High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons.

High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons.

The HIV-1 protein, Tat has been implicated in AIDS pathogenesis however, the amount of circulating Tat is believed to be very low and its quantification has been difficult. We performed the quantification of Tat released from infected cells and taken up by neurons using high performance capillary el...

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Bibliographic Details
Main Authors: Satish L Deshmane, Ruma Mukerjee, Shongshan Fan, Bassel E Sawaya
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3017553?pdf=render
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spelling doaj-7ec3c9a05e8f4d30836a2b83a1758d2f2020-11-24T21:23:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0161e1614810.1371/journal.pone.0016148High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons.Satish L DeshmaneRuma MukerjeeShongshan FanBassel E SawayaThe HIV-1 protein, Tat has been implicated in AIDS pathogenesis however, the amount of circulating Tat is believed to be very low and its quantification has been difficult. We performed the quantification of Tat released from infected cells and taken up by neurons using high performance capillary electrophoresis. This is the first report to successfully measure the amount of Tat in neurons and places Tat as a key player involved in HIV-associated neurocognitive disorders.http://europepmc.org/articles/PMC3017553?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Satish L Deshmane
Ruma Mukerjee
Shongshan Fan
Bassel E Sawaya
spellingShingle Satish L Deshmane
Ruma Mukerjee
Shongshan Fan
Bassel E Sawaya
High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons.
PLoS ONE
author_facet Satish L Deshmane
Ruma Mukerjee
Shongshan Fan
Bassel E Sawaya
author_sort Satish L Deshmane
title High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons.
title_short High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons.
title_full High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons.
title_fullStr High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons.
title_full_unstemmed High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons.
title_sort high-performance capillary electrophoresis for determining hiv-1 tat protein in neurons.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2011-01-01
description The HIV-1 protein, Tat has been implicated in AIDS pathogenesis however, the amount of circulating Tat is believed to be very low and its quantification has been difficult. We performed the quantification of Tat released from infected cells and taken up by neurons using high performance capillary electrophoresis. This is the first report to successfully measure the amount of Tat in neurons and places Tat as a key player involved in HIV-associated neurocognitive disorders.
url http://europepmc.org/articles/PMC3017553?pdf=render
work_keys_str_mv AT satishldeshmane highperformancecapillaryelectrophoresisfordetermininghiv1tatproteininneurons
AT rumamukerjee highperformancecapillaryelectrophoresisfordetermininghiv1tatproteininneurons
AT shongshanfan highperformancecapillaryelectrophoresisfordetermininghiv1tatproteininneurons
AT basselesawaya highperformancecapillaryelectrophoresisfordetermininghiv1tatproteininneurons
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