00:51ZengMDPI AGBiomolecules2218-273X2021-04-011159359310.3390/biom11040593Bone Morphogenetic Proteins and Diabetic RetinopathyKhaled Elmasry0Samar Habib1Mohamed Moustafa2Mohamed Al-Shabrawey3Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USADepartment of Medical Parasitology, Mansoura Faculty of Medicine, Mansoura University, Dakahlia Governorate 35516, EgyptCulver Vision discovery Institute, Augusta University, Augusta, GA 30912, USADepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USABone morphogenetic proteins (BMPs) play an important role in bone formation and repair. Recent studies underscored their essential role in the normal development of several organs and vascular homeostasis in health and diseases. Elevated levels of BMPs have been linked to the development of cardiovascular complications of diabetes mellitus. However, their particular role in the pathogenesis of microvascular dysfunction associated with diabetic retinopathy (DR) is still under-investigated. Accumulated evidence from our and others’ studies suggests the involvement of BMP signaling in retinal inflammation, hyperpermeability and pathological neovascularization in DR and age-related macular degeneration (AMD). Therefore, targeting BMP signaling in diabetes is proposed as a potential therapeutic strategy to halt the development of microvascular dysfunction in retinal diseases, particularly in DR. The goal of this review article is to discuss the biological functions of BMPs, their underlying mechanisms and their potential role in the pathogenesis of DR in particular.https://www.mdpi.com/2218-273X/11/4/593bone morphognetic proteinsBMP2BMP4diabetic retinopathyage-related macular degeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Khaled Elmasry Samar Habib Mohamed Moustafa Mohamed Al-Shabrawey |
spellingShingle |
Khaled Elmasry Samar Habib Mohamed Moustafa Mohamed Al-Shabrawey Bone Morphogenetic Proteins and Diabetic Retinopathy Biomolecules bone morphognetic proteins BMP2 BMP4 diabetic retinopathy age-related macular degeneration |
author_facet |
Khaled Elmasry Samar Habib Mohamed Moustafa Mohamed Al-Shabrawey |
author_sort |
Khaled Elmasry |
title |
Bone Morphogenetic Proteins and Diabetic Retinopathy |
title_short |
Bone Morphogenetic Proteins and Diabetic Retinopathy |
title_full |
Bone Morphogenetic Proteins and Diabetic Retinopathy |
title_fullStr |
Bone Morphogenetic Proteins and Diabetic Retinopathy |
title_full_unstemmed |
Bone Morphogenetic Proteins and Diabetic Retinopathy |
title_sort |
bone morphogenetic proteins and diabetic retinopathy |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2021-04-01 |
description |
Bone morphogenetic proteins (BMPs) play an important role in bone formation and repair. Recent studies underscored their essential role in the normal development of several organs and vascular homeostasis in health and diseases. Elevated levels of BMPs have been linked to the development of cardiovascular complications of diabetes mellitus. However, their particular role in the pathogenesis of microvascular dysfunction associated with diabetic retinopathy (DR) is still under-investigated. Accumulated evidence from our and others’ studies suggests the involvement of BMP signaling in retinal inflammation, hyperpermeability and pathological neovascularization in DR and age-related macular degeneration (AMD). Therefore, targeting BMP signaling in diabetes is proposed as a potential therapeutic strategy to halt the development of microvascular dysfunction in retinal diseases, particularly in DR. The goal of this review article is to discuss the biological functions of BMPs, their underlying mechanisms and their potential role in the pathogenesis of DR in particular. |
topic |
bone morphognetic proteins BMP2 BMP4 diabetic retinopathy age-related macular degeneration |
url |
https://www.mdpi.com/2218-273X/11/4/593 |
work_keys_str_mv |
AT khaledelmasry bonemorphogeneticproteinsanddiabeticretinopathy AT samarhabib bonemorphogeneticproteinsanddiabeticretinopathy AT mohamedmoustafa bonemorphogeneticproteinsanddiabeticretinopathy AT mohamedalshabrawey bonemorphogeneticproteinsanddiabeticretinopathy |
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