C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

<p>Abstract</p> <p>Background</p> <p>TDP-43 proteinopathies are characterized by loss of nuclear TDP-43 expression and formation of C-terminal TDP-43 fragmentation and accumulation in the cytoplasm. Recent studies have shown that TDP-43 can accumulate in RNA stress gran...

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Bibliographic Details
Main Authors: Masters Colin L, Li Qiao-Xin, Caragounis Aphrodite, Liddell Jeffrey R, Price Katherine A, Ng Dominic CH, Vella Laura J, Parker Sarah J, Meyerowitz Jodi, Nonaka Takashi, Hasegawa Masato, Bogoyevitch Marie A, Kanninen Katja M, Crouch Peter J, White Anthony R
Format: Article
Language:English
Published: BMC 2011-08-01
Series:Molecular Neurodegeneration
Subjects:
TDP-43
stress granules
JNK
kinases
oxidative stress
paraquat
hnRNP
Online Access:http://www.molecularneurodegeneration.com/content/6/1/57

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