Long-Chain Acyl-Carnitines Interfere with Mitochondrial ATP Production Leading to Cardiac Dysfunction in Zebrafish

Long-Chain Acyl-Carnitines Interfere with Mitochondrial ATP Production Leading to Cardiac Dysfunction in Zebrafish

In the human heart, the energy supplied by the production of ATP is predominately accomplished by ß-oxidation in mitochondria, using fatty acids (FAs) as the primary fuel. Long-chain acylcarnitines (LCACs) are intermediate forms of FA transport that are essential for FA delivery from the cytosol int...

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Bibliographic Details
Main Authors: Deung-Dae Park, Bernd M. Gahr, Julia Krause, Wolfgang Rottbauer, Tanja Zeller, Steffen Just
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
long-chain acylcarnitine
cardiovascular disease
mitochondria
zebrafish
Online Access:https://www.mdpi.com/1422-0067/22/16/8468

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