Cognitive impairment and electroconvulsive therapy in geriatric depression, what could be the role of rivastigmine? A case series
Electroconvulsive therapy (ECT), albeit highly effective in treating depression, is frequently associated with cognitive impairment, either temporary or more persistent. Especially in older patients, who generally respond even better, serious cognitive impairment during the course of ECT may lead to...
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2015-09-01
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doaj-7e97fdd5498949fe923c5ca2700552912021-03-02T09:10:51ZengMDPI AGClinics and Practice2039-72752039-72832015-09-015310.4081/cp.2015.780315Cognitive impairment and electroconvulsive therapy in geriatric depression, what could be the role of rivastigmine? A case seriesAudrey Monica van Schaik0Didi Rhebergen1Marieke Jantien Henstra2Daniel J. Kadouch3Eric van Exel4Maximilianus Lourentius Stek5GGZ inGeest, AmsterdamGGZ inGeest, Amsterdam; Department of Psychiatry and the EMGO Institute for Health and Care Research, VU University Medical Center, AmsterdamDepartment of Internal Medicine, Section of Geriatric Medicine, VU University Medical Center, AmsterdamAcademic Medical Center, University of Amsterdam, AmsterdamDepartment of Psychiatry and the EMGO Institute for Health and Care Research, VU University Medical Center, AmsterdamDepartment of Psychiatry and the EMGO Institute for Health and Care Research, VU University Medical Center, AmsterdamElectroconvulsive therapy (ECT), albeit highly effective in treating depression, is frequently associated with cognitive impairment, either temporary or more persistent. Especially in older patients, who generally respond even better, serious cognitive impairment during the course of ECT may lead to premature termination of ECT. Treatment of this cognitive impairment is of utmost importance. In this case series report, we present the effect of rivastigmine, an acetylcholinesterase inhibitor, on cognitive impairment in three older, severely depressed patients during or after a course of ECT. An improvement of cognitive functioning, in particular a decline of confusional symptoms, was observed in two patients with structural brain alterations associated with aging. In the other patient, who suffered primarily from amnesia, no effect of rivastigmine was observed. These preliminary results emphasize the need for detailed profiling of cognitive impairment when developing a research design to study the potential benefits of rivastigmine in the prevention or treatment of cognitive impairment in severely depressed patients treated with ECT.https://www.clinicsandpractice.org/index.php/cp/article/view/780Depressioncognitive impairmentelectroconvulsive therapyelderlyacetylcholinesterase inhibitorrivastigmine. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Audrey Monica van Schaik Didi Rhebergen Marieke Jantien Henstra Daniel J. Kadouch Eric van Exel Maximilianus Lourentius Stek |
spellingShingle |
Audrey Monica van Schaik Didi Rhebergen Marieke Jantien Henstra Daniel J. Kadouch Eric van Exel Maximilianus Lourentius Stek Cognitive impairment and electroconvulsive therapy in geriatric depression, what could be the role of rivastigmine? A case series Clinics and Practice Depression cognitive impairment electroconvulsive therapy elderly acetylcholinesterase inhibitor rivastigmine. |
author_facet |
Audrey Monica van Schaik Didi Rhebergen Marieke Jantien Henstra Daniel J. Kadouch Eric van Exel Maximilianus Lourentius Stek |
author_sort |
Audrey Monica van Schaik |
title |
Cognitive impairment and electroconvulsive therapy in geriatric depression, what could be the role of rivastigmine? A case series |
title_short |
Cognitive impairment and electroconvulsive therapy in geriatric depression, what could be the role of rivastigmine? A case series |
title_full |
Cognitive impairment and electroconvulsive therapy in geriatric depression, what could be the role of rivastigmine? A case series |
title_fullStr |
Cognitive impairment and electroconvulsive therapy in geriatric depression, what could be the role of rivastigmine? A case series |
title_full_unstemmed |
Cognitive impairment and electroconvulsive therapy in geriatric depression, what could be the role of rivastigmine? A case series |
title_sort |
cognitive impairment and electroconvulsive therapy in geriatric depression, what could be the role of rivastigmine? a case series |
publisher |
MDPI AG |
series |
Clinics and Practice |
issn |
2039-7275 2039-7283 |
publishDate |
2015-09-01 |
description |
Electroconvulsive therapy (ECT), albeit highly effective in treating depression, is frequently associated with cognitive impairment, either temporary or more persistent. Especially in older patients, who generally respond even better, serious cognitive impairment during the course of ECT may lead to premature termination of ECT. Treatment of this cognitive impairment is of utmost importance. In this case series report, we present the effect of rivastigmine, an acetylcholinesterase inhibitor, on cognitive impairment in three older, severely depressed patients during or after a course of ECT. An improvement of cognitive functioning, in particular a decline of confusional symptoms, was observed in two patients with structural brain alterations associated with aging. In the other patient, who suffered primarily from amnesia, no effect of rivastigmine was observed. These preliminary results emphasize the need for detailed profiling of cognitive impairment when developing a research design to study the potential benefits of rivastigmine in the prevention or treatment of cognitive impairment in severely depressed patients treated with ECT. |
topic |
Depression cognitive impairment electroconvulsive therapy elderly acetylcholinesterase inhibitor rivastigmine. |
url |
https://www.clinicsandpractice.org/index.php/cp/article/view/780 |
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