IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19
Abstract Background COVID-19 is a viral respiratory disease caused by the severe acute respiratory syndrome-Coronavirus type 2 (SARS-CoV-2). Patients with this disease may be more prone to venous or arterial thrombosis because of the activation of many factors involved in it, including inflammation,...
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doaj-7ea3562a4c7b4cf2bee002d42f241bc42020-11-25T03:44:05ZengBMCMolecular Medicine1076-15511528-36582020-10-0126111210.1186/s10020-020-00230-xIP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19Yu Chen0Jinglan Wang1Chenxi Liu2Longxiang Su3Dong Zhang4Junping Fan5Yanli Yang6Meng Xiao7Jing Xie8Yingchun Xu9Yongzhe Li10Shuyang Zhang11Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesAbstract Background COVID-19 is a viral respiratory disease caused by the severe acute respiratory syndrome-Coronavirus type 2 (SARS-CoV-2). Patients with this disease may be more prone to venous or arterial thrombosis because of the activation of many factors involved in it, including inflammation, platelet activation and endothelial dysfunction. Interferon gamma inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein 1-alpha (MIP1α) are cytokines related to thrombosis. Therefore, this study focused on these three indicators in COVID-19, with the hope to find biomarkers that are associated with patients’ outcome. Methods This is a retrospective single-center study involving 74 severe and critically ill COVID-19 patients recruited from the ICU department of the Tongji Hospital in Wuhan, China. The patients were divided into two groups: severe patients and critically ill patients. The serum IP-10, MCP-1 and MIP1α level in both groups was detected using the enzyme-linked immunosorbent assay (ELISA) kit. The clinical symptoms, laboratory test results, and the outcome of COVID-19 patients were retrospectively analyzed. Results The serum IP-10 and MCP-1 level in critically ill patients was significantly higher than that in severe patients (P < 0.001). However, no statistical difference in MIP1α between the two groups was found. The analysis of dynamic changes showed that these indicators remarkably increased in patients with poor prognosis. Since the selected patients were severe or critically ill, no significant difference was observed between survival and death. Conclusions IP-10 and MCP-1 are biomarkers associated with the severity of COVID-19 disease and can be related to the risk of death in COVID-19 patients.http://link.springer.com/article/10.1186/s10020-020-00230-xCOVID-19IP-10MCP-1Critically ill patients |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu Chen Jinglan Wang Chenxi Liu Longxiang Su Dong Zhang Junping Fan Yanli Yang Meng Xiao Jing Xie Yingchun Xu Yongzhe Li Shuyang Zhang |
spellingShingle |
Yu Chen Jinglan Wang Chenxi Liu Longxiang Su Dong Zhang Junping Fan Yanli Yang Meng Xiao Jing Xie Yingchun Xu Yongzhe Li Shuyang Zhang IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19 Molecular Medicine COVID-19 IP-10 MCP-1 Critically ill patients |
author_facet |
Yu Chen Jinglan Wang Chenxi Liu Longxiang Su Dong Zhang Junping Fan Yanli Yang Meng Xiao Jing Xie Yingchun Xu Yongzhe Li Shuyang Zhang |
author_sort |
Yu Chen |
title |
IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19 |
title_short |
IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19 |
title_full |
IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19 |
title_fullStr |
IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19 |
title_full_unstemmed |
IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19 |
title_sort |
ip-10 and mcp-1 as biomarkers associated with disease severity of covid-19 |
publisher |
BMC |
series |
Molecular Medicine |
issn |
1076-1551 1528-3658 |
publishDate |
2020-10-01 |
description |
Abstract Background COVID-19 is a viral respiratory disease caused by the severe acute respiratory syndrome-Coronavirus type 2 (SARS-CoV-2). Patients with this disease may be more prone to venous or arterial thrombosis because of the activation of many factors involved in it, including inflammation, platelet activation and endothelial dysfunction. Interferon gamma inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein 1-alpha (MIP1α) are cytokines related to thrombosis. Therefore, this study focused on these three indicators in COVID-19, with the hope to find biomarkers that are associated with patients’ outcome. Methods This is a retrospective single-center study involving 74 severe and critically ill COVID-19 patients recruited from the ICU department of the Tongji Hospital in Wuhan, China. The patients were divided into two groups: severe patients and critically ill patients. The serum IP-10, MCP-1 and MIP1α level in both groups was detected using the enzyme-linked immunosorbent assay (ELISA) kit. The clinical symptoms, laboratory test results, and the outcome of COVID-19 patients were retrospectively analyzed. Results The serum IP-10 and MCP-1 level in critically ill patients was significantly higher than that in severe patients (P < 0.001). However, no statistical difference in MIP1α between the two groups was found. The analysis of dynamic changes showed that these indicators remarkably increased in patients with poor prognosis. Since the selected patients were severe or critically ill, no significant difference was observed between survival and death. Conclusions IP-10 and MCP-1 are biomarkers associated with the severity of COVID-19 disease and can be related to the risk of death in COVID-19 patients. |
topic |
COVID-19 IP-10 MCP-1 Critically ill patients |
url |
http://link.springer.com/article/10.1186/s10020-020-00230-x |
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