UCH-L1 and GFAP Serum Levels in Neonates with Hypoxic-Ischemic Encephalopathy: A single center pilot study

UCH-L1 and GFAP Serum Levels in Neonates with Hypoxic-Ischemic Encephalopathy: A single center pilot study

Objective - We examined two potential biomarkers of brain damage in HIE neonates: glial fibrillary acidic protein (GFAP; a marker of gliosis) and ubiquitin C-terminal hydrolase L1 (UCH-L1; a marker of neuronal injury). We hypothesized the biomarkers would be measurable in cord blood of healthy neona...

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Bibliographic Details
Main Authors: Martha V. Douglas-Escobar, Shelley C. Heaton, Jeffrey Allan Bennett, Linda J Young, Olena eGlushakova, Xiaohui eXu, Daphna Yasova Barbeau, Candice eRossignol, Cindy eMiller, Alissa M Old Crow, Ronald L Hayes, Michael D. Weiss
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Neurology
Subjects:
Biomarkers, Pharmacological
Neonatology
Brain Injury
neurocritical care
hypoxic-ischemic injury
neonatal brain injury
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00273/full

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